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Role of molecularly imprinted polymers for selective determination of antiepileptic drug-carbamazepine: a short review

Author Affiliations

  • 1Department of Chemistry, Punjabi University, Patiala-147002, Punjab, India
  • 2Department of Chemistry, Punjabi University, Patiala-147002, Punjab, India
  • 3Department of Chemistry, Punjabi University, Patiala-147002, Punjab, India
  • 4Department of Chemistry, Punjabi University, Patiala-147002, Punjab, India

Res.J.chem.sci., Volume 7, Issue (6), Pages 26-30, June,18 (2017)


Epilepsy is a neurological condition marked by frequent and unprovoked seizures. Antiepileptic drugs (AEDs) play a prominent role for treatment of epilepsy by achieving good control with medications. But, in past few decades, lot of studies shows that with the continuous release of these drugs into the environment, equally contributes them in a category of persistent organic pollutants (POP). Carbamazepine (CBZ), an antiepileptic drug is over a great extent used to treat epilepsy and bipolar disorder. This is also included in the POP category because of its profound use and possible ecotoxicology. Analytical methods should have the sensitivity for contamination detection and quantification, but in case of complex matrices or real matrices the direct application of the analytical methods can be rarely achieved. Thus, sensitive and selective analytical methods are required. The increasing use of molecular imprinted polymers during recent years in pharmaceutical analysis in complex matrices is because these materials seem to be particularly desirable for applications where analyte sensitivity and selectivity is essential. They show preferred affinity to a particular template molecule as compared to other molecules present in complex matrices, and this property of selectivity is the main driving force for such diverse application of this techniques. Such techniques have been more and more employed in a wide range of applications such as sample pretreatment, chromatography, catalysts, drug delivery, sensors, purification, bio-analytical areas etc.


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