International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN.  International E-Bulletin: Information/News regarding: Academics and Research

Synthesis, Characterization and Antimicrobial activity of chitosan 4-chlorobenzaldebyde Schiff base

Author Affiliations

  • 1Arunai Engineering College, Tiruvannamalai, Tamil Nadu, INDIA
  • 2 Department of Chemistry, Thiruvalluvar University, Vellore, Tamil Nadu, INDIA

Res.J.chem.sci., Volume 5, Issue (9), Pages 27-33, September,18 (2015)


A chemical compound or mixture of compounds made up of repeated structural units formed through a process of polymerization is termed as polymer. In past decades, researchers were focused on biodegradable for its applications in the field of tissue engineering, gene therapy; wound healingand controlled drug delivery system. In our present work, Schiff base was prepared by reacting chitosan with p-clorobenzaldehyde. The derivative was characterized by FTIR spectroscopy, TGA, DSC, XRD, SEM and tested towards the cell uptake. The uncross linked chitosan Schiff base derivative was studied for its antimicrobial activities.


  1. Ammar Bin Saeed, Muddassar Siddique., Naveed Aslam Dogar and Sohail Ahmad, Biological potential of synthetic hydrazide based Shiff bases, JSIR., 2(3), 651-657 (2013)
  2. Raghuwanshi P.B. and Mahalle P.V., Synthesis of substituted Schiff’s bases and their antimicrobial activity, DerPharmaChemica., 6(1), 262-266 (2014)
  3. Gholamhossein Grivani, Giuseppe Bruno, Hadi Amiri Rudbari, Aliakbar Dehno Khalaji and Pegah Pourteimouri, Synthesis, characterization and crystal structure determination of a new oxovanadium(IV) Schiff base complex: The catalytic activity in the epoxidation of cycloocten, Inorganic chemistry communications, 18, 15-20 (2012)
  4. Tirkistani F.A.A., Thermal analysis of some chitosan Schiff bases, Polymer Degradation and Stability, 61(1), 161–164 (1998)
  5. Kogel Knaber, Analytical approaches for characterizing soil organic matter, Org. Geochem., 609-625 (2000)
  6. Sixun Zheng, Jinyu Huang, Yongcan Li and Qipeng GuoA, DSC Study of miscibility and phase separation incrystalline polymer blends of phenolphthalein poly(ether ethersulfone) and Poly (ethylene oxide), Miscibility and phase separation in PES-C/PEO blends, John Wiley and Sons, Inc., 1383–1392 (1996)
  7. Mohammad Saleem Khan, Uzma Khalil and Gulfam Nasar, XRD Study of Binary Polymer Blend of PMMA/PVAC., J Pak Mater Soc., 3(1), 22-26 (2009)
  8. Jung B.O., Kim C.H., Choi K.S., Lee Y.M. and Kim J., Preparation of amphipilic chitosan and their antimicrobial activities., J. Appl. Polym. Sci., 722, 1713-1719 (1999)
  9. Limam Z., Selmi S., Sadok S. and Elabed A., Extraction and characterization of chitin and chitosan from crustacean by-products: biological and physicochemical properties, African J. of Biotechnology., 10(4), 640-647 (2011)
  10. Knorr D, Recovery and utilization of chitin and chitosan in food processing waste management, Food Technol., 45, 114-122 (1991)