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Synthesis of (-) Baclofen as a Neurotransmitter Inhibitor

Author Affiliations

  • 1Department of Chemistry, MNG Science College Babhulgaon-445101, India
  • 2Department of Chemistry, Savitribai Phule University of Pune-411007, India
  • 3Department of Chemistry, MNG Science College Babhulgaon-445101, India
  • 4Department of Chemistry, Savitribai Phule University of Pune-411007, India

Res.J.chem.sci., Volume 6, Issue (8), Pages 6-9, August,18 (2016)

Abstract

Here, we reports enantioselective Michael additions reaction of diethyl malonate with substituted styrene. The yield ranges from 80-65 % having enantioselectivity 80-95%. The present strategy useful for the synthesis (-)-Baclofen. Starting from commercially available 4-chlorobenzaldehyde.

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