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Behaviours of liver and kidney function markers in diabetic rats treated with Calotropis procera leaf aqueous extract

Author Affiliations

  • 1Department of Biochemistry & Molecular Biology, Nasarawa State University, Keffi - Nasarawa State, Nigeria
  • 2Department of Biochemistry & Molecular Biology, Nasarawa State University, Keffi - Nasarawa State, Nigeria

Res.J.chem.sci., Volume 9, Issue (4), Pages 14-19, October,18 (2019)


Long-term high blood glucose causes diabetes mellitus; this metabolic disorder is accompanied by both short – and long terms complications. In the present study, behaviours of liver and kidney function markers in diabetic rats treated with different doses of Calotropis procera leaf aqueous extract were studied. At p>0.05, the blood glucose, hepatic GOT, GPT, albumin, total bilirubin, GOT/GPT ratio, serum urea and creatinine were significantly elevated in diabetic groups (B, C, D, E and F), while hepatic glycogen was significantly reduced with induction of alloxan. Treatment with the extract at different doses of administration (25, 50 100mg/kg b.w.) particularly higher doses restored the markers back to their normal levels when compared to mean values of non-diabetic group (A). Mean values of markers in group administered 100mg/kg b.w. dose of extract, non-diabetic and metformin treated groups (A and B) were in the same range. In the present study, it can be deduced that aqueous extract of Calotropis procera leaf at 100 mg/kg b.w dose showed significant potency in amelioration of alloxan disturbances on hepatic and renal function markers.


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