6th International Virtual Congress (IVC-2019) And Workshop.  International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN.  International E-Bulletin: Information/News regarding: Academics and Research

OncmiRs: Small Noncoding RNA with Multifaceted Role in Cancer

Author Affiliations

  • 1 Interdisciplinary Research Centre, Department of Biotechnology, Malankara Catholic College, Mariagiri, Kaliakkavilai, TN, INDIA

Res. J. Recent Sci., Volume 1, Issue (11), Pages 70-76, November,2 (2012)


Several advancements in cancer research occur till date and the involvement of miRNAs in cancer threw new hope to cancer therapy. OncomiRs are miRNAs which plays significant role in cancer. It serves as a double edged sword in cancer because up- regulation and down- regulation of miRNAs are observed in cancerous cells and hence acts as oncogenes and tumor suppressors respectively. Since, cancer is a disease affecting multiple cell types and with different stages, treatment of it remains as a biggest challenge. miRNA turns to be a promising therapeutic tool in cancer due to its regulatory role. This review briefs the multiple role of miRNA in cancer with special emphasis on tumor microenvironment, cell proliferation, angiogenesis, metastasis and apoptosis. Moreover the tumor suppressor and oncogenenic role of miRNAs are also discussed.


  1. Bartel D.P., MicroRNAs: Genomics, biogenesis, mechanism and function, Cell, 116, 281-97 (2004)
  2. Lee C., Rosalind Feinbaum, L. Rhonda Ambros, Victor, The C. elegans Heterochronic Gene lin-4 Encodes Small RNAs with Anitsense Complementary to lin-14, Cell, 75,843-854 (1993)
  3. Lee R.C. and V. Ambros, An extensive class of small RNAs in Caenorhabditis elegans,Science, 294, 862-864 (2001)
  4. Pasquinelli A.E., Reinhart B.J., Slack F., Martindale M.Q. and Kuroda M.I. et al., Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA, Nature, 408, 86-89 (2000)
  5. Lu J., Getz G., Miska E.A., Alvarez-Saavedra E. and Lamb J., et al., Microrna expression profiles classify human cancers, Nature, 435, 834-8 (2005)
  6. Calin G.A., Sevignani C. and Dumitru C., et al., Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers, PNAS, 101, 2999-3004 (2004)
  7. Yao Q., Xu H., Zhang Q.Q., Zhou H. and Qu L.H., MicroRNA-21 promotes cell proliferation and down-regulates the expression of programmed cell death 4(PDCD4) in HeLa cervical carcinoma cells, Biochem Biophys Res Commun,388(3), 539-42 (2009)
  8. Feng S., Cong S., Zhang X., Bao X., Wang W., Li H., Wang Z., Wang G., Xu J., Du B., Qu D., Xiong W., Yin M., Ren X., Wang F., He J. and Zhang B., MicroRNA-192 targeting retinoblastoma 1 inhibits cell proliferation and induces cell apoptosis in lung cancer cells, Nucleic Acids Res., 39(15), 6669-78 (2011)
  9. Yan D., Zhou X., Chen X., Hu D.N., Dong X.D., Wang J., Lu F., Tu L. and Qu J., MicroRNA-34a inhibits uveal melanoma cell proliferation and migration through downregulation of c-Met, Invest Ophthalmol Vis Sci, 50(4), 1559-65 (2009)
  10. Huang Z., Huang S., Wang Q., Liang L., Ni S., Wang L., Sheng W., He X. and Du X., MicroRNA-95 promotes cell proliferation and targets sorting Nexin 1 in human colorectal carcinoma, Cancer Res., 71(7), 2582-9 (2011)
  11. Musumeci M., Coppola V., Addario A., Patrizii M., Maugeri-Saccà M., Memeo L., Colarossi C., Francescangeli F., Biffoni M., Collura D., Giacobbe A., D'Urso L., Falchi M., Venneri M.A., Muto G., De Maria R. and Bonci D., Control of tumor and microenvironment cross-talk by miR-15a and miR-16 in prostate cancer, Oncogene,30(41), 4231-42 (2011)
  12. Mbeunkui F. and Johann D.J., Jr. Cancer and the tumor microenvironment: a review of an essential relationship, Cancer Chemother Pharmacol., 63(4), 571–582 (2009)
  13. Suarez Y., Fernandez-Hernando C., Yu J., Gerber S.A., Harrison K.D., Pober J.S., Iruela-Arispe M.L., Merkenschlager M. and Sessa W.C., Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis, Proc Natl Acad Sci U S A,105, 14082–14087 (2008)
  14. le Sage C., Nagel R., Egan D.A., Schrier M., Mesman E., Mangiola A., Anile C., Maira G., Mercatelli N., Ciafrè S.A., Farace M.G. and Agami R., Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation, EMBO J., 26(15), 3699-708 (2007)
  15. Martin M.M., Lee E.J., Buckenberger J.A., Schmittgen T.D. and Elton T.S., MicroRNA-155 regulates human angiotensin II type 1 receptor expression in fibroblasts, J Biol Chem., 281(27), 18277-84 (2006)
  16. Bonauer A., Carmona G., Iwasaki M., Mione M., Koyanagi M., Fischer A., Burchfield J., Fox H., Doebele C., Ohtani K., Chavakis E., Potente M., Tjwa M., Urbich C., Zeiher A.M. and Dimmeler S., MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice, Science,324(5935), 1710-3 (2009)
  17. Nikolic I., Plate K.H. and Schmidt M.H., EGFL7 meets miRNA-126: an angiogenesis alliance, J Angiogenes Res., 2(1), 9 (2010)
  18. Bhaumik D., Scott G.K., Schokrpur S., Patil C.K., Campisi J. and Benz C.C., Expression of microRNA-146 suppresses NF-nB activity with reduction of metastatic potential in breast cancer cells, Oncogene,27, 5643–7 (2008)
  19. Ma L., Teruya-Feldstein J. and Weinberg R.A., Tumour invasion and metastasis initiated by microRNA-10b in breast cancer, Nature, 449, 682–8 (2007)
  20. Huang Q., Gumireddy K. and Schrier M., et al. The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis, Nat Cell Biol, 10, 202–10 (2008)
  21. Xu P., Vernooy S.Y., Guo M. and Hay B.A., The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism, Curr Biol,13, 790–795 (2003)
  22. Chan J.A., Krichevsky A.M. and Kosik K.S., MicroRNA21 is an antiapoptotic factor in human glioblastoma cells, Cancer Res.,65, 6029-6033 (2005)
  23. Calin G.A., C.D. Dumitru M. Shimizu R. Bichi and S. Zupo et al., Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukaemia, Proc. Natl. Acad. Sci. USA., 99,15524-15529 (2002)
  24. Cimmino A., Calin G.A., Fabbri M. and Ferracin M. et al., MiR15 and miR-16 induce apoptosis by targeting BCL2. PNAS, 102, 13944-13949 (2005)
  25. Volinia S., Calin G.A. and Liu C.G. et al., A microRNA expression signature of human solid tumors defines cancer gene targets, Proc. Natl Acad. Sci. USA., 103, 2257-2261 (2006)
  26. Ciafre S.A., Galardi S., Mangiola A., Ferracin M. and Liu C.G. et al., Extensive modulation of a set of microRNAs in primary glioblastoma, Biochem. Biophys. Res. Commun., 334, 1351-1358 (2005)
  27. Esquela-Kerscher A., Trang P., Cheng A., Ford L. and Weidhaas J. et al., The let-7 microRNA reduces tumor growth in mouse models of lung cancer, Cell Cyc., 7, 759-64 (2008)
  28. Bhattacharya R., Nicoloso M., Arvizo R., Wang E. and Cortez A. et al., Mir-15a and MiR-16 control Bmi-1 expression in Ovarian Cancer, Cancer Res., 69, 9090-9095 (2009)
  29. Tanic M., Yanowsky K., Rodriguez-Antona C., Andrés R., Márquez-Rodas I., Osorio A., Benitez J. and Martinez-Delgado B., Deregulated miRNAs in Hereditary BreastCancer Revealed a Role for miR-30c in Regulating KRAS Oncogene, PLoS One. 7(6), e38847 (2012)
  30. Noguchi S., Mori T., Otsuka Y., Yamada N., Yasui Y., Iwasaki J., Kumazaki M., Maruo K. and Akao Y., Antioncogenic microRNA-203 induces senescence by targeting E2F3 protein in human melanoma cells, J Biol Chem., 287(15), 11769-77 (2012)
  31. Tao J., Wu D., Li P., Xu B., Lu Q., Zhang W., microRNA-18a, a member of the oncogenic miR-17-92 cluster, targets Dicer and suppresses cell proliferation in bladder cancer T24 cells, Mol Med Report,5(1), 167-72 (2012)
  32. Choong C. and Say Y., Knockdown of -Synuclein Enhances Susceptibility to Staurosporine Induced Apoptosis in Human Melanoma SK-MEL28 Cells, Journal of Biological Sciences, 11, 135-145 (2011)
  33. He L., Thomson J.M., Hemann M.T., Hernando-Monge E. and Mu D. et al., A microRNA polycistron as a potential human oncogene, Nature, 435, 828-833 (2005)
  34. Virginie O., Bennett M.J., Walker J.C. and Ma C. et al., Mir-19 is a key oncogenic component of mir-17-92, Genes Dev.,23, 2839-2849 (2009)
  35. Iorio M.V., Ferracin M., Liu C.G., Veronese A. and Spizzo R. et al., MicroRNA gene expression deregulation in human breast cancer, Cancer Res., 65, 7065-7070 (2005)
  36. Zhu S., Si M.L., Wu H. and Mo Y.Y., MicroRNA-21Targets the tumor suppressor gene Tropomyosin 1 (TPM1), J.Biol.Chem., 282, 14328-14336 (2007)
  37. Brueckner B., Stresemann C., Kuner R., Mund C. and Musch T. et al., The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function, Cancer Res., 67, 1419-1423 (2007)
  38. Wang Y., Rathinam R., Walch A. and Alahari S.K., ST14 (suppression of tumorigenicity 14) gene is a Target for miR-27b and the inhibitory effect of ST14 on cell growth is independent of miR-27b regulation, J. Biol. Chem., 284,23094-23106 (2009)
  39. Streicher K.L., Zhu W., Lehmann K.P., Georgantas R.W., Morehouse C.A., Brohawn P., Carrasco R.A., Xiao Z., Tice D.A., Higgs B.W., Richman L., Jallal B., Ranade K. and Yao Y.A, Novel oncogenic role for the miRNA-506514 cluster in initiating melanocyte transformation and promoting melanoma growth, Oncogene, 31(12),1558-70 (2012)
  40. Zhong X.Y., Yu J.H., Zhang W.G., Wang Z.D., Dong Q., Tai S., Cui Y.F. and Li H., MicroRNA-421 functions as an oncogenic miRNA in biliary tract cancer through down-regulating farnesoid X receptor expression, Gene., 493(1), 44-51 (2012)