International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN.  International E-Bulletin: Information/News regarding: Academics and Research

Vermifugal Activity of Biofabricated Silver Nanoparticles

    , , , ,

Author Affiliations

  • 1Rajiv Gandhi Chair, Cochin University of Science and Technology, Kochi, Kerala, INDIA
  • 2 School of Environmental Studies, Cochin University of Science and Technology, Kochi, Kerala, INDIA
  • 3 Microbiology, Fermentation and Biotechnology Division, Central Institute of Fisheries Technology, Kochi, Kerala, INDIA
  • 4 Department of Chemical Oceanography, Cochin University of Science and Technology, Kochi, Kerala, INDIA
  • 5 Soil Science Department, Kerala Forest Research Institute, Peechi, Thrissur, Kerala, INDIA

Res. J. Recent Sci., Volume 1, Issue (ISC-2011), Pages 47-51,(2012)

Abstract

Nanotechnology is an area of extensive research in recent years. Applications of noble metals have increased throughout human civilization and noble metal nanoparticles have benefited multiple sectors using their nano-scale applications. The possibility of using plants in the deliberate synthesis of nanoparticles is a recent phenomenon. Helminth infections are among the most common infections in humans, affecting a large population of the World. As per WHO, only few drugs are frequently used in the treatment of these parasite infections. Preliminary investigations were carried out to assess the vermifugal actvity of biological silver nanoparticles in-vitro. Albendazole and piperazine citrate were used as standard reference drugs and normal saline as control. Various concentrations of silver nanoparticles and aqueous extract of Hibiscus rosasinensis were tested as per standard protocols. Silver nanoparticles exhibited significant antihelminthic activity as compared to standard.

References

  1. Lanone S. and Boczkowski J., Biomedical applications and potential health risks of nanomaterials: molecular mechanisms, Curr Mol Med., 6, 651–63 (2006)
  2. Ball P., Natural strategies for the molecular engineer, Nanotechnology, 13, 15-28 (2002)
  3. Wang X., Zhuang J., Peng Q. and Li. Y., A general strategy for nanocrystal synthesis, Nature, 437, 121–124 (2005)
  4. Pillai Raji K., Bishwajeet Singh., Deep Punj., Kailasnath M and Chandramohanakumar N., Green synthesis and characterization of silver nanoparticles using the leaf and flower extract of Hibiscus rosasinensis, Proceedings of International Conference on Nanostructured Materials, France, p 306 (2010)
  5. Williams D.A. and Lemke T.L., Parasitic infection- Helminthes In, Foye’s Principal of Medicinal Chemistry, 5th edition, New York: Lippincott William and Wilkins. (2002)
  6. WHO, Informal Consultation on Intestinal Helminth Infections, Geneva, 9–12 July 1990, Geneva, World Health Organization document WHO/CDS/IPI/90.1, (1990)
  7. Coles, E. H., Veterinary Clinical Pathology, 4th Ed., W. B. Saunders Company, USA (1986)
  8. Soulsby E.J.L., Text book of: helminths, arthropods, and protozoa of domesticated animals, 7th edn. The English Language Book Society and Bailliere Tindall, Loncon (1986)
  9. Albonico M., A randomised controlled trial comparing mebendazole 500mg and mebendazole 400 mg against Ascaris, Trichuris and the hookworms, Transactions of the Royal Society of Tropical Medicine and Hygiene, 88, 585–589 (1994)
  10. Martin, R. J., Mode of Action of Anthelmintic Drugs, Vet. J, 154, 11- 34 (1997)
  11. Coles, G. C., Borgsteede F. H. M., Geerts, T. R. and Tylor M. A., World Association for the Advancement of Veterinary Parasitology methods for the detection of anthelmintic resistance in nematodes of veterinary importance. Vet. Parasitol., 44, 35-44 (1992)
  12. Kwa M.S., Veenstra, J.G. and Roos M. H., Benzimidazole resistance in Haemonchus contortus is correlated with a conserved mutation at amino acid 200 in beta‐tubulin isotype, Mol. Biochem Parasitol., 63, 299–303 (1994)
  13. Harder A. and Himmelstjerna V.S.G., Cyclooctadepsipeptides, a new class of anthelmintically active compounds, Parasitol Res., 88, 481–488 (2002)
  14. Mamun, M. I. R.., Nahar, N. and Azad Khan., Diabetic Research And Clinical Practice, 35, 163-170, (2001)
  15. Vigar Z., Atlas of Medical Parasitology, 2nd edition. Singapore, P.G. Publication House, 216-217 (1984)
  16. Ajaiyeoba E.O., Onocha P.A. and Olarenwaju O.T., In vitro anthelmintic properties of Buchholzia oriaceae and Gynandropsis gynandra extract, Pharm. Biol., 39, 217-20, (2001)
  17. Martin RJ., γ-Aminobutyric acid and piperazine activated single channel current from Ascaris suum body muscle, Br. J. Pharmacol., 84, 445-461 (1985)
  18. Ruffini Castiglione M. and Cremonini R., Nanoparticles and higher plants, Caryologia., 62:161–165, (2009)
  19. Nel A.E., Mdler L., Velegol D., Xia T., Hoek E., Somasundaran P., Klaessig F., Castranova V. and Thompson M., Understanding the biophysicochemical interactions at the nano–bio interface. Nat. Mater., 8:543–55, (2009)
  20. Xia T, Kovochich M, Brant J, Hotze M, Sempf J, Oberley T, Sioutas C, Yeh J.I, Wiesner M.R. and Nel A.E., Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Lett., 6, 1794–1807 (2006)