International Science Community Association International Research Journal of Biological Sciences 2278-3202 13 4 2024 11 10 Development and Characterization of Glycyrrhizin Loaded Herbal Lozenges for Mouth Ulcer Treatment 31 36 EN Chaturvedi Prashant 1 Department of Biological Science, Rani Durgavati University, Jabalpur, MP, India Singh Divya 2 Department of Biological Science, Rani Durgavati University, Jabalpur, MP, India Pathak Renu 3 Department of Biological Science, Rani Durgavati University, Jabalpur, MP, India Beohar Purnima 4 Department of Biological Science, Rani Durgavati University, Jabalpur, MP, India ORTESE 1 Department of Microbiology, Joseph Sarwuan Tarka University, Makurdi, Benue State, Nigeria Aondover Raymond 2 Lin Su Su Mar 1 Department of Food Science, Mae Fah Luang University, Thailand and Department of Biotechnology, Mandalay Technological University, Mandalay, Myanmar and Department of Advanced Science and Technology, Nay Pyi Taw, Myanmar Myint Myo 2 Department of Biotechnology, Mandalay Technological University, Mandalay, Myanmar Chukeatirote Ekachai 3 Department of Food Science, Mae Fah Luang University, Thailand I. Mady Goma Dirat 1 Laboratoire de Recherche en Biologie et Ecologie Animales, Ecole Normale Supérieure, BP 69, Université Marien NGOUABI, Brazzaville, Congo and Faculté des Sciences Appliquées, Université DENIS SASSOU-N’GUESSO, udsn.cg Kintélé, Congo L.P. Boukama 2 Laboratoire de Recherche en Biologie et Ecologie Animales, Ecole Normale Supérieure, BP 69, Université Marien NGOUABI, Brazzaville, Congo A. Tsoumou 3 Laboratoire de Recherche en Biologie et Ecologie Animales, Ecole Normale Supérieure, BP 69, Université Marien NGOUABI, Brazzaville, Congo M. Mikia 4 Laboratoire de Recherche en Biologie et Ecologie Animales, Ecole Normale Supérieure, BP 69, Université Marien NGOUABI, Brazzaville, Congo H. Banga Mboko 5 Ecole Nationale Supérieure d’Agronomie et de Foresterie, BP 69, Université Marien NGOUABI, Brazzaville, Congo Macwan Carol P. 1 Faculty of Pharmacy, Dharmsinh Desai University, Nadiad, Gujarat, India Upadhyay Nandini P. 2 Faculty of Pharmacy, Dharmsinh Desai University, Nadiad, Gujarat, India Soni Tejal G. 3 Faculty of Pharmacy, Dharmsinh Desai University, Nadiad, Gujarat, India Suhagia B.N. 4 Faculty of Pharmacy, Dharmsinh Desai University, Nadiad, Gujarat, India > 2024 7 20 2024 11 10 Abrus precatorius Linn. A member of the Fabaceae family, this plant has numerous benefits. The seeds, roots, and leaves are used medicinally. The roots and leaves include astringent, pleasant, emetic, diuretic, and anthelmintic properties. The oral gel dosage form is extensively used in the treatment of mouth ulcers, but it has numerous disadvantages, including blistering, burning, itching, and skin irritation, as well as the fact that it can be swallowed and dissolve in the mouth. To address the aforementioned issue, herbal lozenges were made from Abrus precatorius L. leaves. Microscopy (powder research), morphology, extraction (maceration method), acidic isolation, and thin-layer chromatography were employed to prepare glycyrrhizin acid extract. Then hard lozenges were made and evaluated using a variety of procedures, including average weight and weight fluctuation, friability, hardness testing, disintegration, and moisture content measurement. The leaves contained fibers, trichomes, and xylems. The powder properties of Abrus precatorius leaves revealed the presence of glycyrrhizin. Glycyrrhizin was extracted from a water extract of leaves and identified using chemical testing and Thin Layer Chromatography. Then, lozenges were made in five batches. The first three batches had been consolidated, therefore only the fourth and fifth batches were evaluated. According to observations and data, the fourth batch of lozenges outperformed batch-5 in all tests. So, batch-4 lozenges are preferable. So it is concluded that the lozenge composition can outperform other formulations. Copyright@ International Science Community Association