International Science Community Association International Research Journal of Biological Sciences 2278-3202 13 3 2024 08 10 Oxidative stress biomarkers in liver of tilapia fish from New Gusau Reservoir, Zamfara State, Nigeria 15 20 EN M.G. Ajuru 1 Department of Plant Science and Biotechnology, Rivers State University, Nkpolu-Oroworuokwo, P.M.B. 5080, Port Harcourt, Rivers state, Nigeria V. Wilson 2 Department of Plant Science and Biotechnology, Rivers State University, Nkpolu-Oroworuokwo, P.M.B. 5080, Port Harcourt, Rivers state, Nigeria M. I. Ibrahim 1 Sheda Science and Technology Complex (SHESTCO), Abuja, Nigeria I.M. Alhassan 2 Department of Biochemistry, Bayero University Kano, Nigeria S. Abubakar 3 Sheda Science and Technology Complex (SHESTCO), Abuja, Nigeria S. M. Hafsat 4 Sheda Science and Technology Complex (SHESTCO), Abuja, Nigeria F.A. Umar 5 Sheda Science and Technology Complex (SHESTCO), Abuja, Nigeria H. Suleiman 6 Sheda Science and Technology Complex (SHESTCO), Abuja, Nigeria S. M. Alkasim 7 Sheda Science and Technology Complex (SHESTCO), Abuja, Nigeria Rabiu Sani Zurmi 1 Department of Biological Sciences, Federal University Gusau, Zamfara State, Nigeria Salisu Abubakar 2 Biotechnology Advance Research Center, Sheda Science and Technology Complex, P.M.B. 186, Garki, Abuja, Nigeria Shamsiya Muhammad Sani 3 Department of Biological Sciences, Federal University Gusau, Zamfara State, Nigeria > Research Paper 2024 1 26 2024 08 10 Fish can be utilized as bio indicators of environmental contamination since they are frequently employed as model organisms for evaluating the quality of aquatic environments. Purposive sampling was used to gather data on the surface water physicochemical quality of the New Gusau reservoir (NGR) and Nagwamatse farm (control) from nine sampling stations. In-situ measurements of pH, temperature (oC), conductivity (EC), total dissolved solids (TDS), dissolved oxygen (DO) and biological oxygen demand (BOD5) were carried out using a multifunctional meter. Standard water and wastewater system testing technique was used to examine the results. This study investigated the activities of SOD, CAT, reduced glutathione (GSH) content and MDA production in the organs of tilapia, tilapia, from New Gusau Reservoir (NGR).The reservoir is said to be contaminated since it receives effluents discharged from many industries. A clean fish farm (Nagwamatse farm) was employed as the control, and Tilapia weighing between 200g to 300g were taken from NGR. The liver of Tilapia from NGR showed a notable rise in Thiobarbituric acid (TBARS), superoxide dismutase (SOD), and catalase when compared with control. The findings showed that fish from the new Gusau reservoir had large concentrations of contaminants accumulating in their livers. This could be as a result of the high concentration of industrial activity close to the reservoir reflecting the degree of pollution in NGR. Copyright@ International Science Community Association