Tannins: An Antinutrient with Positive Effect to Manage Diabetes

International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN. International E-Bulletin: Information/News regarding: Academics and Research

Tannins: An Antinutrient with Positive Effect to Manage Diabetes

M. Kumari
S. Jain

Author Affiliations

¹Deptt of Foods and Nutrition, College of Home Science, MPUAT, Udaipur, Rajasthan, INDIA
²

Res. J. Recent Sci., Volume 1, Issue (12), Pages 70-73, December,2 (2012)

Abstract

Plant tannins, including hydrolysable and condensed varieties, are well known antioxidants in medicinal plants, foods, and edible fruits. Phenolic compounds and flavonoids are a unique category of plant phytochemicals especially in terms of their vast potential health-benefiting properties. Tannins are potential antioxidants. They have been considered to be cardio-protective, anti-inflammatory, anti-carcinogenic and anti-mutagenic, among others. Tannins enhance glucose uptake and inhibit adipogenesis, thus being potential drugs for the treatment of NIDDM.Tannins can improve the pathological oxidativestate of a diabetic situation. Many earlier studies suggested that phenolic compounds and flavonoids protect against many types of cancer. In particular, phenolic compounds have been reported to modulate intracellular signalling through PI3K and p38 MAPK pathways, modulating the activity of target enzymes and modulating gene expression. Condensed Tannins have a wide range of biological and pharmacological activities including antioxidative, cardio-protective, antitumor, antibacterial, antiviral, anti-inflammatory and immune-modulatory. These specific phytochemicals provide a promising area of research for future human studies and potential nutraceutical for disease prevention and treatment.

References

Horvath P.J., The Nutritional and Ecological Significance of Tannins and Related Polyphenols. M.S. Thesis. Cornell University, Ithaca, New York, USA, (1981)
Porter L.J., The Flavonoids. In: Harborne JB, editor. Advances in Research since 1986. London: Chapman & Hall, 23–55 (1986)
Karchesy J. and Hemingway R.W., Condensed tannins (4-8, 2B-O-7) -linked procyanidins in Archis hypogea L, J. Agric. Food Chem. 34, 996-970 (1986)
Martin-Tanguy J., Guillaume J. and Kossa A., Condensed tannins in horse bean seeds: chemical structure and effects on poultry, J. Sci. Food Agric.,28, 757-765 (1977)
Subramanian V., Butler L.G., Jambunathan R. and Prasada Rao K.E., Some agronomic and biochemical characters of brown sorghums and their possible role in bird resistance, J. Agric. Food Chem. 31, 1303-1307 (1983)
Bennick A., Interaction of plant polyphenols with salivary proteins, Crit. Rev. Oral Biol. Med.,13, 184-196 (2002)
Arts ICW., VandePutte B. and Hollman P.C.H., Catechin contents of foods commonly consumed in the Netherlands. 1. Fruits, vegetables, staple foods, and processed food, J. Agric Food Chem.,48, 1746–51 (2000)
Shimizu M., Kobayashi Y., Suzuki M., Satsu H. and Miyamoto Y., Regulation of intestinal glucose transport by tea catechins, Biofactors, 13, 61-65 (2000)
Kao Y.H., Hiipakka R.A. and Liao S., Modulation of endocrine systems and food intake by green tea epigallocatechin gallate, Endocrinology.,141, 980-987 (2000)
Kim M.J., Ryu G.R., Chung J.S., Sim S.S., Min D.S., Rhie D.J., Yoon S.H., Hahn S.J., Kim M.S. and Jo Y.H., Protective effects of epicatechin against the toxic effects of streptozotocin on rat pancreatic islets: in vivo and in vitro, Pancreas.,26, 292-299 (2003)
Anderson R.A. and Polansky M.M., Tea enhances insulin activity J Agric Food Chem.,50, 7182-7186 (2002)
Pinent M., Blay M., Blade M.C., Salvado M.J., Arola L. and Ardevol A., Grape seedderived procyanidins have an antihyperglycemic effect in streptozotocin-induced diabetic rats and insulinomimetic activity in insulin-sensitive cell lines, Endocrinology.,145, 4985-4990 (2004)
Eloranta J.J. and Kullak-Ublick G.A., Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism, Arch Biochem Biophys.,433, 397-412 (2005)
Beaven S.W. and Tontonoz P., Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia, Annu Rev Med.,57, 313-329 (2006)
Bagchi M., Mimes M., Williams C., Balmoori J., Ye X., Stohs S. and Bagchi D., Acute and chronic stress-induced oxidative gastrointestinal injury in rats and the protective ability of a novel grape seed proanthocyanidin extract, Nutr Res., 19, 1189–1199 (1999)
Liu Y.Z., Cao Y.G., Ye J.Q., Wang W.G., Song K.J., Wang X.L., Wang C.H., Li R.T. and Deng XM., Immunomodulatory effects of proanthocyanidin A-1 derived in vitro from Rhododendron spiciferum, Fitoterapia.,81,108–114 (2009)
Preuss H.G., Wallerstedt D., Talpur N., Tutuncuoglu S.O., Echard B., Myers A., Bui M., Bagchi D., Effects of niacin-bound chromium and grape seed proanthocyanidin extract on the lipid profile of hypercholesterolemic subjects: a pilot study, J Med.,31, 227–246 (2000)
Sato M., Bagchi D., Tosaki A., and Das DK.., Grape seed proanthocyanidin reduces cardiomyocyte apoptosis by inhibiting ischemia/reperfusion-induced activation of JNK-1 and C-JUN, Free Radic Biol Med.,31, 729–737 (2001)
Uchida S., Hirai K., Hatanaka J., Hanato J., Umegaki K., and Yamada S., Antinociceptive effects of St. John's wort, Harpagophytum procumbens extract and grape seed proanthocyanidins extract in mice, Biol Pharm Bull.,31, 240–245 (2008)
Liu F., Kim J., Li Y., Liu X., Li J. and Chen X., An extract of Lagerstroemia speciosa L. has insulin-like glucose uptake-stimulatory and adipocyte differentiation-inhibitory activities in 3T3-L1 cells, J. Nutr.,131, 2242-2247 (2001)
Muthusamy V.S., Anand S., Sangeetha K.N., Sujatha S. and Lakshmi B.A.B.S, Tannins present in Cichorium intybus enhance glucose uptake and inhibit adipogenesis in 3T3-L1 adipocytes throughPTP1B inhibition, Chem.Biol. Interact.,174, 69-78 (2008)
Ahmad F., Khalid P., Khan M.M., Rastogi A.K.. and Kidwai J.R., Insulin like activity in ()-epicatechin. Acta Diabetol Lat.,26, 291-300 (1989)
Waltner-Law M.E., Wang X.L., Law B.K.., Hall R.K.., Nawano M. and Granner D.K., Epigallocatechin gallate, a constituent of green tea represses hepatic glucose production, J Biol Chem.,277, 34933–34940 (2002)
Aron P.M. and Kennedy J.A., Flavan-3-ols: Nature, occurrence and biological activity, Mol. Nutr. Food Res.,52, 79-104 (2008)
Bagchi D.B., Sen C.K., Ray S.D., Das D.K.., Bagchi M., Preuss H.G. and Vinson J.A., Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract, Mutat. Res., 523, 87-97 (2003)
Khan N., Afaq F. and Mukhtar H., Cancer chemoprevention through dietary antioxidants: progress and promise. Antioxid Redox Signal., 10, 475-510 (2007)
Higdon JV. and Frei B., Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions. Crit Rev Food Sci Nutr.,43(1), 89-143(2003)

[ref1] Horvath P.J., The Nutritional and Ecological Significance of Tannins and Related Polyphenols. M.S. Thesis. Cornell University, Ithaca, New York, USA, (1981)

[ref2] Porter L.J., The Flavonoids. In: Harborne JB, editor. Advances in Research since 1986. London: Chapman & Hall, 23–55 (1986)

[ref3] Karchesy J. and Hemingway R.W., Condensed tannins (4-8, 2B-O-7) -linked procyanidins in Archis hypogea L, J. Agric. Food Chem. 34, 996-970 (1986)

[ref4] Martin-Tanguy J., Guillaume J. and Kossa A., Condensed tannins in horse bean seeds: chemical structure and effects on poultry, J. Sci. Food Agric.,28, 757-765 (1977)

[ref5] Subramanian V., Butler L.G., Jambunathan R. and Prasada Rao K.E., Some agronomic and biochemical characters of brown sorghums and their possible role in bird resistance, J. Agric. Food Chem. 31, 1303-1307 (1983)

[ref6] Bennick A., Interaction of plant polyphenols with salivary proteins, Crit. Rev. Oral Biol. Med.,13, 184-196 (2002)

[ref7] Arts ICW., VandePutte B. and Hollman P.C.H., Catechin contents of foods commonly consumed in the Netherlands. 1. Fruits, vegetables, staple foods, and processed food, J. Agric Food Chem.,48, 1746–51 (2000)

[ref8] Shimizu M., Kobayashi Y., Suzuki M., Satsu H. and Miyamoto Y., Regulation of intestinal glucose transport by tea catechins, Biofactors, 13, 61-65 (2000)

[ref9] Kao Y.H., Hiipakka R.A. and Liao S., Modulation of endocrine systems and food intake by green tea epigallocatechin gallate, Endocrinology.,141, 980-987 (2000)

[ref10] Kim M.J., Ryu G.R., Chung J.S., Sim S.S., Min D.S., Rhie D.J., Yoon S.H., Hahn S.J., Kim M.S. and Jo Y.H., Protective effects of epicatechin against the toxic effects of streptozotocin on rat pancreatic islets: in vivo and in vitro, Pancreas.,26, 292-299 (2003)

[ref11] Anderson R.A. and Polansky M.M., Tea enhances insulin activity J Agric Food Chem.,50, 7182-7186 (2002)

[ref12] Pinent M., Blay M., Blade M.C., Salvado M.J., Arola L. and Ardevol A., Grape seedderived procyanidins have an antihyperglycemic effect in streptozotocin-induced diabetic rats and insulinomimetic activity in insulin-sensitive cell lines, Endocrinology.,145, 4985-4990 (2004)

[ref13] Eloranta J.J. and Kullak-Ublick G.A., Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism, Arch Biochem Biophys.,433, 397-412 (2005)

[ref14] Beaven S.W. and Tontonoz P., Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia, Annu Rev Med.,57, 313-329 (2006)

[ref15] Bagchi M., Mimes M., Williams C., Balmoori J., Ye X., Stohs S. and Bagchi D., Acute and chronic stress-induced oxidative gastrointestinal injury in rats and the protective ability of a novel grape seed proanthocyanidin extract, Nutr Res., 19, 1189–1199 (1999)

[ref16] Liu Y.Z., Cao Y.G., Ye J.Q., Wang W.G., Song K.J., Wang X.L., Wang C.H., Li R.T. and Deng XM., Immunomodulatory effects of proanthocyanidin A-1 derived in vitro from Rhododendron spiciferum, Fitoterapia.,81,108–114 (2009)

[ref17] Preuss H.G., Wallerstedt D., Talpur N., Tutuncuoglu S.O., Echard B., Myers A., Bui M., Bagchi D., Effects of niacin-bound chromium and grape seed proanthocyanidin extract on the lipid profile of hypercholesterolemic subjects: a pilot study, J Med.,31, 227–246 (2000)

[ref18] Sato M., Bagchi D., Tosaki A., and Das DK.., Grape seed proanthocyanidin reduces cardiomyocyte apoptosis by inhibiting ischemia/reperfusion-induced activation of JNK-1 and C-JUN, Free Radic Biol Med.,31, 729–737 (2001)

[ref19] Uchida S., Hirai K., Hatanaka J., Hanato J., Umegaki K., and Yamada S., Antinociceptive effects of St. John's wort, Harpagophytum procumbens extract and grape seed proanthocyanidins extract in mice, Biol Pharm Bull.,31, 240–245 (2008)

[ref20] Liu F., Kim J., Li Y., Liu X., Li J. and Chen X., An extract of Lagerstroemia speciosa L. has insulin-like glucose uptake-stimulatory and adipocyte differentiation-inhibitory activities in 3T3-L1 cells, J. Nutr.,131, 2242-2247 (2001)

[ref21] Muthusamy V.S., Anand S., Sangeetha K.N., Sujatha S. and Lakshmi B.A.B.S, Tannins present in Cichorium intybus enhance glucose uptake and inhibit adipogenesis in 3T3-L1 adipocytes throughPTP1B inhibition, Chem.Biol. Interact.,174, 69-78 (2008)

[ref22] Ahmad F., Khalid P., Khan M.M., Rastogi A.K.. and Kidwai J.R., Insulin like activity in ()-epicatechin. Acta Diabetol Lat.,26, 291-300 (1989)

[ref23] Waltner-Law M.E., Wang X.L., Law B.K.., Hall R.K.., Nawano M. and Granner D.K., Epigallocatechin gallate, a constituent of green tea represses hepatic glucose production, J Biol Chem.,277, 34933–34940 (2002)

[ref24] Aron P.M. and Kennedy J.A., Flavan-3-ols: Nature, occurrence and biological activity, Mol. Nutr. Food Res.,52, 79-104 (2008)

[ref25] Bagchi D.B., Sen C.K., Ray S.D., Das D.K.., Bagchi M., Preuss H.G. and Vinson J.A., Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract, Mutat. Res., 523, 87-97 (2003)

[ref26] Khan N., Afaq F. and Mukhtar H., Cancer chemoprevention through dietary antioxidants: progress and promise. Antioxid Redox Signal., 10, 475-510 (2007)

[ref27] Higdon JV. and Frei B., Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions. Crit Rev Food Sci Nutr.,43(1), 89-143(2003)