International Science Community Association International Research Journal of Biological Sciences 2278 - 3202 1 3 2012 07 10 Phylogenetic Studies on tRNA Dependent Amidotransferase from Plasmodium Falciparum 20 24 EN Patel AnuradhaJitendra 1 Department of Zoology, Bhavans College, Andheri, Mumbai University, Mumbai, INDIA Thakor AkankshaPravin 2 Department of Biotechnology, N.B. Mehta Science College, Bordi, Mumbai University, Mumbai, INDIA Avlessi Félicien 1 Lab. d’Etude et de Recherche en Chimie Appliquée, Ecole Polytechnique d’Abomey-Calavi, Université d’Abomey-Calavi, Cotonou BENIN AlitonouGuy Alain 2 Institut des Biomolécules Max Mousseron, IBMM UMR, CNRS-UM1-UM2, ENSCM, rue de l’Ecole Normale, Montpellier cedex, FRANCE DjenontinT. Sébastien 3 Tchobo Fidele 4 Yèhouénou Boniface 5 MenutChantal 6 Sohounhloué Dominique 7 Radha K. 1 Department of Microbiology, Ayya Nadar Janaki ammal College, Sivakasi, Tamilnadu, INDIA Mahima R. 2 Department of Microbiology, V.H.N.S.N College, Virudhunagar, Tamilnadu, INDIA RamanathanG. 3 Thangap 4 ian V. 5 Bhatt T.K. 1 Department of Biotechnology, Central University of Rajasthan, Kishangarh, INDIA > Research Paper 2012 5 14 2012 07 10 Malaria remains the major concern in most of the developing countries. It is caused by the protozoan, Plasmodium, which is a member of apicomplexan. This family is characterized by the presence of plastid like structure known as apicoplast. Proteins and metabolic pathways of plastid are more like bacterial one. Protein tRNA-dependent amidotransferase (PfAdT) is one of the many proteins encoded by nuclear genome and targeted towards apicoplast. In this study, we have performed the phylogenetic analysis of tRNA-dependent amidotransferase with respect to other species from all the three domains of life. Results showed the closeness of PfAdT to the archaeal and human mitochondrial homolog. We hope that this observation would be valuable in defining evolutionary history of parasite and also in designing new chemotherapy against malaria parasite. Copyright@ International Science Community Association