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Efficient Ultrasound Synthesis, Spectral studies of 1-(2-hydroxyphenyl)-3-(4-nitrophenyl) propane-1, 3-dione with metal complexes as antibacterial and antifungal agents

Author Affiliations

  • 1Department of Chemistry, Rayat Shikshan Sanstha’s Annasaheb Awate College, Manchar (M.S.), India 410 503
  • 2Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad (M.S.) India 431 004
  • 3Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad (M.S.) India 431 004
  • 4Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad (M.S.) India 431 004

Res.J.chem.sci., Volume 6, Issue (11), Pages 44-47, November,18 (2016)

Abstract

The newly synthesized 1-(2-hydroxy phenyl)-3-(4-nitrophenyl) propane-1, 3-dione with their transition metal (II) complexes 5(a-e) under ultrasound irradiation methods at low temperature were characterized by elemental analysis, FTIR, 1H-NMR spectrum, Mass, and Electronic spectroscopy. The ratio of the metal (II) complexes was found to be 1:2 (metal: ligand). The analytical data suggested that octahedral geometry for the all complexes. The synthesized ligand and their metal complexes 5(a-e) were screened for antimicrobial activity against S. aureus, B. Subtilis and A. Niger and F. Oxysporum using streptomycin as a references drugs.

References

  1. Bray D.J., Clegg J.K., Lindoy L.F. and Schilter D. (2007)., Synthetic, structural, electrochemical and solvent extraction studies of neutral trinuclear Co(II), Ni(II), Cu(II) and Zn(II) metallocycles and tetrahedral tetranuclear Fe(III) species incorporating 1,4-aryl-linked bis-b-diketonato ligands., Adv. Inorg. Chem., (59), 1-37.
  2. Aromi G., Gamez P. and Reedik J. (2008)., Poly beta-diketones: Prime ligands to generate supramolecular metalloclusters., Coord. Chem. Rev., (252), 964–989
  3. Alessandro Vigato P., Valentina Peruzzo and Sergio Tamburini (2009)., The evolution of β-diketone ligands and related complexes., Coord. Chem. Rev., (253), 1099–1201,
  4. Aho P., Backstrom R., Honkanen E., Linden I., Nissien E. and Pohto P. (1994)., nr 163044 BI., PL Patent.
  5. Acton N., Brossi A., Newton D.L. and Sporn M.B. (1980)., Potential prophylactic antitumor activity of retinylidene 1,3-diketones., J. Med. Chem., (23), 805-809.
  6. Dalal A., Kamboj R.C., Kumar D., Sharma M.K. and Selvarajan N. (2015)., Crystal structure of (Z)-3-[5-chloro-2-(prop-2-ynyloxy)phenyl]-3-hy-droxy-1-[4-(trifluoromet hyl)phenyl]prop-2-en-1-one., Acta Cryst., E71, 556-557.
  7. Nishiyama T., Shiotsu S. and Tsujita H. (2002)., Antioxidative activity and active site of 1,3-indandiones with the β-diketone moiety., Polym. Degrade. Stab, (76), 435-439.
  8. Crouse G.D., McGowan M.J. and Boisvenue R.J. (1989)., Polyfluoro 1,3-diketones as systemic insecticides., J. Med. Chem., (32), 2148-2151
  9. Hemmila I.A. (1991)., Applications of Fluorescence in Immunoassay., Wiley, New York, ISBN: 0-85186-225-x
  10. Sabbatini N., Guardigli M. and Lehn J.M. (1993)., The chemistry of Metal-Organic Framework., Coord. Chem., (123), 201–228
  11. Zhimin Chen, Wu. Yiqun, Fuxin. Huang, Gu. Donghong and Fuxi. Gan, (2007)., Spectroscopic and thermal properties of short wavelength metal (II) complexes containing alpha-isoxazolylazo-beta-diketones as coligands., Spectrochim. Acta Part A., (66), 1024–102.
  12. Karvembu R. and Natarajan K. (2002)., Synthesis and spectral studies of binuclear ruthenium (II) carbonyl complexes containing bis (β-diketone) and their applications., Polyhedron., (21), 219–223
  13. Huaqiang Zeng, Jianming Xie and Schultz P.G. (2006)., Genetic introduction of a diketone-containing amino acid into proteins, Bioinorg. Med. Chem. Lett., (16), 5356-5359.
  14. Ameerunisha Begum M.S., Sounik Saha, Akhtar Hussiain and Chakravarty A.R. (2009)., Synthesis, Crystal Structure of DNA cleavage of Copper (II) Complexes., Indian J.Chem, (48A), 9-14,
  15. Raman N., Mitu L., Sakthivel A. and Pandi M.S.S. (2009)., Studies on DNA cleavage and antimicrobial screening of transition metal complexes of 4-aminoantipyrine derivatives of N2O2 type., J. Iran. Chem. Soc., (6), 738–748.
  16. Bennett I., Broom N.J.P., Cassels R., Elder J.S., Masson N.D. and O’Hanlon P.J. (1999)., Synthesis and antibacterial properties of beta-diketone acrylate bioisosteres of pseudomonic acid., Med. Chem. Lett., (9), 1847-1852
  17. Kumari Neetu, Yadav Pradeep and Joshi Yogesh C. (1978)., Synthesis of Some Novel β-Diketones and β-Ketoesters of 4-Methyl Sulphonyl Benzoyl Methylene Bromide., Chem. Sci Trans., 2(1), 81-84.
  18. Korde N.S., Gaikwad S.T., Khade B.C. and Rajbhoj A.S. (2013)., Efficient Ultrasound Synthesis, Characterizations and Antimicrobial Screening of Novel Cyclic ß-Diketones., Chem. Sci. Trans., (2),
  19. Korde N.S., Gaikwad S.T., Korde S.S. and Rajbhoj A.S. (2013)., Ultrasound synthesis, characterization and thermal study of some ransition metal complexes of β-diketone ligand., J. of Rec. Tech. and Engin. (2), 4.
  20. Kumar U. and Chandra S. (2011)., Mn(II), Co(II), Ni(II), & Cu(II) Complexes of Nitrogen and Sulphur Donar ligands., J. Saudi Chem. Soc. (15), 187–193
  21. Munde A.S., Jagdale A.N., Jadhav S.M. and Chondhekar T.K. (1979)., Synthesis, characterization and thermal study of some transition metal complexes of an asymmetrical tetradentate Schiff base ligand., Journal of Serbian Chemical Society, 75(3), 349-359.
  22. Sing D.P., Kumar R., Malik V. and Tagi P. (2007)., Template synthesis and characterization of biologically active transition metal complexes comprising 14-membered tetraazamacrocyclic ligand., Journal of Serbian Chemical Society, 75(2), 217-228.
  23. Chandra S., Tyagi M. and Agrawal S. (2010)., Synthesis and characterization of a tetraaza macrocyclic ligand and its cobalt (II), nickel (II) and copper(II) complexe., J. Serb. Chem. Soc., 75(7) 935–941.
  24. Chandra S., Tyagi M. and Agarwal S. (2010)., Antibacterial and antifungal activity of Schiff base ligands and their metal complexes., Serb. Chem. Soc., 75(7), 935–941.
  25. Hunter T.M., Paisley S.J. and Park H.S. (2004)., Investigations of internal mannich Reactions., J. Inorg. Biochem, (98), 713
  26. Athira C.J., Sindhu Y., Sujamo M.S. et. al. (2006)., Synthesis and spectroscopic characterization of some Lanthanide (III) nitrate complexes of ethyl 2-[2-(1-acetyl-2- -isopropyl) Azo]-4,5-dimethyl-3-thiophenecarboxyat., Russ. J. Coord. Chem., 76(2), 249-261.