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Synthesis, characterization and de-tert-butylation of 4-N-t-butyl-5-aryl imino-1,2,4 triazolidine-3-thiones into 5-arylimino-1,2,4 triazolidine-3-thiones

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Author Affiliations

  • 1Department of Chemistry, Shri Shivaji Science College, Amravati, MS, INDIA
  • 2 Department of Chemistry, RTM Nagpur University, Nagpur, MS, INDIA

Res. J. Recent Sci., Volume 1, Issue (ISC-2011), Pages 79-84,(2012)

Abstract

Triazole is a five membered heterocyclic ring which is a versatile lead compound for designing potent bioactive agents. The derivatives of triazole nuclei showed diverse biological activities. In the present study, we have synthesised some new 4-N-t-butyl-5-arylimino-1,2,4-triazole-3-thiones (Va-f) from 2-arylimino-5-t-butylimino-1,3,4-thiadiazoles (IVa-f).The later compound were prepared by the condensation of N-aryl thiosemicarbazide (IIa-f) and tert-butyl imino isocyanodichloride in chloroform medium. The synthesized compounds (Va-f) were successfully de-tert butylated into 5-arylimino-1,2,4-triazolidine-3-thione (VIa-f). All the newly synthesized compounds were subjected to physical characterization and spectral analysis by IR and NMR and Mass for structure elucidation.

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