International Science Community Association International Research Journal of Biological Sciences 2278-3202 12 3 2023 11 10 The Role of Astrocytes in Alzheimer's disease 17 20 EN Alfred OUEDRAOGO 1 University Joseph Ki Zerbo; Laboratory of Histology, Embryology, Cytogenetics and Biology of Reproduction of the University Hospital of Bogodogo, Burkina-Faso Prudencio AGBOHESSI 2 University of Parakou; Research Laboratory in Aquaculture and Aquatic Ecotoxicology (LaRAEAq); Benin Léa GUEDEGBA 3 University of Parakou; Research Laboratory in Aquaculture and Aquatic Ecotoxicology (LaRAEAq); Benin Gisèle HOUEDJISSI 4 University of Parakou; Research Laboratory in Aquaculture and Aquatic Ecotoxicology (LaRAEAq); Benin Oumar BARRO 5 Mayo Clinic, Molecular Medicine/ Department of Hematology-Oncology, USA Alexis HOUNDJI 6 University of Parakou; Research Laboratory in Aquaculture and Aquatic Ecotoxicology (LaRAEAq); Benin Arlette DANDJINOU 7 University of Parakou; Research Laboratory in Aquaculture and Aquatic Ecotoxicology (LaRAEAq); Benin Ibrahim IMOROU TOKO 8 University of Parakou; Research Laboratory in Aquaculture and Aquatic Ecotoxicology (LaRAEAq); Benin Mahla Charmi 1 Bhagwan Mahavir College of Basic and Applied Science, Surat, Gujarat, India Pandya Trupti 2 Bhagwan Mahavir College of Basic and Applied Science, Surat, Gujarat, India Gopalakrishna Prarthana Kalerammana 1 Physiology discipline, Human Biology division, School of Medicine, International Medical University, Kuala Lumpur, Malaysia Jagadeesan Saravanan 2 Department of Anatomy, School of Medicine, Taylors University, Lakeside Campus, Selangor, Malaysia Naik Venkatesh R 3 Department of Preclinical Sciences, Faculty of Medicine and Health Sciences, University Tunku Abdul Rahman, Jalan Sungai Long, Bandar Sungai Long, Kajang, Selangor, Malaysia Sura Sreenivasulu 4 Department of Preclinical Sciences, University Tunku Abdul Rahman, Faculty of Medicine, and Health Sciences, Jalan Sungai Long, Bandar Sungai Long, Kajang, Selangor, Malaysia Rao Vishnumukkala Thirupathi 5 Anatomy discipline, Human Biology division, School of Medicine, International Medical University, Kuala Lumpur, Malaysia > Review Paper 2023 9 10 2023 11 10 Alzheimer's disease (AD) is a neurodegenerative condition that impairs cognition, causes memory loss, and alters a person's behaviour and personality. The deposit of amyloid-β (Aβ) plaques and hyperphosphorylated tau, which results in neurofibrillary tangles, in the brain are two important pathogenic characteristics of AD. Numerous investigations have determined and confirmed that astrocytes in AD have both neurotoxic and neuroprotective properties. The unique pathophysiological mechanisms and roles of these cells remain unknown despite several explanatory theories. The review outlines the neuroprotective roles of astrocytes, like as inflammation control and Aβ elimination. It concludes by highlighting the intricate interactions that exist between astrocyte activities and AD pathogenesis. Research on reactive astrocytes' balance between neuroprotection and neurotoxicity is still ongoing. Although there is now no treatment for AD, a better understanding of these pathways and therapeutic approaches that target astrocytes may be the key to developing more potent therapies for this debilitating illness. Copyright@ International Science Community Association