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Formulation and Evaluation of Lorazepam Fast Dissolving Tablets using Synthetic and Natural Disintegrants

Author Affiliations

  • 1 Parul Institute of Pharmacy, Limda, Gujarat, INDIA
  • 2 Babaria Institute of Pharmacy, Varnama, Gujarat, INDIA

Res. J. Recent Sci., Volume 4, Issue (IYSC-2015), Pages 185-191, September,2 (2015)

Abstract

The main objective of present work was to formulate and optimize the fast dissolving tablets of lorazepam using synthetic and natural disintegrants. Crossprovidone, Crosscarmellose Sodium, Sodium Starch Glycolate and Low-Substituted Hydroxypropylcellulose were used as synthetic super disintegrants from synthetic form. Fenugreek Mucilage and Plantago Ovata Mucilage were used as super disintegrants from natural source. Tablets were prepared by direct compression method and the formulation of tablets was optimized to get minimum disintegration time and maximum drug release. From in vitro dissolution and drug release studies, Crosscarmellose Sodium was found to be the best superdisintegrant at all concentrations as it showed maximum drug release; while Low substituted Hydroxypropylcellulose was found to be the poor superdisintegrant with least drug release. Plantago Ovata Mucilage and Fenugreek Mucilage were found to be better super disintegrant than L-Hydroxypropylcellulose, but poor than Crosscarmellose Sodium, Crossprovidone and Sodium Starch Glycolate.

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