International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN.  International E-Bulletin: Information/News regarding: Academics and Research

Investigation of the Zinc Oxide Nanoparticles Effect on Testosterone, Cholesterol and Cortisol in Rats

    , , , , ,

Author Affiliations

  • 1Department of Biology, Faculty of Sciences, Payam Noor University of Iran, Employee social security, Isfahan, IRAN
  • 2Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, IRAN
  • 3Department of Biochemistry, Faculty of Biological Science, Tarbiat Modares University, Tehran, IRAN
  • 4 Department of Biology, Faculty of Sciences, Payam Noor University of Iran, Isfahan, IRAN
  • 5Physiology Research Center, Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical

Res. J. Recent Sci., Volume 3, Issue (4), Pages 14-19, April,2 (2014)

Abstract

Nowadays nanoparticles have widespread application in various industries because of their special and unique features. There are many studies in side effects of nanomaterial but these studies used from high doses and specially ZnOnanoparticles in low dose was less researched. This study done by 36 Wistar rats with every other day injection of different doses of ZnOnanoparticles intraperitoneally (5, 10, 20 and 40 mg / kg). After a 21-day period, the rats were bled and whole blood hematocrit and lymphocyte numbers and serum levels of cholesterol, cortisol and testosterone hormone were measured. The results showed a significant decrease of cortisol level and significant increase of testosterone and cholesterol level of blood serum in rats that injected by ZnOnanoparticles rather than controls. Number of lymphocyte in treated rats reduced and hematocrit showed an irregular variation. Therefore all of results confirmed exposing to ZnOnanoparticles damaged to public health and reduced fertility potential.

References

  1. Aaseth J., Olsen A., Halse J. and Hovig T., Argyria- Tissue Deposition of Silver as Selenide, Scand .J. Clin. Lab. Invest,41(3), 247-51(1981)
  2. Paull R., Wlfe J., Hebert P. and Sinkula M., Investing in Nanotechnology, Nature, Bioethanol, 21(10), 1144-1147 (2003)
  3. Yoshida Y., Itoh N., Saito Y., Hayakawa M. and Niki E., Application of Water-Soluble Radical Initiator, 2,20-Azobis-[2-(2-Imidazolin-2-Yl) Propane] Dihydrochloride, to A Study Of Oxidative Stress, Free, Radical Research, 38(4), 375–384 (2004)
  4. Brandt D., Park B., Hoang M. and Jacobe HT., Argyria: Secondary to Ingestion of Homemade Silver Solution, J. Am. Acad. Dermotal, 53, 105-107 (2005)
  5. YousefiBabadi V., Amraeai E., Salehh H., Sadeghi L., Najafi L., Fazilati M., Evaluation of Iron Oxide nanoparticles effects on tissue and Enzymes ofThyroid in Rats, Int. Res. J. Biological Sci,, 67-69 (2013)
  6. Heinlaan M., Ivask A., Blinova I., Dubourguier HC. andKahru A., Toxicity of Nanosized and Bulk ZnO , Cuo and Tio2 to Bacteria Vibrio Fischeri and Crustaceans Daphnia Magna and ThamnocephalusPlatyurus, J. Chemosphere,71(7), 1308-1316 (2008)
  7. Esmaeillou M., Moharamnejad M., Hsankhani R., Tehrani AA. andMaadi H., Toxicity of ZnO Nanoparticles in Healthy Adult Mice, Environ. Toxicol.Phar, 35(1), 67-71 (2013)
  8. Meyer K., Rajanahalli P., Ahamed M., Rowe JJ. and Hong Y., ZnO Nanoparticles Induce Apoptosis in Human Dermal Fibroblasts Via P53 And P38 Pathways, Toxicol. InVitro.,25(8), 1721-6 (2011)
  9. Umrani RD. and Paknikar KM., Zinc Oxide Nanoparticles Show Antidiabetic Activity in streptozotocin-Induced Types-1 And 2 Diabetic Rats, Nanomedicine (Lond) , 1-16 (2013)
  10. Hanley C., Layne J., Punnoose A., Reddy KM., Coombs I., Coombs A., et al., Preferential Killing of Cancer Cells and Activated Human T Cells Using Zno Nanoparticles, Nanotechnology, 19(29), 295103 (2008)
  11. Akhtar MJ., Ahamed M., Kumar S., Khan MM., Ahmad J. and Alrokayan SA., Zinc Oxide Nanoparticles Electively Induce Apoptosis in Human Cancer Cells Through Reactive Oxygen Species, Int. J. Nanomedicine, , 845–57 (2012)
  12. Huang Z., Zheng X., YanD., Yin G., Liao X., Kang Y., Yao Y., Huang D. and Hao B., Toxicological effect of ZnO nanoparticles based on bacteria, Langmuir,24(8), 4140-4144 (2008)
  13. Liu Y., He L., Mustapha A., Li H., Hu ZQ. and Lin M., Antibacterial Activities of Zinc Oxide Nanoparticles Against Escherichia Coli O157:H7, J. Appl. Microbiol,107(4), 1193-201 (2009)
  14. Jones N., Ray B., Ranjit KT. and Manna AC., Antibacterial Activity of Zno Nanoparticles Uspensions on A Broad Spectrum of Microorganisms, FEMS, Microbiol.Lett.,279(1), 71-6 (2008)
  15. Guo D., Bia H., Wang D. and Wu Q., Zinc Oxide Nanoparticles Decrease the Expression and Activity of Plasma Membrane Calcium ATPase, Disrupt The Intracellular Calciumhomeostasis in Rat Retinal Ganglion Cells, Int. J. Biochem. Cell B,45 (8), 1849– 1859 (2013)
  16. Han D., Tian Y., Zhang T., Ren G. and Yang Z. Nano-Zno Damages Spatial Cognition Capability Via Over-Enhanced Long-Term Potentiation in Hippocampus of Wistar Rats, Int. J. Nanomedicine, (6), 1453–1461 (2011)
  17. Monteiro-Riviere NA., Wiench K., Landsiedel R., Schulte S., Inman AO. andRiviere JE., Safety Evaluation of Sunscreen Formulations Containing Titanium Dioxide and Zno Nanoparticles in UVB Sunburned Skin: An In Vitro and In Vivo Study, Toxicol. Sci, 123(1), 264–280 (2011)
  18. Landsiedel R., Ma-Hock L., Van Ravenzwaay B, et al., Gene toxicity Studies on Titanium Dioxide and ZnoNanomaterials Used for UV-Protection in Cosmetic Formulations, Nanotoxicology, , 364–381 (2010)
  19. Espanani H. R, Fazilati M., Sadeghi L., YousefiBabadi V., Bakhshiani S. Amraie E., Investigation the Zinc Oxide Nanoparticle’s Effect on Sex Hormones and Cholesterol in Rat, Int. Res. J. Biological Sci,, 1-6 (2013)
  20. Hanley C., Thurber A., Hanna C., Punnoose A., Zhang J. and Wingett DG, The Influences of Cell Type and Zno Nanoparticles Size On Immune Cell Cytotoxicity and Cytokine Induction, Nanoscale, Res. Lett,4(12), 1409–1420 (2009)
  21. Valdiglesias V., Costa C., Kilic G., Costa S., Pasaro E., Laffon B., et al, Neuronal Cytotoxicity and Genotoxicity Induced by Zinc Oxide Nanoparticles, Environ. Int, (55), 92-100 (2013)
  22. Hanley C., Thurber A., Hanna C., Punnoose A., Zhang J. and Wingett DG. The Influences of Cell Type and ZnO Nanoparticles Size on Immune Cell Cytotoxicity and Cytokine Induction, Nanoscale, Research Letters, 4(12), 1409-1420 (2009)
  23. Ostrowsaka J.G., Effect of Dietary Fat on Androgen Secretion and Metabolism, Reprod. Biol, (6), 13-21 (2006)
  24. Roshanai K., Razavian MH., Ahmadi R., Heidarieh N. and Masaeemanesh MB., The Effect of Silvernano Oral Consumption on some Hormonal, Hematological and Urine Parameters of Vistar Rats, Qom University of Medical Sciences Journal, 6(3), 65-70 (2012)