International Science Community Association International Research Journal of Biological Sciences 2278 - 3202 1 1 2012 05 10 Anthelmintic effect of Natural Plant (Carica papaya) extract against the Gastrointestinal nematode, Ancylostoma caninum in Mice 2 6 EN Bi Shaziya 1 School of Studies in Zoology and Biotechnology, Vikram University, Ujjain, MP, INDIA Goyal P.K. 2 > Research Paper 2012 4 2 2012 05 10 Infection with gastrointestinal nematode have severe consequences for the health of millions of people worldwide, and cause serious economic losses in live stock farming. Synthetic drug have been considered the most effective way of controlling parasite infections. But these drugs are expensive and sometime unavailable to people and show the side effect hence anthelmintic offer a simple, cheap, cost effective method of controlling parasites with no side effect. The purpose of this experiment was to study the anthelmintic activity of Carica papaya extract against Ancylostoma caninum in infection in mice. Two experiments were setup for this study, in experiment no. 1, two groups (A and B) and experiment no. 2, three groups (A, B and C) of mice were taken for larval recovery and mast cell & eosinophil counts respectively. Group A mice were treated with plant extract (Carica papaya) 0.2 ml/ mouse, on day -14 and -7 day before challenge infection and on day 0 mice were challenge with 500 A. caninum larvae. Group B mice were challenge only with dose of 500 Ancylostoma caninum larvae. Group C served as a non treated control. Results of plant extract treated mice clearly demonstrated a reduction of larvae in group (A) when compared with group (B) of mice. Large number of mucosal mast cell observed on day 16 in all groups. Eosinophil levels were markedly reduced in 24 days after challenge infection in all groups. The results suggest a potential role of Carica papaya extract as an anthelmintic activity against intestinal nematodes infection. Copyright@ International Science Community Association