International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN.  International E-Bulletin: Information/News regarding: Academics and Research

Synthesis of some Novel 1,3,4-Oxadiazole derivatives

Author Affiliations

  • 1 Post Graduate Department of Chemistry, Shri Shivaji Science College Amravati, (M.S) INDIA
  • 2 Department of Chemistry, RTM Nagpur University, Nagpur PINCode-440033, (M.S) INDIA

Res. J. Recent Sci., Volume 2, Issue (ISC-2012), Pages 10-12, February,2 (2013)


A series of N-(4-chlorophenyl) amino-5-aryl-1,3,4-oxadiazole (IVa-f) have been synthesized by the condensation of acid hydrazides (Ia-f) and 4-(chlorophenyl) isocyanodichloride (II). Six different aromatic acid hydrazides were obtained by the estrification of aromatic acid followed by treatment with hydrazine hydrate. The compound (II) was prepared by the exhaustive chlorination of p-chloro isothiocyanate. Structures of all the newly synthesized compounds were confirmed by physical characterization and IR and NMR and Mass spectral analysis.


  1. Hiremath S.P. and Goudar N.N., Ind. J. Chem., 21B, 321-324 (1982)
  2. Dutta M.M., Goswami B.N. and Kataky J.C., J. Ind. Chem. Soc, LXIV 195-978 (1987)
  3. Parekh O., Sharma V. and Batra H., Ind. J. Chem., 37, 797-800 (1998)
  4. Farah M., Pilotti A., Drug Discovery Today, 11(3-4), 165-174 (2006)
  5. Waston B., Tierney J. and Lidstrom P., Drug Discovery Today, 6, 373–380 (2002)
  6. Kidwai M., Kumar P. and Goel Y., Ind. J. Chem., 36B, 175-179 (1997)
  7. Khan K.M., Rani M. and Haider S.M., Lett. Org. Chem., 1, 151 (2004)
  8. Vogel. A.I, Tatchell. A.R, Furnis B.S. and Hannaford A.J, P.W.G. Smith Vogel’s Text Book of Practical Organic Chemistry, 5th Ed. Singapore: Pearson Education, 699 (2004)
  9. Sudeep K. Mandal et al.; International Journal of Pharma Sciences and Research (IJPSR),1(11), 465-472 (2010)
  10. Zamani K., et al., Synthesis of Some New Substituted 1,2,4-Triazole and 1,3,4-Thiadiazole and Their Derivatives Turk J Chem., 27, 119-125 ((2003)
  11. Ilango K., Valentina P., Umarani N. and Kumar T., Indian J Chem., 2009, 1(1), 72-78.
  12. A I. Vogel., A Text Book of Practical Organic Chemistry, Including Qualitative Analysis, Longmans, IIIrd Ed, (1958)
  13. Dyson G.M. and Harington, J. Chem. Soc.,191 (1940)
  14. Kalsi P.S., ‘Spectroscopy of Organic Compounds’, New Age International (P) Ltd., Vth edition (2004)
  15. Kemp W., ‘Organic Spectroscopy’, Palgrave, IIIth edition (2002)