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Role of Proteus mirabilis in Caffeine Degradation–A Preliminary Bioinformatics Study

Author Affiliations

  • 1 School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, INDIA

Res. J. Recent Sci., Volume 2, Issue (ISC-2012), Pages 33-40, February,2 (2013)


An attempt to find the role of Proteus mirabilis in caffeine degradation using bioinformatics tools has been made here. Soils from coffee industries were taken and the bacterium was isolated and found to degrade caffeine. Identification of the bacterium through Sangers dideoxy sequencing of 16S rDNA was done and its genome taken from online database was used for homology modeling of the enzyme to identify regions of similarity and enzyme structure prediction. Also attempts to secondary structure prediction and protein threading has been done to study the enzyme and compare the enzymes of Proteus mirabilis with that of other reported caffeine degrading organisms.


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