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Synthesis of some Novel 1,3,4-Oxadiazole derivatives

Author Affiliations

  • 1 Post Graduate Department of Chemistry, Shri Shivaji Science College Amravati, (M.S) INDIA
  • 2 Department of Chemistry, RTM Nagpur University, Nagpur PINCode-440033, (M.S) INDIA

Res. J. Recent Sci., Volume 2, Issue (ISC-2012), Pages 10-12, February,2 (2013)

Abstract

A series of N-(4-chlorophenyl) amino-5-aryl-1,3,4-oxadiazole (IVa-f) have been synthesized by the condensation of acid hydrazides (Ia-f) and 4-(chlorophenyl) isocyanodichloride (II). Six different aromatic acid hydrazides were obtained by the estrification of aromatic acid followed by treatment with hydrazine hydrate. The compound (II) was prepared by the exhaustive chlorination of p-chloro isothiocyanate. Structures of all the newly synthesized compounds were confirmed by physical characterization and IR and NMR and Mass spectral analysis.

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