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The Effects of Induced Hyperthyroidism on Plasma FSH and LH Concentrations in Female of Wistar Rats

Author Affiliations

  • 1 Idris O.F. and Sabahelkhier M.K.Department of Biochemistry, Faculty of Medicine and Health Sciences, University of Dongola, SUDAN
  • 2 Department of Biochemistry and Molecular Biology, Faculty of Science and technology EL-Neelain University, SUDAN

Res. J. Recent Sci., Volume 1, Issue (6), Pages 55-57, June,2 (2012)


Thyroxine and triodothyroine are essential for the normal growth, development and functions for normal organs. These hormones regulate the basal metabolic rate (BMR) of all cells and play a critical role in the development of several organ systems such as reproduction system. Our objectives are to investigate the effects of experimental induced hyperthyroidism on plasma FSH and LHconcentrations in female Wistar rats and answer specific question what was worse to have excess thyroid hormones. The experimental study was located at the University of Kwa-Zulu Natal (UKZN), Faculty of Science and Agriculture, School of Biochemistry, Genetics and Microbiology, Westville Campus South Africa, from October 2009 - May 2010. Twenty four adults female Wistar rats divided into two main groups, twelve rats in each were used. Thyroxine was administered orally. The dose was 100 μg/ kg body weights for three weeks daily at 9:00 am; Euthyroid rats received three ml of deionizer water. The results of thyroid hormones concentration (TSH, T3 and T4) and gonadtrophins (FSH and LH) were determined by using enzyme immunoassay kits from TOSOH, Corporation Japan. By Hitachi 906 analyzer. Rats body weight and food, water consumption were record every third day of experimental. The results of rats body weight showed significant decreased (P ≤ o.o5) in hyperthyroid rats compared to control group. Thyroid hormones showed significant (P ≤ o.o5) increased in hyperthyroid, but FSH and LH showed conflict results.


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