International Science Community Association International Research Journal of Biological Sciences 2278 - 3202 5 9 2016 09 10 Comparison and Phylogenetic Analysis of HIV retroviral Gag Poly Protein Precursors 32 37 EN Subhadra Subhadarsini 1 P.G. Department of Botany, Utkal University, Vani vihar, Bhubaneswar, Odisha, India Sandeep Kumar Nayak 2 P.G. Department of Botany, Utkal University, Vani vihar, Bhubaneswar, Odisha, India Kunja Bihari Satapathy* 3 P.G. Department of Botany, Utkal University, Vani vihar, Bhubaneswar, Odisha, India M. Udayakumar 1 Department of Botany, Pachaiyappa’s College, Chennai – 600 030, Tamil Nadu, India T.* Sekar 2 Department of Botany, Pachaiyappa’s College, Chennai – 600 030, Tamil Nadu, India Analyn* Anzano Cabras* 1 College of Arts and Sciences, University of Mindanao, Davao City, Philippines Jürgen Wiesner 2 Dresdener Ring 11, D-38444 Wolfsburg, Germany Mohamed Ahmed Fadl 1 Botany and Microbiology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt and Biology Department, Faculty of Science, Taif University, Taif, KSA Hira Mubeenand Shahid Raza 1 Faculty of Biological Sciences, Department of Biotechnology, University of South Asia, Lahore, Pakistan > Short Communication 2016 5 24 2016 09 10 The human immunodeficiency virus type I (HIV-1) is a member of retrovirus family, initially synthesized as the central and core domain of the Gag polyprotein. These polyprotein precursors are produced from the unspliced genomic RNA on free ribosomes within the cytoplasm. The entire process of membrane binding, particle assembly and maturation may occur sometimes in the absence of certain viral envelope proteins. Gag molecules generally gather and capture the viral RNA. After this, it migrates towards the inner cell membrane and assemble into immature viral particles of the cell. They are mainly involved in assembly of virus like particles. Analysis of retroviruses including HIV, SIV and their precursors reveals new insights to study their proper functioning and mechanism of action. In this study, sequence alignments were performed to analyze the similarity and phylogenetic analysis helped to know the evolutionary relationships among these protein precursors. For, this various bioinformatics tools was used for analysis which will help to study their function and also the structural level predictions. Copyright@ International Science Community Association