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Hypervitaminosis - A causes Degenerative changes in Thyroid of Mouse

Author Affiliations

  • 1 Hi-tech laboratory of Molecular developmental Biology, Department of Zoology, M.D.S. University, Ajmer, Rajasthan, INDIA

Res. J. Recent Sci., Volume 1, Issue (3), Pages 26-30, March,2 (2012)


Retinol Palmitate (RP) is known for its effects on differentiation and morphogenesis during vertebrate development, as it is important for reproduction development and growth, hyper and hypo-vitaminosis- A both provoke epithelial pathologies in animal and human being. So a critical value of RP is required in vivo for the maintenance of normal architecture and function of many body tissues. Thyroid gland is unique among vertebrate endocrine glands is that it stores its secretary products i.e. thyroid hormone. The thyroid influence reproduction, growth and differentiation. The group of adult mouse was treated 4 IU/ day concentration of RP by intubations for 7 days. This constituted the treated group. A similar number of mice were considered as controlled group, and were not given any RP treatment. The animal were observed for their growth, behavior and weight, during the period of treatment. On 8th day of the experiment thyrodactomy was done to both treated as well as controlled mice. The thyroid tissues taken were processed and sectioned for both light as well as electron microscopy. Following observation was made. In treated case hypertrophy of thyroid gland was seen. The thyroid follicle of the treated mice showed disorganization of their cells and the cells changed their cuboidal shape to an irregular shape. Ultra structure studies showed an irregular shaped nucleus. The studies concluded that RP treatment results in a reduced activity of thyroid follicles i.e. reduced synthesis of thyroxin.


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