International Science Community Association International Research Journal of Biological Sciences 2278 - 3202 1 4 2012 08 10 Anti-angiogenic properties of the Jamaican ball moss, (Tillandsia recurvata L.) 73 76 EN Swaminathan C. 1 Tamil Nadu Agricultural University, Agricultural College and Research Institute, Madurai – 625 104, TN, INDIA VijendraRaoR. 2 Wood Properties and Uses division, Institute of Wood Science and Technology, Bengaluru – 560 003, Karnataka, INDIA Shashikala S. 3 Masih Usha 1 Department of Botany, Mata Jija Bai Govt. Girls P.G. College, Indore, MP, INDIA ShrimaliRagini 2 Department of Microbiology, I.K. Science College Indore, MP, INDIA Naqvi S.M.A 3 Department of Botany, I. K. Science College Indore, MP, INDIA Mehta Jitendra 1 Microbiology and Pathology Division, Vital Biotech Research Institute, University of Kota, Kota- 324009, Rajasthan, INDIA DhakerJayraj Kiran 2 Kavia Ambika 3 Sen Priya 4 KaushalNeha 5 Datta Sakshi 6 QuadrosGoldin 1 B.N. Bandodkar College of Science, Chendani, Thane 400601, Maharashtra, INDIA Athalye R.P. 2 álim Ali Centre for Ornithology and Natural History (SACON), Anaikatti Post, Coimbatore 641108, Tamil Nadu, INDIA Philippe Sessou 1 Laboratoire de Recherche en Biologie Appliquée (LARBA), Ecole Polytechnique d’Abomey-Calavi, Université d’Abomey-Calavi, Cotonou, BENIN Souaïbou Farougou 2 Laboratoire d’Etude et de Recherche en Chimie Appliquée (LERCA), Ecole Polytechnique d’Abomey-Calavi (EPAC), Cotonou, BENIN Guy Alitonou 3 Laboratoire de Microbiologie et de Biotechnologie Alimentaire, Faculté des Sciences Agronomiques (FSA), Cotonou, BENIN Sébastien Djenontin Tindo 4 Boniface Yèhouénou 5 Paulin Azokpota 6 Issaka Youssao 7 Dominique Sohounhloué 8 SaralaThambavaniD. 1 Department of Chemistry, Sri Meenakshi Government Arts College for Women (Autonomous), Madurai-625, INDIA Sabitha M.A. 2 Department of Chemistry, J.A. College for Women (Autonomous), Periyakulam-625 601, INDIA IllathSujina 1 * Department of Chemistry, Karpagam University, Coimbatore-641 021, INDIA Subban Ravi 2 PekGeok Pang 1 Faculty of Agro Based Industry, University Malaysia Kelantan (Jeli campus), Beg Berkunci No. 100, 17600 Jeli, Kelantan, MALAYSIA Asrul Af 2 Faculty of Earth science, University Malaysia Kelantan (Jeli campus), Beg Berkunci No. 100, 17600 Jeli, Kelantan, MALAYSIA i 3 Faculty of Agro Based Industry, University Malaysia Kelantan (Jeli campus), Beg Berkunci No. 100, 17600 Jeli, Kelantan, MALAYSIA RahmanShefiqur 4 ShahaRanajit kumar 5 Bhalerao S.N. 1 B.R. Gholap College, Sangvi, Pune, MS, INDIA RokadeKedarB. 1 JJT University, Vidyanagari, Jhunjhunu, Rajasthan, INDIA MaliGajanan V. 2 Bharati Vidyapeeth’s M.B.S.K. Kanya Mahavidyalaya, Kadegaon, Dist. Sangli, MS, INDIA Leslie V.A. 1 Madras Research Centre of Central Marine Fisheries Research Institute, Chennai 600 028, INDIA MargaretMuthuRathinamA. 2 Department of Microbiology, Ethiraj College for Women, Chennai 600 006, INDIA Balasingh Anusha 3 DangwalL.R. 1 Herbarium and Plant Systematic Lab., H.N.B. Garhwal Central University, S.R.T. Campus, Badshahithaul, Tehri Garhwal, INDIA Singh Am 2 eep 3 Sharma Antima 1 Herbarium and Plant Systematic Laboratory, Department of Botany, H.N.B. Garhwal Central University, Tehri Garhwal, INDIA DangwalL.R. 2 Govt. P.G. College, New Tehri, Uttarakhand, INDIA Dangwal Mukta 3 HenryI.C. Lowe 1 Bio-Tech R and D Institute, Kingston, JAMAICA CharahT. Watson 2 Educational and Scientific Corporation, Florida, USA Simone Badal 3 Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA EugeneN. Ateh 4 Natural Products Institute, University of the West Indies, Mona, JAMAICA NgehJ.Toyang 5 Joseph Bryant 6 > Short Communication 2012 7 7 2012 08 10 The island of Jamaica is known for its rich biodiversity and its abundance of medicinal plants being used as ethno medicines. Given the high occurrence of cancer worldwide and the major source of the discovery of new lead molecules being medicinal plants, this research undertook to investigate the anti-angiogenic properties of a chloroform extract from the Jamaican ball moss previously shown to exhibit anti-cancer properties in our lab and its dicinnamate isolates,1,3-di-O-Cinnamoyl-glycerol (D1 ) and (E)-(2-(3-(3-(3,4-dimethoxyphenyl)acryloyloxy)-2-hydroxypropoxy)-2-oxoethyl)triphenylphosphoniumbromide (D2) along with known chemotherapeutic drug, paclitaxel. This was investigated using a modified version of the ex vivo aortic ring sprouting assay. Results show that angiogenesis was reduced in the presence of the chloroform crude extract at 20 µg.ml and 30 µg/ml and also in the presence of D1 at 10 µg/ml and 20 µg/ml when compared to the control. The results substantiate the promising anti-cancer properties of the Jamaican ball moss and may prove useful in anti-cancer agents’ drug discovery. Copyright@ International Science Community Association