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Biological Evaluation of 1, 3-Bis-(2- Substitutedamino-6-Substitutedimino-1, 3, 5- Thiadiazin- 4- yl)-Thiourea Derivatives as Antimicrobial agents

Author Affiliations

  • 1 H.V.P.M.’s College of Engineering and Technology Amravati M.S., INDIA

Res. J. Recent Sci., Volume 2, Issue (ISC-2012), Pages 13-14, February,2 (2013)


A series of 1,3-bis (2- substitutedamino-6-substituted-imino-1,3,5-thiadiazin- 4- yl)-thiourea [3a(i) to 3f (iii)] have been obtained by basification of their hydrochlorides [2a(i) to 2f (iii)].The latter were synthesized by the interaction of 1,3-bis (N-substitutedamidinothiocarbamido)- thiourea (1) and N-aryl/alkylisocyanodichlorides in 1:2 molar ratio. The compound (1) was prepared initially by the condensation of aryl/alkylisothiocyanate and 1,3-diformamidinothiourea in 1:2 molar ratios. The structure of all these compounds was established on the basis of IR and NMR spectral data. All the synthesized compounds have been assayed for their antibiological activity against both gram-positive and gram-negative human pathogens and found that they possess insecticidal, and bacteriocidal. Some 1,3,5-thiadiazine compounds show remarkable biological activity.


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