International Science Community Association International Research Journal of Biological Sciences 2278-3202 8 4 2019 04 10 Phytochemistry analysis and modulatory activity of Portulaca oleracea and Aquilaria malaccensis extracts against High-fructose and high-fat diet induced immune cells alteration and heart lipid peroxidation in Rats 6 11 EN Abdullahi J.M. 1 Biology Department, Kano University of Science and Technology, Wudil, P.M. B. 3244, Kano Nigeria Samir Derouiche 1 Department of Cellular and Molecular Biology, Faculty of natural sciences and life, University of ElOued, El-Oued 39000, Algeria Ouidad Degachi 2 Department of Cellular and Molecular Biology, Faculty of natural sciences and life, University of ElOued, El-Oued 39000, Algeria Khaoula Gharbi 3 Department of Cellular and Molecular Biology, Faculty of natural sciences and life, University of ElOued, El-Oued 39000, Algeria > Research Paper 2018 9 9 2019 04 10 Our objective of this investigation is to estimate the influence of Portulaca oleracea (P. oleracea) and Aquilaria malaccensis (A. malaccensis) methanol extracts on High-fructose-fat diet (HFFD) induced immune cells alteration and heart lipid peroxidation in Rats. Twenty five Females rats were equally divided into five groups (n=5) as control, HFFD, HFFD+Po, HFFD+Am and HFFD+Po+Amgroups. High fructose-fat diet was addes in diet of rats with (60% fructose and 60% kcal fat) for 70 days. Methanol extracts of P.oleracea (Po) (400mg/kg bw) and A.malaccensis (Am) (200mg/kg bw) were supplemented orally for four weeks. Methanol extracts of plants were prepared and phytochemicals were analyzed by using HPLC methods. Hematological markers and lipid peroxidationin heart were assessed. Results obtained shown that HFFD induction caused a significant increase in White blood cell (& Copyright@ International Science Community Association