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Physico-Chemical and Biological Analysis of N-4-Disubstituted Thiosemicarbazone Ligand and its Transition Metal Complexes

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Author Affiliations

  • 1Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, MS, India

Res.J.chem.sci., Volume 6, Issue (1), Pages 16-21, January,18 (2016)

Abstract

The Cr(III), Mn(II), Fe(II) and Ni(II) transition metal complexes of novel (E)-1-(2-hydroxybenzylidene)-4,4diethylthiosemicarbazide have been prepared and characterized by micro anaysis (elemental), spectral (FTIR, 1H-NMR), molar conductivity and X-ray diffraction studies. A molar conductivity measurement shows that, Cr (III) and Fe (II) complex of ligand (HBDT) are electrolytic in nature. FTIR studies suggested the attachment of central metal ion to ligand portion through the imine linkage-nitrogen, thioketonic sulphur and phenolic oxygen. According to spectral studies an octahedral geometry may be assigned for all four complexes. The ligand (HBDT) and its transition metal complexes have also been tested for their antibacterial and antifungal activity against Staphylococcus aureus, Bacillus substilis, Aspergillus niger and Fusarium oxysporium species. All complexes and ligand showed considerable activity compared with standard drug ciprofloxacin.

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