International Science Community Association Research Journal of Chemical Sciences 2231-606X 8 12 2018 12 18 Antimicrobial evaluations of propionic acid of quinazolines derivatives 24 28 EN Dan Emmanuel 1 Department of Chemistry, University of Uyo, Uyo, Akwa Ibom State, Nigeria Fatunla Kayode 2 Microbiology Department, University of Uyo, Uyo Akwa Ibom State, Nigeria Shuaibu Solomon 3 Department of Chemistry, University of Uyo, Uyo, Akwa Ibom State, Nigeria Mandloi Giriraj S. 1 Department of Applied Chemistry, UIT, Barkatullah University, Bhopal, MP, India Joshi Smita 2 Department of Chemistry, Govt. Geetanjali Girls\' P.G. (Autonomus) College, Bhopal, MP, India Sarsaiya Surendra 3 Bioresource Institute for Healthy Utilization and International Research Laboratory, Medical University, Zunyi, China Amlathe Sulbha 4 Department of Applied Chemistry, UIT, Barkatullah University, Bhopal, MP, India Katariya Deepika 1 Synthesis Organic and Medicinal Chemistry lab, Department of Chemistry, Mewar University, Gangrar, Rajasthan-312901, India Joshi Ajit 2 Synthesis Organic and Medicinal Chemistry lab, Department of Chemistry, Mewar University, Gangrar, Rajasthan-312901, India > Short Communication 2018 8 9 2018 12 18 The derivatives of Propionic Acid of Quinazoline were synthesized. It was prepped by reaction of distinct amino acids with 7-nitro-2-phenyl-4H-benzo [1,3]oxazin-4-one. Configurations of same compounds have been appraised by NMR, MASS and IR spectral analysis. Synthesized compounds were screened with against following pathogenic bacteria Staphylococcus aureus, Staphylococcus pneumoniae, Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumonia. We used 500ppm concentration in DMSO for their antibacterial activity by Kirby-Baur disk diffusion method. Copyright@ International Science Community Association