International Science Community Association International Research Journal of Biological Sciences 2278-3202 8 5 2019 05 10 Lead induced changes in protein contents of kidney, liver, muscles and ovary of tilapia, Oreochromis mossambicus (Peters) 17 20 EN Mishra S. 1 Department of Biomedical Science, Shaheed Rajguru College of Applied Sciences for Women, University of Delhi, Delhi-110096, India Khatri M. 2 Department of Biomedical Science, Shaheed Rajguru College of Applied Sciences for Women, University of Delhi, Delhi-110096, India Mehra V. 3 Department of Biomedical Science, Shaheed Rajguru College of Applied Sciences for Women, University of Delhi, Delhi-110096, India Mohd. Yousuf Paray* and Parminder Singh Dehar 1 Department of Zoology and Environmental Science, Punjabi University, Patiala-147002, India Dilip B. Meshram 1 Department of Zoology, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur-440033, India Suresh C. Masram 2 Department of Zoology, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur-440033, India Vidya V. Baile 3 Department of Zoology, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur-440033, India > Research Paper 2018 12 31 2019 05 10 The present study aims to investigate toxicological effects of heavy metal, lead on protein contents of some tissues such as kidney, liver, muscles and ovary of a freshwater teleost, Oreochromis mossambicus. After LC50 determination, fish was exposed to one-third of LC50 as sublethal concentration for 10 days, it showed remarkable changes in protein profiles of all these tissues. Diminution of total proteins in kidney, liver, muscles and ovary was significantly observed (p<0.05). Compared to those in controlled fish, depletion of total proteins was found to be 6.85 % in kidney, 27.40% in liver, 45.23% in muscles and 6.60% in the ovary of experimental fish. Results showed that toxicity of lead to fish tissues was in the order muscles& Copyright@ International Science Community Association