International Science Community Association International Research Journal of Biological Sciences 2278 - 3202 5 8 2016 08 10 Analysis of Cytochrome P51A1 gene, its Sequence Variants and Protein Domains 17 21 EN E. A. Ekundayo 1 Department of Biological Sciences, Afe Babalola University, Ado-Ekiti, Nigeria T. A. Ogunnusi 2 Department of Biological Sciences, Afe Babalola University, Ado-Ekiti, Nigeria O. O. Ogunmefun 3 Department of Biological Sciences, Afe Babalola University, Ado-Ekiti,Nigeria M. O. Alegbe 4 Department of Biological Sciences, Afe Babalola University, Ado-Ekiti, Nigeria A. O. Oso 5 Department of Chemical Sciences, Afe Babalola University, Ado-Ekiti, Nigeria Abhijeet Mahana 1 Department of Botany, Mizoram University, Aizawl-796004, Mizoram, India Shahid Raza 1 Department of Biotechnology, University of South Asia, Lahore, Pakistan Hira Mubeen 2 Department of Biotechnology, University of South Asia, Lahore, Pakistan > Research Paper 2016 5 15 2016 08 10 The cytochrome gene CYP51 is a member of the cytochrome P450 (CYP) gene super family and is mainly involved in synthesis of sterolby chemical reactions in certain plants and animals. CYP51 is commonly known across eukaryotes. The study is focused on functional analysis of human CYP51 gene, which is 22 kb in size with coding region consisting of 10 exons and present on chromosome number7 long arm position 7q21.2–q21.3. However, the comparison of the human CYP51 gene with other CYP gene families from different species shows 64 different CYP51 orthologues which are located at unique chromosomal positions. Computational analysis of CYP51 gene was performed to analyze its various orthologues, genetic variants, protein domains and signatures. Copyright@ International Science Community Association