International Science Community Association International Research Journal of Biological Sciences 2278 - 3202 1 5 2012 09 10 Effects of Mold Exposure on Murine Splenic Leukocytes 53 56 EN Bhosagar Dullav 1 Department of Environmental Sciences (Auto) Sambalpur University, Jyoti Vihar-768019, Orissa, INDIA BhoiLakshmikanti 2 Mishra P.C. 3 AlitonouGuy Alain 1 Lab. d’Etude et de Recherche en Chimie Appliquée, Ecole Polytechnique d’Abomey-Calavi, Université d’Abomey-Calavi, Cotonou BENIN Avlessi Felicien 2 Institut des Biomolécules Max Mousseron, IBMM UMR CNRS-UM1-UM2, ENSCM, rue de l’Ecole Normale, Montpellier cedex, FRANCE Yehouenou Boniface 3 KoudoroYaya Alain 4 MenutChantalandSohounhloue Dominique 5 DharaskarSwapnilA. 1 Department of Chemical Engineering, Visvesvaraya National Institute of Technology, Nagpur, MS, INDIA PatilRahul D. 2 Department of Chemical Engineering, Pravara Rural Engineering College, Loni, Ahmednagar, MS, INDIA Joseph Baby 1 nterdisciplinary Research Centre, Malankara Catholic College, Mariagiri, Kaliakkavilai- 629 153, Tamil Nadu, INDIA NairVrundhaM 2 Department of Bioinformatics, Malankara Catholic College, Mariagiri, Kaliakkavilai- 629 153, Tamil Nadu, INDIA Ch 3 ySusheel G. 4 ParamanathaSwamidoss D. 1 Department of Environmental Science, PSN College of Engg and Tech, Tirunelveli, Tamilnadu, INDIA SudhakaranM.R. 2 Department of Zoology, Sri Paramakalyani College, Alwarkurichi, Tamilnadu, INDIA Parvathiraj P. 3 SharmaP.K. 1 Department of Biotechnology, Himachal Pradesh University, Summer Hill, Shimla, INDIA Ch 2 D. 3 KhelkerTuneer 1 Department of Botany Govt. K.P.G. College Jagdalpur Bastar C.G, PIN 494001 INDIA Haque Nurul 2 PraveenKumarG.N. 1 Department of Biotechnology, Acharya Institute of Technology, Soladevanahalli, Bangalore-560 090, INDIA BhatSumangala K. 2 GorhamK. 1 Department of Science and Technology, Bryant University, Smithfield, RI, USA Hokeness K. 2 > Research Paper 2012 8 7 2012 09 10 The relationship between exposure to mold spores and human disease is only beginning to be understood. While evidence exists of strong correlations between moldy environments and allergic and infectious diseases, the relationship between exposure to specific species and human immune responses to them is not fully understood. This paper seeks to clarify this relationship by analyzing the effects of exposing murine splenic leukocytes to volatile organic compounds (VOCs) produced by different toxic mold species. Here we report that the VOC 1-octen-3-ol can have deleterious toxic effects on the splenic leukocytes and can initiate cytokine production by them which ultimately can contribute to illness including the hypersensitivity diseases that have been observed in individuals exposed to indoor mold for long periods of time. Copyright@ International Science Community Association