International Science Community Association International Research Journal of Biological Sciences 2278-3202 11 3 2022 08 10 A Review: Formulation approaches for targeted drug delivery of drugs for Rheumatoid Arthritis 20 24 EN Tripathi M. 1 Department of Zoology, S. P. M. Govt. P. G. College, University of Allahabad, Prayagraj-211013, India Agrawal U.R. 2 Department of Zoology, C.M.P. P.G. College, University of Allahabad, Prayagraj-211002, India Tripathi J. 3 Department of Zoology, Iswar Saran P. G. College, University of Allahabad, Prayagraj-211004, India Laishram Jogesh 1 Department of Forestry and Environmental Science, Pandit Deen Dayal Upadhyay Institute of Agricultural Sciences, Bishnupur District, Utlou-795134, Manipur, India Sharma Neeraj Kumar 1 Dept. of Zoology, Govt. Degree College Shahpur Himachal Pradesh, India Kola Muni Raja Lakshmi 1 Department of Pharmaceutics, S.V.U.C.S, S.V. University, Tirupati, AP-517501, India Asuntha G. 2 Department of Pharmaceutics, S.P.W. Polytechnic, Tirupati, AP-517501, India > Review Paper 2021 3 11 2022 08 10 The aim of the present review article is focus on current status of Rheumatoid arthritis and to present various novel approaches for development of formulations and the techniques without inherent of side effects of antiarthritic drugs such NSAID. Rheumatoid arthritis is an auto immune disorder which followed by inflammation and disorder in function also causes depression. By using anti-inflammatory drugs and immunosuppressants together it can be treated. These drugs possess high fatal risk as they have not targeted to the receptor site and thus it shows severe adverse effects. Due to low bioavailability of these drugs, the drug candidates are potentially used in too high doses which causes adverse effects. In order to overcome these adverse effects, to increase the bioavailability and also to induce sustain release targeted drug delivery system may considered to be useful. By using the targeted drug delivery system, specificity of drugs increases, which increases bioavailability and the dose of administered drug get reduced. Copyright@ International Science Community Association