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Anthelmintic and Food Supplementary Conscientiousness of Apitoxin in Poultry Model

Author Affiliations

  • 1Department of Zoology, K.V. Faculty of Science, Swami Vivekanand Subharti University, Meerut-250005 (UP), India

Res. J. Recent Sci., Volume 5, Issue (10), Pages 9-14, October,2 (2016)


The current investigation was conducted to analyze the anthelmintic and food supplementary activity of bee venom in poultry model. The crude apitoxin was collected by venom extractor (invented and developed by the scientists at University of Allahabad, India) from Indian honey bee, Apis indica, reared at work station by the application of mild electric shock. It is a shiny liquid dries up quickly when come in contact of air and hydrophilic in nature. Chemical constituent of apitoxin includes peptides as melittin, apamin, phospholipase-A2, hyaluronidase, histamine, heptapeptides, adolopin and apamine were separated and characterized by High Performance Liquid Chromatography (HPLC) and Mass Spectroscopy (MS). The anthelmintic and food supplement activity of different fractional doses of toxin was analyzed in vitro and applied in vivo in well designed control and experimental poultry bird models. The control group was kept on plain poultry feed, whereas the other four groups were supplied with various fractions of apitoxin to poultry feed. The average daily body weight was found to be increased for model supplemented with honey bee venom in comparison to control poultry model. The findings were substantiated and level of significance was calculated by biostastistical applications. Simultaneously on the other hand in vitro bio assay of bee venom against heterakid roundworms, recovered from same model were tested and applied in vivo in experimental poultry models. The constituents of bee venom (heptapeptides, 7Kda) play a significant key role in anthelmintic activity against heterakid nemic fauna of avian vertebrates. These finding gave an idea about better and managed poultry through supply of apitoxin in their daily diet that acts as food supplement as well as anthelmintic factor for newly born chicks and adults.


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