International Science Community Association International Research Journal of Biological Sciences 2278-3202 8 3 2019 03 10 Screening of agricultural wastes for Glutaminase biosynthesis via Solid-state fermentation 26 28 EN Noura E. Abd El-Hameed 1 Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt Haiam A. Mohammed 2 Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt El-Badry A.A. 3 Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt Hamada M.M.Z. 4 Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt Esmail Noghanchi 1 Department of Biology, Faculty of Science, University of Guilan, Rasht, Iran Hossein Javanbakht 2 Department of Biology, Faculty of Science, University of Guilan, Rasht, Iran Meghna Shrivastava 1 Faculty of Biological and Chemical Sciences, MATS University, Raipur, (C.G), India Ashish Saraf 2 MATS School of Biological and Chemical Sciences, MATS University, Raipur (C.G), India Aishwarya Sekar 1 Department of Bioinformatics, Stella Maris College, Cathedral Road, Chennai-600086, Tamil Nadu, India Nargis Begum 2 Department of Biotechnology, Jamal Mohammed College, Tiruchirappalli, India, nargisalmas Anita Margret 3 gmail.com Srikanth Manipati 1 Department of Oncology, NRI Academy of Sciences, Mangalagiri Road, Chinakakani-522503, Andhra Pradesh, India Chanakya Pallem 2 Department of Microbiology, Ganesh Scientific Research Foundation (GSRF), Kirti Nagar, New Delhi-110015, India > Short Communication 2018 11 24 2019 03 10 An incredible increase in the world’s population has led to the generation of million tons of agro-industrial wastes, which are in turn a great source of several bioactive metabolites such as therapeutic enzymes namely glutaminases. The enzyme has got immense potential applications across various industries varying from pharmaceutical to food. With the onset of scientific innovations, the usage of these nutritionally rich agricultural wastes for the synthesis of many valuable compounds significantly minimizing the production cost and pollution load on environment. The current investigation is aimed to explore and evaluate these inexpensive agro-wastes for glutaminase production under solid-state fermentation using Aspergillus wentii NCIM 661 and Fusarium oxysporum NCIM 1008. All the agro-wastes supported good microbial growth with better enzyme productivity. But among them, the maximum enzyme yield was noticed with wheat bran (9.36U/gds) using Aspergillus wentii NCIM 661, and sesame oil cake (10.27U/gds) with Fusarium oxysporum NCIM 1008, leaving the other substrates as noteworthy alternatives for the synthesis of glutaminase enzyme. This work had established the economical use of agro-industrial wastes into valuable metabolites which has considerable promising economics and environmental meaning. Copyright@ International Science Community Association