A Study of Transition Metal Complex of Diuretic Drug and study of its Physico-chemical properties as Potential Therapeutic Agent

Abstract

It has been found that biologically active compounds become more effective and bacterio-static upon chelation with metal ions¹. The biological activity of many drugs has been shown to be enhanced on complexing with metal ions, hence promoting their use in Pharmacology⁵. The pharmaceutical action of such ‘drug complexes’ are henceforth studied. In the context of present research work, drugs are used as ligands or chelating agents that contain atoms or groups like N, O, P etc that can attach with metals or metal ions by coordinate linkages to form complexes. . Although a large number of therapeutic agents are known, the literature survey reveals that very little work has been done on the metal complexes of diuretic drugs. The present work deals with the synthesis of metal complexes derived from diuretic drugs and their physio-chemical analysis to find out ligand- metal ratio of these complexes in solution. The complexes of Mn salts are prepared. For the structure elucidation of these complexes “Monovariation method” has been used to ascertain the ligand-metal ratio in the complex. The stability constant of the formed complex was calculated by molar conductance measurement using Modified Job’s method. The analysis has been carried out using conductometry and pHmetry. To confirm metal-ligand ratio, conductometric titrations were carried out at room temperature using analytical grade metal salts. Titrations were carried out with “systronics conductivity-meter” using dip type conductivity cell having cell constant 1 at room temperature. These findings might be useful in the optimization of Amyloride as lead for future development of diuretic drugs for hypertension.