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Thermodynamics of Complexation of Mn (II) Metal Ion with Amoxicillin

Author Affiliations

  • 1LCIT College of C and S, Bodri, Bilaspur, CG, India
  • 2Govt Agrasen College, Bilha, Bilaspur, CG, India

Res.J.chem.sci., Volume 6, Issue (10), Pages 51-53, October,18 (2016)


In recent time study of metal complexes a re used immensely in medicine in the design of slow rele ase and long acting drugs. Now a day the study of chemistry of metal-drug interaction has become more popular in the de sign of more biologically active drugs. The present work comprise s Potentiometric studies of complexation of amoxicillin with Mn (II) ions in 50% aqueous ethanol medium at three differe nt temperatures (30, 35 and 40oC) and at 0.1 M (NaNO 3) ionic strength. Calvin-Bjerrum pH titration process as used by Irving and Rossotti is used for the calculation of stabil ity constants of the metal complexes. It is observed that Mn (II) ion s form 1:1 and 1:2 complexes. Various thermodynamic parameters eg. Gibbs free energy change ( G), enthalpy changes ( H) and entropy changes ( S) have also been calculated, which shows formation of metal complexes to be spontaneous, exoth ermic and stability of complexes at lower temperature.


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