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Microwave assisted synthesis of 3-(4-Ethylbenzyl)-1(4methoxybenzyl)-6-(methylthio)-1, 3, 5-triazine-2, 4 (1H, 3H)-dione derivatives Under solvent free condition with high yields

Author Affiliations

  • 1 Department of Chemistry, K. L. University, Vaddeswaram, Andhra Pradesh, INDIA

Res. J. Recent Sci., Volume 1, Issue (ISC-2011), Pages 105-109,(2012)


A simple and highly efficient procedure has been described for the synthetic derivatives of 3-(4-Ethylbenzyl)-1-(4-methoxybenzyl)-6-(methylthio)-1,3,5-triazine-2,4(1H, 3H)-dione under solvent free condition at microwave power 400 W using domestic microwave. The structures of synthesised compounds are confirmed by using spectral studies.


  1. Coats S.J., Dyatkin A. B., He W. Lisko J., Ralbovsky J. L. and Schultz M. J., Prokineticin 1 receptor antagonists, Patent WO2006104715 (2006)
  2. Coats S.J., Dyatkin A. B., He W. Lisko J., Ralbovsky J. L. and Schultz M.J., Pyrimidindione derivatives as prokineticin 2 receptor antagonists, Patent WO2006104713 (2006)
  3. Coats S. J., Dyatkin A. B., He W., Lisko J. and Miskowski T. A. Ralbovsky J. L. and Schultz M. J. Prokineticin 2 receptor antagonists, Patent WO2007079214 (2007)
  4. Gianfranco B., Ilaria L., Claudio T., Lucia N., Roberta L., Elisa G., Annalisa N., Pietro M. and Sergio V. Chiara De N. and Severo S., Triazine Compounds as Antagonists at Bv8-Prokineticin Receptors, J. Med. Chem., 51, 7635–7639 (2008)
  5. Kaser A., Winklmayr M., Lepperdinger G. and Kreil G. The AVIT protein family, Secreted cysteine-rich vertebrate proteins with diverse functions, EMBO Rep., 4, 469–473 (2003)
  6. LeCouter J., Kowalski J., Foster J., Hass P., Zhang Z., Dillard-Telm L., Frantz G., Angell L., Deguzman L., Keller G., Peale F., Gurney A., Hillan K.J. and Ferrara N., Identification of an angiogenic mitogen selective for endocrine gland endothelium, Nature, 412, 876–884 (2001)
  7. Mollay C., Wechselberger C., Mignogna G., Negri L., Melchiorri P., Barra D. and Kreil G., Bv8, a small protein from frog skin and its homologue from snake venom induce hyperalgesia in rats, Eur. J. Pharmacol., 374, 189–196 (1999)
  8. Negri L., Lattanzi R., Giannini E. and Melchiorri, P., Bv8/Prokineticin proteins and their receptors, Life Sci., 81, 1103–1116 (2007)
  9. Negri L., Lattanzi R., Giannini E., Colucci M., Margheriti F., Melchiorri P., Vellani V., Tian H., De Felice M. and Porreca F., Impaired nociception and inflammatory pain sensation in mice lacking the prokineticin receptor PKR1, focus on interaction between PKR1 and the capsaicin receptor TRPV1 in pain behaviour, J. Neurosci., 26, 6716–6727 (2006)
  10. Negri L., Lattanzi R., Giannini E., Colucci M. A., Mignogna G., Barra D., Grohovaz F., Codazzi F., Kaiser A., Kreil G. and Melchiorri P., Biological activities of Bv8 analogues, Br. J. Pharmacol, 46, 625–632 (2005)
  11. Shojaei F., Wu X., Zhong C., Yu L., Liang X. H., Yao J., Blanchard D., Bais C., Peale F. V., Van Bruggen N., Ho C. Ross J., Tan M., Carano R. A., Meng Y. G. and Ferrara, N. Bv8 regulates myeloid-cell-dependent tumour angiogenesis, Nature, 450, 825– 831 (2007)
  12. Thompson W. J. and Melamed J. Y. Preparation of morpholinecarboxa-mides as prokineticin 2 receptor antagonists, Patent WO2007067511 (2007)