International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN.  International E-Bulletin: Information/News regarding: Academics and Research

Production of Monoclonal Antibodies: An Overview

Author Affiliations

  • 1Department of Studies in Zoology, University of Mysore, Manasagangotri, Mysore, INDIA

Res. J. Recent Sci., Volume 3, Issue (8), Pages 119-124, August,2 (2014)


On the account of evolutionary aspects, adaptation to new environmental changes made almost all organisms including pathogens to undergo de novo mutagenesis. Human immunodeficiency virus is clear cut substantiation for this statement. In addition, due to maltreatment of antibiotics increases risk of resistance in the next generations. Consequently, production of monoclonal antibodies with precise detection efficiency is indispensable. In this context, new technologies should be developed to generate specific accurate antibodies at maximum possible economical rate to attend the demand of academic and clinical researches. Making use of plants and microorganisms seems to be more efficient rather conventional methods.


  1. Miroslaw K.G., Human Hybridoma Technology, Antibody. Tech. J., (2), 1-5 (2012)
  2. Richard A.G., Thomas J.K. and Barbara A.O., Kuby Immunology book (4th edition), W.H. Freeman and Co., NY,(2000)
  3. Karpas A., Dremucheva A. and Czepulkowski B. H., A Human Myeloma Cell Line Suitable for the Generation of Human Monoclonal Antibodies, Proc. Nat. Acad. Sci. USA., 98(4), 1799-1804 (2001)
  4. Jitendra R., How Monoclonal Antibodies are Produced In Vitro, URL: (2010)
  5. Monoclonal Antibody Technology The Basics (BIO). "What is Biotechnology?" Washington, D.C.: Biotechnology Industry Organization, (1989)
  6. Michael R. and Bishop M.D., Monoclonal Antibodies, FACP. The Cancer Library., URL: http://
  7. Garber K., Biotech Industry Faces New Bottleneck, Nature Biotech, 19(3), 184-185 (2001)
  8. Claire P., Molecular guided missiles called monoclonal antibodies were poised to shoot down cancer and a host of other diseases--until they crashed and burned. Now a new generation is soaring to market, Sci.American.,9(10), 36-41, (2001)
  9. Georgy A.N., Olga O.F. and Valentina N.B., Catalyeic Antibodies: New Characters in the Protein Repertoire, Protein-protein interactions: A Molecular Cloning Manual, Cold Spring Harbor Laboratory Press, Chapter 29, 523-534, (2002)
  10. Shah Manisha N. and Desai Pratibha B., Emergence of multidrug resistant Klebsiella pneumonia in neonatal Intensive Care Units: concern about antimicrobial policies, Res. J. Recent Sci., 1(ISC-2011) , 275-280 (2012)
  11. Panchal Hetal K. and Desai Pratibha B., Evaluation of one Rapid Method for Diagnosis of Malaria The Optional and Better Replacement of MicroscopyRes. J. Recent Sci.,1(ISC-2011) , 361-364 (2012)