International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN.  International E-Bulletin: Information/News regarding: Academics and Research

Synthesis and Characterization of Macrocycles Derieved from Bis-Triazole

Author Affiliations

  • 1Department of Chemistry, Sant Gadge Baba Amravati University, Amravati-444 602, (MS) India
  • 2Department of Chemistry, Sant Gadge Baba Amravati University, Amravati-444 602, (MS) India

Res.J.chem.sci., Volume 6, Issue (8), Pages 10-14, August,18 (2016)


The new macrocyclic Schiff bases were obtained by condensing the 5,5\'-(butane-1,4-diyl)bis(4-amino-4H-1,2,4-triazole-3-thiol) with the corresponding dialdehyde. The dialdehydes needed for the macrocycles were synthesized by using substituted hydroxyl aldehyde, which was converted into its potassium salt and treated with appropriate dibromoalkane to afford the corresponding dialdehyde. All the synthesized compounds were characterized by IR,1H-NMR, mass and some of the representative by 13C-NMR spectra.


  1. Rednic M.I., Hadade N.D. and Grosu E.B.I. (2015)., Macrocycles embedding phenothiazine or similar nitrogen and/or sulphur containing heterocycles., J. Incl. Phenom. Macrocycle Chem., 81(3), 263-293.
  2. Khalaji A.D., Ghoran S.H., Rohlicek J. and Dusek M. (2015)., Characterization and crystal structure of a 17-membered macrocyclic Schiff base compound MeO-sal-pn-bn., J. struct chem.,56(2), 259-265.
  3. Foroughifar N., Mobinikhaledi A. and Ebrahimi S. (2009)., Synthesis of a Novel Class of Azacrown Macrocycles and Lariat Crown Ethers Containing Two 1,2,4-Triazole Rings as Subunits., Synthesis, 15, 2557-2560.
  4. Potts K.T. (1961)., The Chemistry of 1,2,4-Triazoles., Chem. Rev., 61(2), 87-127.
  5. Agalave S.G., Maujan S.R. and Pore V.S. (2011)., Click Chemistry: 1,2,3-triazole as pharmacophore., J.Chem. Asian., 6(10), 2696-2718.
  6. Kane J.M., Baron B.M., Dudley M.W., Sorensen S.M., Staeger M.A. and Miller F.P. (1990)., 2,4-Dihydro-3H-1,2,4-triazol-3-ones as anticonvulsant agents., J.Med.Chem., 33(10), 2772-2777.
  7. Noblia P., Vieites M., Parajon-Costa B.S., Baran E.J., Cerecetto H., Draper P., Gonzalez M., Piro O.E., Castellano E.E., Azqueta A., Cerain A.L. and Gambino A.D. (2005)., Vanadium (V) complexes with salicylaldehyde semicarbazone derivatives bearing in vitro anti-tumor activity toward kidney tumor cells (TK-10): crystal structure of [VVO2(5-bromosalicylaldehyde semicarbazone)], J. Inorg. Biochem., 99(2), 443-451.
  8. Zitouni G.T., Kaplancikli Z.A., Erol K., Kilic F.S. (1999)., Synthesis and analgesic activity of some triazoles and triazolothiadiazines., II Farmaco, 54(4), 218-223.
  9. Khalil N.S.A.M. (2010)., Efficient synthesis of novel 1,2,4-triazole fused acyclic and 21-28 membered macrocyclic and/or lariat macrocyclic oxaazathia crown compounds with potential antimicrobial activity.,, 45(11), 5265-5277.
  10. Abbas A. A. (2004)., Synthesis of novel lariat azathia crown macrocycles containing two triazole rings and bis crown macrocycles containing four triazole rings., Tetrahedron, 60(7), 1541-1548.
  11. Xu P.F., San X-W., Zang L.M. and Zang Z.Y. (1999)., A Facile Synthesis of Bis(4-amino-5-mercapto-1,2,4-triazol-3-yl)alkanes and Bis(5-mercapto-4H-1,2,4-triazol-3-yl)alkanes., J. chem. Research.,(2), 170-171.
  12. Pellisard D. and Luis R. (1972)., Ligands macrocycliques pentadendates., Tetrahedron Lett., 13(45), 4589-4593.
  13. Overman L.E. (1972)., Dehydrogenase Enzyme Models. Approximation of an Alcohol and a Pyridinium Ring.,, 37, 4214-4218.