International Science Community Association International Research Journal of Biological Sciences 2278-3202 9 2 2020 05 10 Distribution of Thalassemia and Hemoglobinopathy in the koch Rajbanshi ethnic group of Jhapa, Nepal 35 38 EN Oludare Agbolade James 1 Department of Plant Science and Biotechnology, Federal University Oye Ekiti, Ekiti State, Nigeria Mary Popoola Kehinde 2 Department of Plant Science and Biotechnology, Federal University Oye Ekiti, Ekiti State, Nigeria Adebare Ganiyu Sikiru 3 Department of Agronomy, Federal University, Keshere, Gombe State, Nigeria Philip Olakunle Teju 4 Department of Applied Sciences, Osun State Polytechnic, Iree Rasheed Popoola Akinola 5 Department of Crop Protection, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria Sunday OJO Elijah 6 Department of Crop Protection, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria Ehis Imonmion Joshua 7 Department of Crop Protection, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria Perfusion Amang A. 1 Department of Biological Sciences, Faculty of Science, University of Maroua, P.O. Box 814, Maroua, Cameroon Luc Vandi V. 2 Department of Biological Sciences, Faculty of Science, University of Maroua, P.O. Box 814, Maroua, Cameroon Christophe Mezui 3 Department of Biological Sciences, Higher Teachers' Training College, University of Yaoundé I, P.O. Box 47, Yaoundé, Cameroon Gael Siwe T. 4 Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon Mesmine Kuissu T. 5 Institute of Medical Research and Study of Medicinal Plants, P.O. Box 13033 Yaoundé, Cameroon Vernyuy Tan P. 6 Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon Perfusion Amang A. 1 Department of Biological Sciences, Faculty of Science, University of Maroua, P.O. Box 814, Maroua, Cameroon Luc Vandi V. 2 Department of Biological Sciences, Faculty of Science, University of Maroua, P.O. Box 814, Maroua, Cameroon Christophe Mezui 3 Department of Biological Sciences, Higher Teachers' Training College, University of Yaoundé I, P.O. Box 47, Yaoundé, Cameroon Gael Siwe T. 4 Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon Mesmine Kuissu T. 5 Institute of Medical Research and Study of Medicinal Plants, P.O. Box 13033 Yaoundé, Cameroon Vernyuy Tan P. 6 Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon Maroua Leguemairi 1 Department of Cellular and Molecular Biology, Faculty of Natural Sciences and Life, El Oued University, El Oued 39000, El Oued, Algeria Saadia Salem 2 Department of Cellular and Molecular Biology, Faculty of Natural Sciences and Life, El Oued University, El Oued 39000, El Oued, Algeria Samir Derouiche 3 Department of Cellular and Molecular Biology, Faculty of Natural Sciences and Life, El Oued University, El Oued 39000, El Oued, Algeria Nweke Christian O. 1 Department of Microbiology, Federal University of Technology Owerri, P.M.B 1526 Owerri, Nigeria Nwachukwu Ikenna N. 2 Department of Microbiology, Federal University of Technology Owerri, P.M.B 1526 Owerri, Nigeria Opurum Christian C. 3 Department of Microbiology, Federal University of Technology Owerri, P.M.B 1526 Owerri, Nigeria Aguh Maureen N. 4 Department of Microbiology, Federal University of Technology Owerri, P.M.B 1526 Owerri, Nigeria Agrawal Uma Rani 1 Department of Zoology, CMP P G College, A constituent College of University of Allahabad, Allahabad-211002, UP, India Tripathi Jaya 2 Zoology Department, Iswar Saran P G College, A constituent College of University of Alllahabad-211002, UP, India Shrestha Gita 1 Mechi Multiple Campus, Bhadrapur, Jhapa, Nepal Singh Nanda Bahadur 2 Central Department of Zoology, Tribhuvan University, Kirtipur, Kathmandu, Nepal > Short Communication 2018 11 30 2020 05 10 Thalassemia and haemoglobinopathies are the most frequent monogenetic haemolytic disorders worldwide. Beta- thalassemia is an emerging global health burden. The study in the different ethnic groups of Nepal regarding incidence of various types of thalassemia is scarce, despite Nepal being included in the World Thalassemia Belt. The current study was done in the Koch Rajbanshi ethnic group of eastern Nepal to determine different varieties of thalassemia and haemoglobinopathies present in them. Three hundred (300) individuals were randomly selected for screening. The screening was done by complete blood count test and microscopical study of peripheral blood smear. The positive samples were further analysed by haemoglobin electrophoresis. Out of total 300 cases 57 cases (19%) showed abnormal red cell indices. Based on the level of haemoglobin A2 and haemoglobin E levels, 26 cases with HbE heterozygote/trait and 31 cases with HbE homozygote/ disease were diagnosed. Hence it was deciphered that haemoglobin variants are a common genetic problem in the Koch Rajbanshi ethnic group. 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