International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN.  International E-Bulletin: Information/News regarding: Academics and Research

Study of Antioxidant and Antimicrobial Activity of Medicinal Plants Utilized in Cancer Treatment

Author Affiliations

  • 1Department of Biotechnology, Veer Narmad South Gujarat University, Udhana Magdhalla Road, Surat INDIA

Res. J. Recent Sci., Volume 4, Issue (IVC-2015), Pages 15-21, (2015)


In our modern society word Cancer is becoming very common as various types of Cancer are effecting large population worldwide. Need of hour is to find the effective treatment of these cancers through research on different plants which can be a good source of components effective in its treatment. The state of uncontrolled growth of cell is Cancer. Various species of plants have been used in the preparation of drugs utilized for the treatment of malignant diseases. Phytochemicals are the chemical substances producing definite physiological action on human body. They found to have antioxidants which are also called free radical scavangers protecting the cells from different types of Cancer. In our studies we have selected six medicinal plants as Aegle marmelos (Leaves), Vernonia anthelmintica (Seeds), Zingiber officinalis (Rhizome), Tinospora cordifolia (Stem) and Phyllanthus acidus (Leaves) of Gujarat region which are reported to have role in cancer therapy due to the presence of different phytochemicals like phenolics, tannins, flavonoids etc. Aqueous and Organic extracts of different parts of these plants were prepared. Antioxidant activity was measured through DPPH and ABTS radical scavenging assay and antimicrobial activity through Agar Well Diffusion method. Antimicrobial activity was tested on some disease causing microorganisms like Pseudomonas aeruginosa, Bacillus subtilis, Staphylococcus aureus, Micrococcus luteus, Salmonella typhii, Aspergillus niger and Penicillium notatum. DPPH assay had revealed that organic extract of Vernonia anthelmintica and aqueous extract of Zingiber officinalis was found to have IC50 values 124 and 132 g/ml respectively. Antimicrobial activity of different extracts had shown that maximum diameter of Zone of Inhibition (24mm at 1g/ml) was obtained with organic extract of Tinospora cordifolia. No antifungal activity was observed with any of the plant species extracts. It can be concluded from the studies that the extracts of all test six plants possessed significant antioxidant and antibacterial activities which conforms their role in cancer studies.


  1. Ali N., Juelich W., Kusnick C. and Lindequist U., Screening of Yemni medicinal plants for antibacterial and cytotoxic activities, J Ethnopharmacol., 74, 173-179(2001)
  2. Nair R., Kalariya T. and Chanda S., Antibacterial activity of some selected Indian medicinal flora. Turkish Journal of Biology; 29, 41-47 (2005)
  3. Nordqvist Christian, Ginger Kills Ovarian Cancer Cells, Medical News Today. Medi Lexicon International limited (2006)
  4. Dhanasekaran M., Baskar A.A., Ignacimuthu S., Agastian P. and Duraipandiyan V., Chemopreventive potential of Epoxy clerodane diterpene from Tinosporacordifolia against diethylnitrosamine induced hepatocellular carcinoma., Invest new drugs., 27(4), 347-55 (2009)
  5. Lee C., Peng Y., Cheng W.H, ChengH., Lai FNMT. and Chiu T.H., Hepatoprotective Effect of Phyllanthus in Taiwan on Acute Liver Damage Induced by Carbon Tetrachloride, AmericanJournal of Chinese Medicine; 30(3), 471- 482 (2006)
  6. Brand-Williams W., Cuvelier M.E. and Berset C., Use of free radical method to evaluate antioxidant activity. Lebensmittel Wissenschaftund Technologie,28, 2530(1995), 15-21 (2015)
  7. Arnao M.B., Cano A. and Acosta M., The hydrophilic and lipophilic contribution to total antioxidant activity, Food Chemistry,73, 239244 (2011)
  8. Cheesbrough, M., District Laboratory practical in tropical countries, Part 2., Cambridge university Press, Cambridge, UK., 137- 150 (2006)
  9. Blois M., Antioxidant determination by the use of stable free radicals. Nature., 26, 1199-1200(1958)
  10. Cao G., Sofic E. and Prior R., Antioxidant capacity of tea and common vegetables. J Agricult Food Chem., 3426-3431(1996)
  11. Matkowski A., Tasarz P. and Szypu\na E., Antioxidant activity of herb extracts from five medicinal plants from Lamiaceae, subfamily Lamioideae, J. Med. Plants Res,. 2, 321-330 (2008)
  12. Naik G., Priyadarsini K., Satav J., Banavalikar M., Sohoni P. and Biyani M., Comparative antioxidant activity of individual herbal components used in Ayurvedic medicine. Phytochemistry,63, 97-104 (2003)
  13. Siddique N.A., Mujeeb M., Ansari S.H., Ahmad S., Ali B. and Junaid A., Development of quality standards of Aegle marmelos L. leaves. Journal of Phytology,2(2), 36-43 (2010)
  14. Sasidharan I. and Nirmala M.A., Comparative chemical composition and antimicrobial activity of Fresh and dry Ginger oils (Zingiber officinales Roscoe) Int. J. Curr. Pharm. Res., 2(4), 40-43 (2010)