International Science Community Association International Research Journal of Biological Sciences 2278 - 3202 6 7 2017 07 10 A review on in vitro genotoxic effects of food Preservatives on Human Lymphocytes 15 18 EN Tushar S. Kelkar 1 Environmental Sciences Research Laboratory, Dept. of Botany, Wilson College, Mumbai – 400 007, University of Mumbai, Mumbai, India Satish A. Bhalerao 2 SICE Society’s Degree College of Arts, Science and Commerce, Jambhul Phata, Chikhloli, Ambernath (W) 421 505, University of Mumbai, Ambarnath, India Pranay Agarwal 1 Department of Life Sciences, K.C. College, D.N. Road, Churchgate, Mumbai 400020, India Chandan Das 2 Department of Life Sciences, K.C. College, D.N. Road, Churchgate, Mumbai 400020, India Olivia Dias 3 Department of Life Sciences, K.C. College, D.N. Road, Churchgate, Mumbai 400020, India Tejashree Shanbhag 4 Department of Life Sciences, K.C. College, D.N. Road, Churchgate, Mumbai 400020, India Ayesha Ameen 1 Department of Biological sciences, University of South Asia, Lahore, Pakistan Jalil Ahmad 2 Department of Biological sciences, University of South Asia, Lahore, Pakistan Shahid Raza 3 Department of Biological sciences, University of South Asia, Lahore, Pakistan Deep Patel 1 Department of Zoology, Gujarat University, Ahmedabad 380 009, India Riddhi Ramani 2 Disha Life Sciences Pvt. Ltd, Sr. Research Associate, Ahmedabad 380 051, India > Review Paper 2017 5 29 2017 07 10 Food Preservatives or other food additives are use to protect food from spoilage. Preservatives have hazards effects on human’s organs and also have effects on individual cell. The different concentration of preservatives affects the chromosomes which lead to chromosomal breakage. Human lymphocytes are used for Genotoxic study of preservatives. Micronucleus test, Sister Chromatid Exchanges and Chromosomal aberration studies are used. Lymphocytes cell culture carried out with 4-5 different concentrations of preservatives and results of different studies were comparing with control values. 24 and 48 hrs. treatments of preservatives are given to lymphocytes and from their results the range of concentration are prepared which cannot be hazards for human’s daily intake. This concentration range of preservatives can be later on approved by Food and Drug Administration. Copyright@ International Science Community Association