International Science Community Association International Research Journal of Biological Sciences 2278 - 3202 6 9 2017 09 10 In-vivo study of stress oxidative and liver damage in rats exposed to acetate lead 1 6 EN Samir Derouiche 1 Department of Cellular and Molecular Biology, Faculty of natural sciences and life, ElOued University, El-Oued 39000, El-Oued, Algeria Zeghibe Khaoula 2 Department of Cellular and Molecular Biology, Faculty of natural sciences and life, ElOued University, El-Oued 39000, El-Oued, Algeria Gharbi Safa 3 Department of Cellular and Molecular Biology, Faculty of natural sciences and life, ElOued University, El-Oued 39000, El-Oued, Algeria Khelef Yahia 4 Department of Cellular and Molecular Biology, Faculty of natural sciences and life, ElOued University, El-Oued 39000, El-Oued, Algeria > Research Paper 2017 6 21 2017 09 10 Lead (Pb) is a very toxic divalent heavy metal that occurs and diffuses into nature and the environment through human activities. The aim of this study was to evaluate the structure and liver function in rats exposed to lead. Our experimentation is carried out on Ten female Wistar rats were divided into two groups (n=5). The first group of rats received normal diet and water (controls) and the second group of rats received normal diet and acetate lead-contaminated water (100 mg/kg b.w) for 70 days. On which we measured some biochemical parameters. Results of our study showed that, in comparison with the control rats, lead exposure caused, a significant reduction (p<0.001) in the body weight and a significant augmentation (p<0.001) in relative liver weight. In addition, Result showed that in Pb-intoxicated rats, an increase in serum transaminases and Alkaline phosphatase activities and a decrease of GOT and GPT activities in liver when compared with normal animal group. Results revealed also that acetate lead treatment in rats affected antioxidant defense system by decreasing GSH level and GST activity and increasing MDA concentration. Also, the results clearly showed that lead causes alterations of hepatic tissue in comparison with controls. In Conclusion, Results demonstrated the toxic effect of high-dose of lead by causing oxidative stress and damage in hepatic tissue. Copyright@ International Science Community Association