International Science Community Association International Research Journal of Biological Sciences 2278 - 3202 1 1 2012 05 10 Structural Studies on Mitogen Activated Protein Kinase from Plasmodium Falciparum 42 46 EN Bi Shaziya 1 School of Studies in Zoology and Biotechnology, Vikram University, Ujjain, MP, INDIA Goyal P.K. 2 Mishra P.C. 1 P.G.Department of Environmental Sciences, Sambalpur University, Jyoti Vihar, Orissa, INDIA Dash A.K. 2 Environmental Engineering, Department of Civil Engineering, ITER ,SOA University ,Bhubaneswar, INDIA Khageswar Pradhan 3 NTPC ,Kaniha ,Angul ,Odisha, INDIA Namdhari B.S. 1 Department of Biotechnology, Chaudhary Devi Lal University, Sirsa, INDIA Rohilla S.K. 2 Department of Energy and Environmental Sciences, Chaudhary Devi Lal University, Sirsa, INDIA Salar R.K. 3 Gahlawat S.K. 4 Bansal P. 5 Saran A.K. 6 Goswami A.P. 1 Department of Biology, M.V.M. Science and Home Science College, Rajkot, Gujarat, INDIA Mankodi P.C. 2 Department of Zoology, Faculty of Science, The M.S. University of Baroda, Vadodara, Gujarat, INDIA Bhosale P.R. 1 Department of Environmental Science, Shivaji University, Kolhapur, MS, INDIA Chonde S.G. 2 Department of Microbiology, Rajaram College, Kolhapur, MS, INDIA Nakade. D.B 3 Raut P.D. 4 Bhatt T.K. 1 Department of Biotechnology, Central University of Rajasthan, Kishangarh, INDIA > Research Paper 2012 4 16 2012 05 10 Human malaria is caused by the apicomplexan, Plasmodium falciparum. Malaria causes the major health problems in most of the developing countries, including India. In addition, increased resistant against existing drugs of malaria, impose the identification of novel drug targets. Plasmodium kinome has been studied in detail so far, providing key insight into the major differences between human and malaria parasite kinases. Few kinases are essential in asexual life stage of the parasite and do not club together with human counterparts in phylogenetic tree. Mitogen-activated protein kinase-2 (Pfmap-2) is one of the two MAP kinases found in Plasmodium and essential for the asexual growth. In this study, we have structurally characterized the Pfmap-2 using in-silico homology modeling. Also the structural comparison was performed between parasite and human counterparts. In addition, active site of Pfmap-2 was identified using online tool. Together, we think that present study will definitely hasten the process of development of new and effective anti-malaria drugs. Copyright@ International Science Community Association