Compositional analysis and Antimycobacterium Tuberculosis Activity of Essential Oil of Hyptis Suaveolens Lamiceae

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Compositional analysis and Antimycobacterium Tuberculosis Activity of Essential Oil of Hyptis Suaveolens Lamiceae

Author Affiliations

¹ Department of Chemistry, School of Pure and Applied Science Modibbo Adama University of Technology P.M.B. 2076 Yola Adamawa State NIGERIA

Res.J.chem.sci., Volume 5, Issue (7), Pages 40-44, July,18 (2015)

Abstract

Fresh leaves of Hyptis suaveolens were collected and pretreated for essential oil analysis with the sole aim of linking the ethnomedicinal uses of this plant by the people of Adamawa State Nigeria to its essential oil composition. The results obtained from the analysis shows that 68 compounds were present in varying concentration out of which 16 compounds have appreciable concentration making 75.135 % of the total abundance. The major compound being Caryophyllene (20.643 %) followed by Sabinene (16.711 %) and Terpinolene (8.490 %). The essential oil of Hyptis suaveolens also showed anti mycobacterium activity when tested on strain 7H9/ADC with MIC of 3.13 %. This activity was compared with standard drug Rifampicin which also has MIC of 0.1 痢/ml.

References

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Kirtikar K.R. and Basu B.D., Indian Medicinal Plants, Singh B and Singh M.P. Publishers India., 3, 2032 (1991)
Annie S., Rhadika S., Udupa A.L., Udupa S.L. and Somashekar S., Wound Healing Property of Ethanolic Extract of Leaves of Hyptis suaveolens with supportive role of Antioxidant Enzymes, Ind. J. of exp. Bio., 41(3),238-241 (2003)
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Okonogi S., Chansakaow S., Vejabhikul S., Tharavichikul P., Herphokanount J, Nakano A. and Ikegami F., Antimicrobial Activity and Pharmaceutical Development of Essential oil from Hyptis suaveolens. Proc. WOCAMP.,3(4), 163 (2005)
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[ref1] Kingston D.G., Rao. M.M. and Zucker W.V., Plant Anticancer against IX Constituent of Hyptis suaveolens, J. of Nat. pro.,42(5 496-499 (1997)

[ref2] The wealth of India (Raw materials), CSIR New Delhi., 5, 159 (1964)

[ref3] Kirtikar K.R. and Basu B.D., Indian Medicinal Plants, Singh B and Singh M.P. Publishers India., 3, 2032 (1991)

[ref4] Annie S., Rhadika S., Udupa A.L., Udupa S.L. and Somashekar S., Wound Healing Property of Ethanolic Extract of Leaves of Hyptis suaveolens with supportive role of Antioxidant Enzymes, Ind. J. of exp. Bio., 41(3),238-241 (2003)

[ref5] Chatterjee A. and Pakrashi S.C., The Treatise on Indian Medicinal Plants, PID, New Delhi: 5, 15 (1997)

[ref6] Chitra S., Patil M.B. and Ravi K., Wound Healing Activity of Hyptis suaveolens (L)Poit, Int. J. of Pharm. Tech. Res., 1(3), 737-744 (2009)

[ref7] Umedum N.L., Nwajagu U., Udeozo I.P., Anarado C.E. and Egwuatu C., The efficacy of Hyptis suaveolens: A review of its Nutritional and Medicinal Application, Eur. J. of Medi. Pl., 4(6) 661-674 (2014)

[ref8] Carson C.F. and Riley T.V., Antimicrobial Activity of a Major Component of the Essential oil of Melaleuca alternifolia. J. of App. Bacterio.,78(3), 264-269 (1995)

[ref9] Ramzi A.M., Mansour S.A., Mohammed A.A., Adnan J.A. and Jamal M.K., GC and GC/MS Analysis of Essential Oil Composition of the Endemic Soqotraen Leucas virgata Balf. f. and Its Antimicrobial and Antioxidant Activities. Int. J. Mol. Sci.,14(11), 23129-23139; doi:10.3390/ijms141123129 (2013)

[ref10] Giovanni B., Guido F., Angelo C., Illaria M., Pier L.C and Barbara C., Repellent of Hyptissuaveolens whole Essential oil and major Constituents against Adult of Granary weevil sitophilus granaries. Bullet. of insectol., 65(2), 177-183 (2012)

[ref11] Chatri M., Amri B. and Mansyurdin P.A., Chemical Components of Essential oils of the Leaves of Hyptis suaveolens (L) poit from Indonesia, Amer. J. of Res. Comm.,2(10), 30-38 (2014)

[ref12] Sharma N., Verma U.K. and Tripatti A., Bioactivity of Essential oil from Hyptissuaveolens against Storage mycoflora. Proc. Inc. cont. Controlled Atmosphere and Fumigation in Stored Product, Gold-cast Austrilia. 8-13thFTIC Ltd. Publishing, Israel., 99-116 (2007)

[ref13] Okonogi S., Chansakaow S., Vejabhikul S., Tharavichikul P., Herphokanount J, Nakano A. and Ikegami F., Antimicrobial Activity and Pharmaceutical Development of Essential oil from Hyptis suaveolens. Proc. WOCAMP.,3(4), 163 (2005)

[ref14] Fun C.E and Baerheim A.S., The Essential oil of Hyptis suaveolens poit Grown on Aruba. 10. 1002/ffj.2730080306, available on linelibrary.wiley.com visited., 14-6-2015 (2006)

[ref15] Azevedo N.R., Campos I.F., Ferreira H.D., Portes T.A., Santos S.C. Seraphin J.C and Ferri P.H., Chemical Variability in the Essential oil of Hyptis suaveolens. U. S Nat. lib. of Med. Nat. Inst. of Health,57(5), 733-6 (2001)

[ref16] Koba K., Raymoud C., Millet J., Chaumout J.P. and Sanda K., Chemical Composition of Hyptis pectinataL.H. lanceolata poit H. Suaveolens L and H. spicigeraLam, Essential oil from Togo, J.of Essent.oil Bea. Pl.10(5), 357-364 (2007)

[ref17] Dorman H.J.D. and Deans S.G., Antimicrobial Agent from Plant: Antibacterial Activity of Plant Volatile oils, J. of App. Microbiol.,88, 308-316 (2000)