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Green Synthesis of 2,4,5-trisubstituted Imidazole Derivatives using Silica Tungstic Acid as an Efficient Catalyst

Author Affiliations

  • 1Department of Chemistry, Sant Gadge Baba Amravati University, Amravati, 444602, India
  • 2Department of Chemistry, Sant Gadge Baba Amravati University, Amravati, 444602, India
  • 3Department of Chemistry, Sant Gadge Baba Amravati University, Amravati, 444602, India
  • 4Department of Chemistry, Sant Gadge Baba Amravati University, Amravati, 444602, India

Res.J.chem.sci., Volume 6, Issue (11), Pages 36-39, November,18 (2016)


Synthesis of 2,4,5-trisubstituted imidazole derivatives via one-pot three components reaction of benzil, aldehydes and ammonium acetate by using silica tungstic acid as an efficient catalyst. The reaction was performed under mild reaction conditions with microwave irradiation as an energy source. Compared with the classical reaction conditions, this method has an advantage of significant enhance in yields (86–95%). The advantages of this protocol include the excellent yield, operational simplicity, short reaction time and avoidance the excess use of organic solvents. The catalyst was separated and reused for several time cycles without any significant loss of activity. Products were identified using physical and IR, 1H and 13C NMR, MS spectroscopic technique.


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