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A Mild and Environmentally benign Synthesis of Benzimidazoles: Relevance to the pectin hetero Polysaccharide as a Catalyst

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Author Affiliations

  • 1 Organic Synthesis Laboratory, Department of Chemistry, CBSH, G.B. Pant University of Agriculture and Technology, Pantnagar (U.S.Nagar) -263145, Uttarakhand, INDIA

Res. J. Recent Sci., Volume 3, Issue (IVC-2014), Pages 64-67, (2014)

Abstract

We have developed a green procedure by using benzaldehyde and o-phenylene diamine as the model substrate, hetero polysaccharide pectin as a catalyst and water as a solvent. The generality and scope of this protocol was determined by synthesizing various derivatives of benzimidazole in good to excellent yield through this environment friendly, time and energy saving, green method.

References

  1. Kalyankar T.M., Pekamwar S.S., Wadher S.J., Tiprale P.S. and Shinde G.H., Review on Benzimidazole Derivative, International J. of Chemical and Pharmaceutical science, 3(4), 1-10 (2012)
  2. Ingle R.G., Magar, Heterocyclic Chemistry of Benzimidazoles and potential activities of derivatives, International J. of drug Research and Technology, 1(1), 26-32 (2011)
  3. Shaharyar M., Mazumder A., Salahuddin, Garg R. and Pandey R.D., Synthesis, characterization and pharmacological screening of novel benzimidazole derivatives, Arabian J. of chemistry, (2011)
  4. Nezhad A.K., Soltani Rad M.N., Mohabatkar H., Asrari Z. and Hemmateenezad B., Design, synthesis, antibacterial and QSAR studies of benzimidazole and imidazole chloroaryloxyalkyl derivatives, Biorganic and medicinal chemistry, 13, 1931-1938, (2005)
  5. Chavan B.B., Chitte P.D., Choudhary N.P., Albhar K.G. and Hukkeri V.I., Synthesis and biological evaluation of novel Benzimidazole derivative with aspirin as potent antimicrobial and antifungal agents, IJSRR,1(3), 22-30(2012)
  6. Gellis A., Kovacic H., Boufatah N. and Vanelle P., synthesis and cytotoxicity evaluation of some benzimidazole-4,7-diones as bioreductive anticancer agents, Eur. J. of med. Chem., 43, 1858-1864 (2008)
  7. Shukla J.S., Saxena S., Rastogi R., synthesis and anthelmintic activity of 1-(5’ substituted phenoxy methyl,1’3;4’-Thiadiazol-2’yl),2-methyl-4-substituted-benzylideneimidazol-5-ones,Current Science, 51, 817-820(1982)
  8. Sondhi S.M., Rajvanshi S., Johar M., Bharti N., Azam A. and Singh A.K., Anti-inflammatory, analgesic and antiamoebic activity evaluation of pyrimido [1,6-a] benzimidazole derivatives synthesized by the reaction of ketoisothiocyanates with mono and diamine, Eur.J.of Med. Chemistry, 37, 835-843 (2002)
  9. Bariwal J.B., Shah A.K., Kathiravan A.K., Somani R.S., Jagtap J.R. and Jain K.S., Synthesis and Antiulcer activity of novel pyrimidylthiomethyl-and pyrimidylsulinylmethyl benzimidazoles as potentialreversible proton pump inhibitors, Indian J. of pharm.ed.Res., 42(3), 225-231(2008) , 64-67 (2014)
  10. Kidwai M., Jahan A. and Bhatnagar D. Polyethylene glycol: A recyclable solvent system for the synthesis of benzimidazole derivatives using CAN as a catalyst, 122, 607-612 (2010)
  11. Lopez S.E., Restrepo J., Prerez B., Ortiz S. and Salazar J., One Pot Microwave Promoted Synthesis of 2-Aryl-1H-Benzimidazoles Using Sodium Hydrogen Sulfite, Bull. Korean Chem. Soc., 30, 1628-1630 (2009)
  12. Xiangming H., Huiqiang M. and Yulu. W., P-TsOH Catalyzed synthesis of 2-arylsubstituted benzimidazoles,ARKIVOC, Xiii150-154 (2007)
  13. Mobinikhaledi A., Forughifar N. and Kalhor M. An efficient synthesis of shiff bases containing benzimidazole moiety catalyzed by Transition metal nitrates, Turk J. Chem 34, 367-373 (2010)
  14. Patil V.D., Medha G., Sharmesha M. and Jaiswal A., A mild and efficient synthesis of benzimidazole by using lead peroxide under solvent free condition, Dev Chemica Sinica, 1(2), 125-129 (2010)
  15. Pagadala R., Gandhare N.V., Kusumpally U., Jetti V., Meshram J.S. and Juneja H.D., Synthesis of 1H-Imidazoles Catalyzed by Cu-Nanoparticle and Its Physicochemical Properties, J. of Hetrocyclic Chem.51, 116-122 (2010)
  16. Vaidehi B.N.B., Deepika K.G, Synthesis and biological evaluation of 2-substituted benzimidazoles, International J. of Pharma and Bio Sciences, 3(3), 26-31 (2012)
  17. Khaksar S., Heydari A., Tajbakhsh M., Vahdat S.M., Lewis acid catalyst free synthesis of benzimidazoles and formamidines in 1,1,1,3,3,3-hexafluoro-2-propanol, J. of Fluorine Chem., 131, 1377-1381 (2010)
  18. Kathirvelan D., Yuvaraj P., Babu K., Nagarajan A.R. and Reddy B.S.R., A green synthesis of benzimidazoles, Indian J. of Chemistry, 52B, 1152-1156 (2013)
  19. Sharma C.K. and Kanwar S.S., Synthesis of methyl cinnamate using immobilized lipase from B. licheniformis MTCC-10498, Research J. of Recent Science, 1(3), 68-71(2012)
  20. Gangwar N. and Kasana V.K., 3,4-Dihydropyrimidin-2(1)-one derivatives: Organocatalysed microwave assisted synthesis and evaluation of their antioxidant activity, Med Chem. Res., 21(12), 4506-4511 (2012)
  21. Bello Y., Makama, Regioselective synthesis of Butenoildes Mediated by Silvertrifluroacetate with B-Halo Acetals, Research J. of Recent Science, 1(1), 85-88 (2012)
  22. Montazerozohori M., Musavi S.A.R. and Joohari S., Synthesis, Characterization and Thermal behavior of some New Mercury and Cadmium halides Coordination compounds of Recently synthesized Schiff base, Research J. of Recent Science, 1(11), 9-15 (2012)
  23. Rahmouni A., Harrane A. and Belbachir M., Mechanochemical Synthesis And Characterization of Polyaniline catalyzed by Maghnite-H (Algerian Montmorillonite), Research J. of Recent Science, 2(10), 1-5 (2013)
  24. Rashidi N.A. and Berad B.N., Synthesis of some novel 1,3,4-Oxadiazole derivatives, Research J. of Recent Science,2(ISC-2012), 10-12, (2013)
  25. Rathee P.S., Dhankar R., Bhardwaj S., Gupta M. and Kumar R., Synthesis and Antimicrobial studies of novel Benzimidazole derivatives. J. of Applied Pharmaceutical Science,01(04), 127-130 ( 2011)
  26. Budow S., Kozlowska M., Gorska A., Kazimierczuk Z., Eickmeier H. Colla P.L., Gosselin G. and Seela F. Substituted benzimidazoles: antiviral activity and synthesis of nucleosides, ARKIVOC, (iii) 225-250(2009)