International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN.  International E-Bulletin: Information/News regarding: Academics and Research

Synthesis, Characterisation and Screening of newly synthesised analogues of Imidazolo-Thiazoles and their Impact on growth of Oyster mushroom spp. (Pleurotus sajor-caju)

Author Affiliations

  • 1Department of Chemistry, S.S.S.K.R. Innani Mahavidyala, Karanja (Lad), Dist. Washim, MS, India
  • 2Department of Chemistry, Vidya Bharati Mahavidyalaya, C.K.Naidu Road, Camp, Amravati-444602, MS, India

Res.J.chem.sci., Volume 6, Issue (5), Pages 17-21, May,18 (2016)

Abstract

The majority of farmers and mushroom growers in tropical region of country (Central India) has been experimenting with Oyster mushroom cultivation and are very worried about the very high temperature and susceptibility of mushroom crops towards the pathogens responsible for common crop diseases. This is the main constraint in the large scale cultivation of edible mushrooms like Oysters in this part of the country. As a consequence, ultimate yield of Oyster mushroom in Central India is adversely affected. Whenever, the crops fall prey to diseases, farmers try to control them by spraying some fungicides on them but in many cases they do not succeed. Basic understanding about the disease is a prior strategy to manage them. To safeguard the crop by various preventive and controlling measures which were elaborated by several workers with some basic aspects based on their research activity. Literature survey reveals that, the utility of imidazole substituted azoles in the fields of agricultural science and medicinal chemistry is ever-increasing. Owing to their importance in the field of agriculture as plant protecting and growth regulating agents, we thought it worthwhile to study the efficacy of newly synthesised heterocycles viz. 2-phenylamino-4-benzoyl-5-(2-hydroxy-5-chlorophenyl)-1,3-thiazole, 2-N-phenyl-N-[(2-hydroxy-5-chloro-phenyl)ethanonylamino]-4-benzoyl-5-(2-hydroxy-5-chlorophenyl)-1,3-thiazole, 2-[2-phenylthio-4-(2-hydroxy-5-chlorophenyl)imidazolo]-4-benzoyl-5-(2-hydroxy-5-chlorophenyl)-1,3-thiazole and 2-[2-phenylthio-4-(2-acetyloxy-5-chloro-phenyl)imidazolo]-4-benzoyl-5-(2-acetyloxy-5-chlorophenyl)-1,3-thiazole in the light of their significance towards growth promoting and disease controlling impact on Oyster mushroom crop. The results obtained in the present study are very encouraging.

References

  1. Kumar A., Singh I., Kaur H., Kumar S., Lata S. and Kumar A. (2010)., Synthesis and antibacterial activity of 3-chloro-4- (substitutedphenyl) azetidinonyl / thiazolidinonyl -4- (3-acetanilido) oxa/thiazoles., IJPSR, 1(2), 148-168.
  2. Ali A.R., El-Bendary E.R., Ghaly M.A. and Shehata I.A. (2014)., Synthesis, in vitro anticancer evaluation and in silico studies of novel imidazo [2,1-b]thiazole derivatives bearing pyrazole moieties., European Journal of Medicinal Chemistry, 75, 492-500.
  3. Doss M.L. and Lalitha K.G. (2011)., Synthesis and antimicrobial screening of novel mono and tri schiff bases of thiazole derivatives., Sci. Revs. Chem. Commun., 1(1), 49-57.
  4. Govindaraju M., Kumar G.V., Pavithra G., Nayaka M.A.H., Mylarappa B.N. and Kumar K.A. (2012)., Evaluation of new tetra substituted pyrazolines for their antimicrobial and antioxidant activity; Structure-activity relationship., IOSRJPBS, 2(6), 30-34.
  5. Gupta V. and Kant V. (2013)., A review on biological activity of imidazole and thiazole moieties and their derivatives., Science International, 1(7), 253-260. DOI: 10.17311/sciintl.2013.253.260.
  6. Al-Rashood K.A. and Abdel-Aziz H.A. (2010)., Thiazolo[3,2-a]benzimidazoles: Synthetic strategies, chemical transformations and Biological activities., Molecules, 15, 3775-3815.
  7. Bhosale S.V., Shitre G.V., Bhosale R.S., Karhale D.S., Sujitha P., Ku-mar C.G. and Ramakrishna K.V.S. (2014)., Synthesis and Biological Evaluation of Novel α-Aminophosphonate Derivatives Possessing Thiazole-Piperidine Skeleton as Cytotoxic Agents., Chemistry and Biology Interface, 4(1), 48-57.
  8. Pattan S.R., Hullolikar R.L., Dighe N.S., Ingalagi B.N., Hole M.B., Gaware V.M. and Chavan P.A. (2009)., Synthesis and evaluation of some new phenyl thiazole derivatives for their anti-inflammatory activities., J. Pharm. Sci. & Res., 1(4), 96-102.
  9. Sreedevi M., Prasad A.R. and Spoorthy Y.N. (2013)., Ravindranath L.K., Synthesis and antimicrobial evaluation of certain novel thiazoles., Advanced Pharmaceutical Bulletin, 3(1), 227-230.
  10. Kalluraya B., Frank P. and Adhikari A. (2011)., Synthesis and pharmacological studies on some novel imidazo thiazoles., Der Pharma Chemica, 3(2), 277-282.
  11. Jayachandran E, Shameer H, Nageswara R.R., Kumar V.M. and Sreenivasa G.M., (2013)., Synthesis, characterization and anti-inflammatory activity of novel N-substituted-5-oxa-imidazole., IJRPB, 1(1), 50-53.