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Investigation of the Zinc Oxide Nanoparticles Effect on Testosterone, Cholesterol and Cortisol in Rats

Author Affiliations

  • 1Department of Biology, Faculty of Sciences, Payam Noor University of Iran, Employee social security, Isfahan, IRAN
  • 2Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, IRAN
  • 3Department of Biochemistry, Faculty of Biological Science, Tarbiat Modares University, Tehran, IRAN
  • 4 Department of Biology, Faculty of Sciences, Payam Noor University of Iran, Isfahan, IRAN
  • 5Physiology Research Center, Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical

Res. J. Recent Sci., Volume 3, Issue (4), Pages 14-19, April,2 (2014)


Nowadays nanoparticles have widespread application in various industries because of their special and unique features. There are many studies in side effects of nanomaterial but these studies used from high doses and specially ZnOnanoparticles in low dose was less researched. This study done by 36 Wistar rats with every other day injection of different doses of ZnOnanoparticles intraperitoneally (5, 10, 20 and 40 mg / kg). After a 21-day period, the rats were bled and whole blood hematocrit and lymphocyte numbers and serum levels of cholesterol, cortisol and testosterone hormone were measured. The results showed a significant decrease of cortisol level and significant increase of testosterone and cholesterol level of blood serum in rats that injected by ZnOnanoparticles rather than controls. Number of lymphocyte in treated rats reduced and hematocrit showed an irregular variation. Therefore all of results confirmed exposing to ZnOnanoparticles damaged to public health and reduced fertility potential.


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