5th International Young Scientist Congress (IYSC-2019).  International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN.  International E-Bulletin: Information/News regarding: Academics and Research

Metal Complexes of Quinoxaline Derivatives: Review (Part-II)

Author Affiliations

  • 1Department of Chemistry, University College of Engineering, Nagercoil, Anna University Constituent College, Nagercoil 629004, Tamil Nadu, INDIA

Res.J.chem.sci., Volume 5, Issue (4), Pages 64-84, April,18 (2015)

Abstract

Over the past decades, there is increasing information about synthesis, characterization and applications of metal complexes including quinoxaline derivative metal complexes. The focus of the review is emphasized on synthesis, characterization, structural analysis, theoretical calculations and biological studies of quinoxaline derivative metal complexes. These types of review provide unique platform for systematically studying the various quinoxaline derivative metal complexes synthesized so far and their characterizations. We have also highlighted the synthetic strategies developed to synthesize metal complexes. Several characterizations which are not covered in part-I like CD-spectroscopy are also included in this review paper. This review is also a focus of the reports on the structural aspects that the quinoxaline based ligands plays on compounds reported in last seven years. Furthermore in this review the current progress of research in the field of quinoxaline derivative metal complexes from 2007 to end of 2014 is summarized. The structure was confirmed by single crystal x-ray diffraction studies. An overview of application of quinoxaline derivative metal complexes is also presented. Structural elucidation using Density Functional Theory (DFT) and Time Dependent-Density Functional Theory (TD-DFT) are included. In addition to various biological studies included in the previous part, cytotoxicity, photo cytotoxicity studies, anti-tubercular studies, insulin mimetic activity, anti-trypanosome cruzi activity, anti-proliferative activities are included.

References

  1. Rahman L.H.A. and Ramadan R.M., Synthesis and characterization of some new mono- and binuclear copper(II) ternary complexes; X-ray crystal structure of copper(II)- -(acetyl)phenylglycinate–imidazole ternary complex, J Coord Chem, 60, 1891 (2007)
  2. Lo K.K. W. and Lee T.K.M., Luminescent ruthenium(II) amidodipyridoquinoxaline biotin complexes that display higher avidin-induced emission enhancement, Inorg Chim Acta, 360, 293 (2007)
  3. Roy M., Patra A.K., Mukherjee A., Nethaji M. and Chakravarty A.R., Indian J Chem Section A Inorganic, Physical, Theoretical and Analytical Chem, Ternary iron(II) complexes of phenanthroline bases showing DNA binding and cleavage activity, 46, 227 (2007)
  4. Miao R. and Brewer K.J., A structurally diverse mixed-metal complex with mixed bridging ligands [{[(bpy)Os(dpp)]Ru}(dpq)](PF12: Modulating orbital energetics within a supramolecular architecture, Inorg Chem.Comm, 10, 307 (2007)
  5. Wu Y.B., Xiong Z.H., Chen H.L. and Yang P., [Co(phen)dpq]3+-sheared DNA interactions: Investigation into the basis for major groove recognition and repair, J Mol Struct Theochem,806, 247 (2007)
  6. Wang X., Bi Y., Lin H. and Liu G., Three Novel Cd(II) Metal Organic Frameworks Constructed from Mixed Ligands of Dipyrido[3,2-:2‘,3‘-]quinoxaline and Benzene-dicarboxylate: From a 1-D Ribbon, 2-D Layered Network, to a 3-D Architecture, Crystal Growth and Design, 1086 (2007)
  7. Plitt P., Gross D.E., Lynch V.M. and Sessler J.L., Dipyrrolyl-Functionalized Bipyridine-Based Anion Receptors for Emission-Based Selective Detection of Dihydrogen Phosphate, Chemistry - A European Journal, 13, 1374 (2007)
  8. Kemp S., Wheate N.J., Buck D.P., Nikac M., Collins J.G. and Aldrich-Wright J.R. , The effect of ancillary ligand chirality and phenanthroline functional group substitution on the cytotoxicity of platinum(II)-based metallointercalators, J Inorg Biochem, 101, 1049 (2007)
  9. Lo K.K., Sze K.S., Tsang K.H. and Zhu N, Luminescent Tricarbonylrhenium(I) Dipyridoquinoxaline Indole Complexes as Sensitive Probes for Indole-Binding Proteins, Organometallics, 26, 3440 (2007)
  10. Biyikliolu Z., Ertem B., Karsliolu S. and Gök Y., Trans Met Chem, Synthesis and characterization of novel ()-dioxime and its mono- and polynuclear metal complexes containing azacrown moieties, 32, 591 (2007)
  11. Ghosh M., Biswas P. and Flörke U., Structural, spectroscopic and redox properties of transition metal complexes of dipyrido[3,2-:2,3]-quinoxaline (dpq), Polyhedron, 26, 3750 (2007)
  12. Mostafa S. I., Mixed ligand complexes with 2-piperidine-carboxylic acid as primary ligand and ethylene diamine, 2,2-bipyridyl, 1,10-phenanthroline and 2(2pyridyl)quinoxaline as secondary ligands: preparation, characterization and biological activity, Trans Met Chem, 32, 769 (2007)
  13. Therrien B., Süss-Fink G., Govindaswamy P. and SaïdMohamed C., Mono and dinuclear arene ruthenium complexes containing 6,7-dimethyl-2,3-di(pyridine-2yl)quinoxaline as chelating ligand: Synthesis and molecular structure, Polyhedron,26, 4065 (2007)
  14. Kong Z. -G., Li W. -L., Wang D., Chen L. -L. and Zhang G., J Functional Mat, 38,1575 (2007)
  15. Wang X., Fang J., Bi Y., Zhao H., Chen B., Lin H. and Liu G., Self-assembled multilayer films of poor water-soluble copper(II) complexes constructed from dipyrido[3,2-:2,3]quinoxaline (Dpq) ligand as well as their fluorescent properties, J Solid State Chem., 180, 2950 (2007)
  16. Lin T. -P., Chen C. -Y., Wen Y. -S. and Sun S. -S.Hydroxide-Promoted Core Conversions of Molybdenum Iron Sulfur Edge-Bridged Double Cubanes: Oxygen-Ligated Topological P Clusters,Inorg Chem, 46, 9201 (2007)
  17. Brodie C. R. and Aldrich-Wright J. R., Synthesis of Flexible Bis-Intercalating Ruthenium(II) Complexes, Eur J Inorg Chem, 4781 (2007)
  18. Bilgin A., Ertem B. and Gök Y., Synthesis and Characterization of a Novel Quinoxaline-Substituted vicDioxime and Its Complexes Containing Bis(12-Diazacrown-4) Derivatives, Bull Chem Soc Jpn,80, 1549 (2007)
  19. Sasmal P.K., Patra A.K., Nethaji M. and Chakravarty A.R., DNA Cleavage by New Oxovanadium(IV) Complexes of -Salicylidene -Amino Acids and Phenanthroline Bases in the Photodynamic Therapy Window, Inorg Chem, 46, 11112 (2007)
  20. Roy M., Pathak B., Patra A.K., Jemmis E.D., Nethaji M. and Chakravarty A.R., New Insights into the VisibleLight-Induced DNA Cleavage Activity of Dipyridoquinoxaline Complexes of Bivalent 3d-Metal Ions,Inorg Chem, 46, 11122 (2007)
  21. Durmus M., Dioncer F. and Ahsen V., The synthesis and spectroscopic characterization of alkoxy substituted 2,2azoquinoxaline and its palladium complex,Dyes Pigments, 77, 402 (2008)
  22. Mitsopoulou C.A., Dagas C. E. and Makedonas C., Synthesis, characterization, DFT studies and DNA binding of mixed platinum (II) complexes containing quinoxaline and 1,2-dithiolate ligands, J Inorg Biochem,102, 77 (2008)
  23. Urquiola C., Gambino D., Cabrera M., Lavaggi M. L., Cerecetto H., González M., de Cerain A. L., Monge A., Costa-Filho A. J. and Torre M. H. , New copper-based complexes with quinoxaline -dioxide derivatives, potential antitumoral agents, J Inorg Biochem, 102, 119 (2008)
  24. Das A. K., Balak E., Sarkar B., Lissner F., Scheild T., Neimeyer M., Fielder J. and Kaim W., Structures and Redox Properties of Metal Complexes of the ElectronDeficient Diphosphine Chelate Ligand -QuinoxP, Organometallics, 27, 218 (2008)
  25. Konidaris K. F., Perlepes S. P., Aromi G., Teat S. J., Escuer A. and Manessi-Zoupa E., First use of 1,4-dihydro-2,3-quinoxalinedione in the chemistry of coordination polymers: A 3D copper(II) complex containing the 2,3-dioxyquinoxalinate( 2) ligand in a novel coordination mode, Inorg Chem Comm, 11, 186 (2008)
  26. Du J. -L., Hu T. -L., Li J. –R., Zhang S. -M. and Bu X. -H., Metal Coordination Architectures of 2,3-Bis(triazol-1-ylmethyl)quinoxaline: Effect of Metal Ion and Counterion on Complex Structures, Eur J Inorg Chem, 1059 (2008)
  27. Wang X. -L., Bi Y. -F., Liu G. -C., Lin H. -Y., Hu T. -L. and Bu X. -H.n(II) coordination architectures with mixed ligands of dipyrido[3,2-d,3-f]quinoxaline/2,3-di-2-pyridylquinoxaline and benzenedicarboxylate: syntheses, crystal structures, and photoluminescence properties, Cryst Eng Comm,10, 349 (2008)
  28. Kozlov L. and Goldberg I., Supramolecular interaction patterns in the zinc(II) dichloride and tin(IV) tetrachloride complexes with dipyrido[]quinoxaline-6,7-dicarbonitrile, Acta Crystallographica Section C: Crystal Structure Communications, 64, m123 (2008)
  29. Fitchett C. M. and Steel P. J.,Synthesis and X-ray crystal structures of metal complexes of three isomeric bibenzodiazines: Discrete and polymeric assemblies, Polyhedron, 27, 1527 (2008)
  30. Rajendiran V., Murali M., Suresh E., Palaniandavar M., Periasamy V. S. and Akbarsha M. A., Non-covalent DNA binding and cytotoxicity of certain mixed-ligandruthenium(II) complexes of 2,2dipyridylamine and diimines, Dalton Trans, 2157 (2008)
  31. Mitsopoulou C. A., Dagas C. E. and Makedonas C., Characterization and DNA interaction of the Pt(II)(pq)(bdt) complex: A theoretical and experimental research, Inorg Chim Acta, 361, 1973 (2008)
  32. Biswas P., Dutta S. and Ghosh M., Influence of counter anions on structural, spectroscopic and electrochemical behaviours of copper(II) complexes of dipyrido[3,2-f: ,3-h]-quinoxaline (dpq), Polyhedron,27, 2105 (2008)
  33. Roy S., Patra A. K., Dhar S. and Chakravarty A. R., Photosensitizer in a Molecular Bowl and its Effect on the DNA-Binding and -Cleavage Activity of 3d-Metal Scorpionates Inorg. Chem, 47, 5625 (2008)
  34. Wang X. -L., Lin H. -Y., Liu G. -C., Zhao H. -Y. and Chen B. -K., Synthesis, structures, electrochemistry and electrocatalysis of two novel copper(II) complexes constructed with aromatic polycarboxylates and dipyrido[3,2-d:2,3-f]quinoxaline, J Organometallic Chem, 693, 2767 (2008)
  35. Patra A. K., Bhowmick T., Ramakumar S., Nethaji M. and Chakravarty A. R., DNA cleavage in red light promoted by copper(II) complexes of -amino acids and photoactive phenanthroline bases, Dalton Trans, 6966 (2008)
  36. Lahiri D., Bhowmick T., Pathak B., Shameema O., Patra A. K., Ramakumar S. and Chakravarty A. R., Anaerobic Photocleavage of DNA in Red Light by Dicopper(II) Complexes of 3,3-Dithiodipropionic Acid, Inorg Chem, 48, 339 (2009)
  37. Howard M., Heirtzler F. and Dias S., Synthesis and Stereochemistry of Long-Chain Quinoxaline Metallocyclophanes, J Org Chem, 73, 2548 (2008)
  38. Masssoud A. A., Langer V., Ohrstrom L. and Abu-Yusuff M. A. M., Two 2-D copper(II) azido compounds:catena-poly[di1,1- azido, diN,O(quinolinecarboxylato) (aqua)copper(II)] and 1-D catenapoly [diN,N-(quinoxaline) copper(II)nitrate], J Coord Chem, 62, 519 (2009)
  39. Choua S., Djukic P. J., Dallery J., Bieber AWelter., R., Gisselbrecht J. P., Turek P. and Ricard L., Stable and Highly Persistent Quinoxaline-Centered Metalloorganic Radical Anions: Preparation, Structural, Spectroscopic, and Computational Investigations, Inorg Chem, 48, 149 (2009)
  40. Bolink H. J., Coronado E. and Sessolo M., White Hybrid Organic Inorganic Light-Emitting Diode Using ZnO as the Air-Stable Cathode, Chem Mat, 21, 439 (2009)
  41. Urquiola C., Vieites M., Torre M. H., Cabrera M., Lavaggi M. L., Cerecetto H., González M., Cerain A. L., Monge A., Smircich P., Garat B. and Gambino D., Cytotoxic palladium complexes of bioreductive quinoxaline-dioxide prodrugs, Bioorg Med Chem, 17, 1623 (2009)
  42. Lin H., Wang X., Hu H., Chen B. and Liu G., A novel copper(II) complex constructed with mixed ligands of biphenyl-4,4-dicarboxylic acid (Hbpdc) and dipyrido[3,2-d:2,3-f]quinoxaline (Dpq): Synthesis, structure, electrochemistry and electrocatalysis, Solid State Sciences, 11, 643 (2009)
  43. Maity B., Roy M., Saha S. and Chakravarty A. R., Photoinduced DNA and Protein Cleavage Activity of Ferrocene-Conjugated Ternary Copper(II) ComplexesOrganometallics, 28, 1495 (2009)
  44. Saha S., Majumdar R., Roy M., Dighe R. R. and Chakravarty A. R., An Iron Complex of Dipyridophenazine as a Potent Photocytotoxic Agent in Visible Light, Inorg Chem, 48, 2652 (2009)
  45. Lee H.S., Ahn S. A. and Ha Y., Synthesis and the Luminescent Study of the Iridium Complexes Containing 2,3-Diphenylquinoline Derivatives and the New Ancillary Ligand for OLED,Mol Cryst Liq Cryst, 514, 344 (2009)
  46. Tarallo M. B., Costa-Filho A. J., Viera E. D., Monge M., Leite C.Q. Pavan, F. R., Borthangaray G., Gambino D. and Torre M. H., Research of new mixed-chelate copper complexes with quinoxaline N1,N4-dioxide derivatives and alanine as ligands, potential antimycobacterial agents. TheJ Arg Chem Soc, 97, 80 (2009)
  47. Patra A. K., Bhowmick T., Roy S., Ramakumar S. and Chakravarty A. R., Copper(II) complexes of L-arginine as netropsin mimics showing DNA cleavage activity in red light,Inorg Chem,482932 (2009)
  48. Cui Y. -C., Huang Y. -J. and Du G., Chinese J Inorg Chem, 25, 734 (2009)
  49. Konidaris K. F., Papaefstathiou G. S., Aromi G., Teat S. J., Manessi-Zoupa E., Escuer A. and Perlepes S. P., A three-dimensional copper(II) coordination polymer featuring the 2,3-dioxyquinoxalinate(-2) ligand: Preparation, structural characterization and magnetic study, Polyhedron, 28, 1646 (2009)
  50. Amin A. S., Saber A. L. and Mohammed T. Y., Study on solid phase extraction and spectrophotometric determination of vanadium with 2,3-dichloro-6-(2,7-dihydroxy-1-naphthylazo)quinoxaline, Spectrochim Acta , 73, 195 (2009)
  51. Kraft S. S., Bischof C., Loos A., Braun S., Jafarova N. and Schatzschneider U., J Inorg Biochem, A [4+2] mixed ligand approach to ruthenium DNA metallointercalators [Ru(tpa)(N-N)](PF(6))(2) using a tris(2-pyridylmethyl)amine (tpa) capping ligand, 103, 1126 2009
  52. Kulkarni M.S., Kumbhar A.S., Mohan H. and Rao B.S.M., Synthesis, characterization and redox chemistry of Ru(II) complexes of N-methyl pyridyl quinoxaline, Dalton Trans, 6185 (2009)
  53. Pladzyk A. and Baranowska K., Cobalt(II) Tri-tertbutoxysilanethiolates with Bidentate Spacer Ligands, Zeitschrift fur Anorganische und Allgemeine Chemie, 635, 1638 (2009)
  54. Soriano M.L., Jalón F.A., Manzano B.R. and Maestro M., Synthesis and characterization of Ru(arene) complexes of bispyrazolylazines: Catalytic hydrogen transfer of ketones, Inorg Chim Acta,362, 4486 (2009)
  55. Lakshmi P.V.A., Reddy P.S. and Raju V.J., Synthesis, characterization and antimicrobial activity of 3d transition metal complexes of a biambidentate ligand containing quinoxaline moiety, Spectrochim Acta , 74, 52 (2009)
  56. Si Z., Li X., Li X., Pan C. and Zhang H., Synthesis, photoluminescence, and theoretical studies of novel Cu(I) complex,Inorg Chem Comm, 12, 1016 (2009)
  57. Huangyan -J., Cui Y. -C. and Du G., Hydrothermal Synthesis and Crystal Structure of a Zero-Dimensional Copper() Complex with Isophthalic Acid and Medpq Ligands, Chinese J Inorg Chem,25, 1882 (2009)
  58. Choua S., Djukic J., Jerome, Bieber A., Welter R., Gisselbrecht J., Turek P. and Ricard, Stable and Highly Persistent Quinoxaline-Centered Metalloorganic Radical Anions: Preparation, Structural, Spectroscopic, and Computational Investigations,Inorg Chem,48, 149 (2009)
  59. Zapata F., Caballero A., Espinosa A., Tárraga A. and Molina P., A Selective Redox and Chromogenic Probe for Hg(II) in Aqueous Environment Based on a Ferrocene Azaquinoxaline Dyad,Inorg Chem,48, 11566 (2009)
  60. Yanilkin V. V., Nastapova N. V., Stepanov A. S., Kalinin A. A. and Mamedov V. A., Voltammetric study of metal ions binding by biindolizine heterocyclophanes and their acyclic analogues, Russian J Electrochem, 46, 49 (2010)
  61. Sceidenbach D., Ammermann S., Bebeaux M., Freund A., Zollner M., Daniliue C., Jones P. G., Kowalsky W. and Johannes H., Efficient and Long-Time Stable Red Iridium(III) Complexes for Organic Light-Emitting Diodes Based on Quinoxaline Ligands,Inorg Chem, 49, 397 (2010)
  62. Zhang K. Y., Li S. P. -Y., Zhu N., Or L. W. -S., Cheung M. S. -H., Lam Y. -W. and Lo K. K. –W., Efficient and Long-Time Stable Red Iridium(III) Complexes for Organic Light-Emitting Diodes Based on Quinoxaline Ligands,Inorg Chem, 49, 2530 (2010)
  63. Hussain A., Lahiri D., Begum M. S. A., Sabu S., Majumdar R., Dighe R.R. and Chakravarty A. R., Photocytotoxic Lanthanum(III) and Gadolinium(III) Complexes of Phenanthroline Bases Showing Light-Induced DNA Cleavage Activity, Inorg Chem, 49, 4036 (2010)
  64. Jiang W., Gao Y., Sun Y., Ding F., Xu Y., Bian Z., Li F., Bian J. and Huang C., Zwitterionic Iridium Complexes: Synthesis, Luminescent Properties, and Their Application in Cell Imaging, Inorg Chem, 49, 3252 (2010)
  65. Islam M.N., Kumbhar A.A., Kumbhar A.S., Zeller M., Butcher R.J., Dusane M.B. and Joshi B.N., Bis(maltolato) vanadium (III)-Polypyridyl Complexes: Synthesis, Characterization, DNA Cleavage, and Insulin Mimetic Activity, Inorg Chem,49, 8237 (2010)
  66. Lo K.K.W. and H. Leung A.H., Luminescent cyclometalated iridium(III) dipyridoquinoxaline indole complexes as biological probes, Science China Chemistry.53, 2091 (2010)
  67. Badawy M. A., Mohamed G. G. and Omer M. M., Synthesis, spectroscopic and thermal characterization of quinoxaline metal complexes, Eur J Chem,, 282 (2010)
  68. Deshpande M. S., Kumbhar A. S. and Näther C., Stabilization of acyclic water tetramer in a copper(II) malonate framework structure,Dalton Trans,39, 9146 (2010)
  69. Tarallo M. B., Urquiola C., Monge A., Costa B. P., Ribeiro R. R., Costa-Filho A. J., Mercader R. C., Pavan F. R., Leite C. Q. F., Torre M. H. and Gambino D., Design of novel iron compounds as potential therapeutic agents against tuberculosis, J. Inorg. Biochem104, 1164 (2010)
  70. Tsierkezos N., Athanassios R., Poulos I. P. and Schroders D., Electrochemical studies of the bis (triphenyl phosphine) ruthenium(II) complex, cis -[RuCl(L)(PPh], with L = 2-(2-pyridyl)quinoxaline,J Coord Chem, 63, 3517 (2010)
  71. Finagenova G. O., Nikiforova A. A., Puzyk M. V. and Balashev K. P., Mixed-ligand Pt(II) and Pd(II) complexes on the basis of cyclometalated 2-phenylpyridine and polypyridyl ligands, Russian J Gen Chem, 78, 1780 (2008)
  72. Hu Y., Li Q. -Q., Li H., Guo Q. -N., Lu Y-GLi. and Z. -Y., A novel class of Cd(II), Hg(II) turn-on and Cu(II), Zn(II) turn-off Schiff base fluorescent probes, Dalton Trans, 39, 11344 (2010)
  73. Huang Y. -J., Ni L., Du G. and Wang L., Jiegou Huaxue, 29, 1857 (2010)
  74. Du Y., Zhao Y. -L., Fu X. –T Sun., H. -J. and Li X., Synthesis and fluorescence properties of complexes of terbium with red fluorescence,Spectroscopy and Spectral Analysis, 31, 158 (2011)
  75. Huangyan. -J., Ni L., Wang L. and ZhuC., Hydrothermal Synthesis, Characterization and Natural Bond Orbital(NBO) Analysis of [Ni(Pht) (Medpq)(HO) Complex, Chinese J Inorg Chem, 27, 157 (2011)
  76. SHiggins. L. H., White T. A., Winkel B. S. J. and Brewer K. J., Redox, spectroscopic, and photophysical properties of Ru-Pt mixed-metal complexes incorporating 4,7-diphenyl-1,10-phenanthroline as efficient DNA binding and photocleaving agents, Inorg Chem,50, 463 (2011)
  77. Bulak E., Varnali T., Schwederski B., Sarkar B., Hartenbach I., Fiedler J. and Kaim W., 2,3-Bis(1-methylimidazol-2-yl)quinoxaline (bmiq), a new ligand with decoupled electron transfer and metal coordination sites: the very different redox behaviour of isoelectronic complexes with [PtCl] and [AuClDalton Trans,40, 2757 (2011)
  78. Budagumpi S., Kulkarni N. V., Sathisha M. P., Netalkar S. P., Revankar V. K. and Suresh D. K., Exploration on structure and anticonvulsant activity of transition metal complexes derived from an ‘end-off’ compartmental oligoquinoxaline derivative with phthalazyl-diazine as endogenous bridge, Monatshefte fur Chemie,142, 487 (2011)
  79. Sproules S., Eagle A. A., Taylor M. K., Gable R. W., White J. M. and Young C. G., Paramagnetic oxotungsten(V) complexes containing the hydrotris(3,5-dimethylpyrazol-1-yl)borate ligand, Inorg Chem,50, 4503 (2011)
  80. Bolligarla R., Durgaprasad G. and Das S. K., Synthesis, molecular structure and supramolecular chemistry of a new nickel-quinoxaline dithiolate system [Bu4N]2 [Ni(6,7-qdt)2] (6,7-qdt=quinoxaline-6,7-dithiolate) Inorg Chem Comm, 14, 809 (2011)
  81. Du J. -L., Wei Z. -Z. and Hu T. -L., Metal coordination polymers of 2,3-bis (benzimidazol-1-ylmethyl) quinoxaline: Syntheses, crystal structures and luminescent properties, Solid State Sciences, 13, 1256(2011)
  82. Ramakrishnan S., Shakthipriya D., Suresh E., Periasamy V. S., Akbarsha M. A. and Palaniandavar M., Ternary dinuclear copper(II) complexes of a hydroxybenzamide ligand with diimine coligands: the 5,6-dmp ligand enhances DNA binding and cleavage and induces apoptosis, Inorg Chem, 50, 6458 (2011)
  83. Knoll J. D., Arachchige S. M., Wang G., Rangan K., Miao R., Higgins S. L. H., Okyere B., Zhao M., Croasdale P., Magruder K., Sinclair B., Wall C. and Brewer K. J., Electrochemical, spectroscopic, andphotophysical properties of structurally diverse polyazine-bridged Ru(II),Pt(II) and Os(II),Ru(II),Pt(II) supramolecular motifs, Inorg Chem,50, 8850 (2011)
  84. Liu X., Li L., Lu J., Chen Y. and Zhang S., Synthesis, DNA-binding, and photocleavage studies of ruthenium(II) complexes with an asymmetric ligand, J Coord Chem,64, 4344 (2011)
  85. Wu J., Li W., Higgins D. and Chen Z., Heat-Treated Nonprecious Catalyst Using Fe and Nitrogen-Rich 2,3,7,8-Tetra(pyridin-2-yl)pyrazino[2,3-g]quinoxaline Coordinated Complex for Oxygen Reduction Reaction in PEM Fuel Cells, J Phys Chem C,115, 18856 (2011)
  86. Xu W. J., Liu S. J., Q. Zhao, Ma T. and Sun S., A near-infrared phosphorescent probe for F based on a cationic iridium(III) complex with triarylboron moieties, Science China Chemistry,54, 1750 (2011)
  87. Varela J., Lessa J. A., Lavaggi M. L., Beraldo H. and Cerecetto H.,Coordination of 3-aminoquinoxaline-2-carbonitrile 1,4-dioxides to antimony(III) as a strategy for anti-Trypanosoma cruziactivity improvement, Med Chem Res Online First, 30 December (2011)
  88. Etiaw S. E. H., Eltaria E., Fayed T. A. and Abdou S. N., Catalytic, Luminescence Activities and Structure of Metal-Organic Frameworks Containing CuCN Building Blocks and Bipodal Bridging Ligands, J Inorg Organometallic Polymers and materials, 21, 465 (2011)
  89. Etiaw S. E. H., Eltaria E., Fayed T. A. and AbdouInorg S. N., Structure and Spectral Characteristics of 3D-Supramolecular Coordination Polymers Based on Copper Cyanide and Dimethylquinoxaline, J. Organometallic Polymers and materials,21, 480 (2011)
  90. Etiaw S. E. H., El-Aziz A., Fouda S., Amar S. A. and El-bendary., Structure, Characterization and Anti-Corrosion Activity of the New Metal–Organic Framework [Ag(qox)(4-ab)], J Inorg Organometallic Polymers and materials,21, 327 (2011)
  91. Park H. R. and Ha Y., Luminescence Comparison of Iridium(III) Complexes Containing Symmetric vs. Asymmetric Quinolinate Ligands, Mol Cryst Liq Cryst,538, 67 (2011)
  92. Lei W., Liang N., Chong Z. and Yan-Ju H., Hydrothermal Syntheses and Crystal Structures of Cobalt() and Cadmium() Complexes with 1,2,4-Benzenetricarboxylic Acid and Pyrazino[2,3-f][1,10]phenanthroline Ligands, Chinese J Inorg. Chem, 27, 2076 (2011)
  93. Zhao Q., Li R. -F., Xing S. -K., Liu X. -M., Hu T. -L. and Bu X. -H., A highly selective on/off fluorescence sensor for cadmium(II), Inorg Chem, 50, 10041 (2011)
  94. Bulak E., Varnali T., Schwederski B., Bubrin D., Fiedler J. and Kaim W., Separation of Metal Binding and Electron Transfer Sites as a Strategy To Stabilize the Ligand-Reduced and Metal-Oxidized Form of [Mo(CO)L], Organometallics, 30, 6441 (2011)
  95. Xu W., Liu S., Zhao Q., Ma T., Sun S., Zhao X. and Huang W., A near-infrared phosphorescent probe for based on a cationic iridium(III) complex with triarylboron moieties, Material Science China Chemistry, 54, 1750 (2011)
  96. Barszcz B., Masternak J., Hodorowicz M. and Jab\noska-Wawrzycka A., Cadmium(II) and calcium(II) complexes with -bidentate ligands derived from pyrazinecarboxylic acid, J Thermal Anal Calorim.108, 971
  97. Hu L., Qin J., Zhou N., Meng Y. -F., Xu Y., Zuo J. -L. and You X. -Z., Synthesis, characterization, and optical properties of new metal complexes with the multi-sulfur 1,2-dithiolene ligand, Dyes Pigments, 92, 1223 (2012)
  98. Chen G. -J., Qiao X., Gao C. -Y., Xu G. -J., Wang Z. -L., Tian J. -L., Xu J. –Y., Gu W., Liu X. and Yan S.-P., Synthesis, DNA binding, photo-induced DNA cleavage and cell cytotoxicity studies of a family of light rare earth complexes,J Inorg Biochem, 109, 90 (2012)
  99. Ginzinger W., Mühlgassner G., Arion V. B., Jakupec M. A., Roller A., Galanski M., Reithofer M., Berger W. and Keppler B. K., A SAR study of novel antiproliferative ruthenium and osmium complexes with quinoxalinone ligands in human cancer cell lines, J Med Chem,55, 3398 (2012)
  100. Wang L., Ni L. and Huangyan. -J., J Yao Jiegou Huaxue, 733 (2012)
  101. Benítez D., Lavaggi M. L., Gambino D., Torre M. H. and Cerecetto H., Effect of complexation of 3-aminoquinoxaline-2-carbonitrile 1,4-dioxides with palladium and copper on their anti-T. cruzi activity, Med Chem Res,21, 1439 (2012)
  102. Rani D. S., Lakshmi P.V.A., Prasad V.K. and Raju V.J., Synthesis and Characterization of VO(II), Fe(II), Co(II), Ni(II) and Cu(II) Complexes of 2,3-bis(3,5-dimethyl-1H- pyrazol-1-yl)
  103. Quinoxaline, Chin J Inorg Chem, 28, 1245 (2012)
  104. Attia A.S., Aziz A.A.A., Alfallous K.A. and El-Shahat M.F., A novel bonding of 6,7-dichloroquinoxlaine-2,3-dione, DCQX, to two molybdenum (0) metal centers: Synthesis, characterization, biological activity studies and semiempirical calculations of [(bpy)Mo(DCQX)Mo(CO)] complex, Polyhedron, 44, 238 (2012)
  105. Li Y.P.,Yang H.R., Zhao Q., Song W.C., Han J. and Bu X.H., Ratiometric and Selective Fluorescent Sensor for Zn2+ as an “Off–On–Off” Switch and Logic Gate, Inorg Chem,51, 9642(2012)
  106. Barszcz B., Masternak J., Hodorowicz M. and Wawrzycka A. J., Cadmium(II) and calcium(II) complexes with -bidentate ligands derived from pyrazinecarboxylic acid, J Therm Anal Calorim, 108, 971 (2012)
  107. Chen A., S. Meng, Zhang J. and Zhang C., Two interesting tetranuclear Ag(I) complexes based on dipyrido[3,2-f:2,3-h]-quinoxaline: Synthesis, structural, luminescence and theoretical studies, Inorg Chem Comm, 35, 276 (2013)
  108. Zhu R., Hu L., Li Y., Song Y. and Zuo J., Syntheses, crystal structures and properties of dinuclear hydrido-tris(3,5-diphenylpyrazol-1-yl)borate complexes with the S coupled and dimerized quinoxaline-2,3-dithiolate ligand, Inorg Chem Comm 3579 (2013)
  109. Attia A. S.,Aziz A. A., Alfallous K. A. and El-Shahat M. F., New diethoxo-bridged dinuclear Cr(III) complexes with derivatives of the quinoxaline-2,3-dione ligand and 2,2-bipyridine as a co-ligand: Syntheses, spectral characterizations, magnetic properties, antimicrobial inhibitory activities and interpretation of the electronic absorption spectra using the ZINDO/S-CI semi-empirical method, Polyhedron 51243(2013)
  110. Chetana P.R,Rao R., Lahiri D., Policegoudra R.S., Sankolli R. and Aradhya M.S., -Oxamido binuclear copper (II) complexes: Synthesis, crystal structure, DNA interaction and antibacterial studies, Polyhedron, 68, 172 (2014)
  111. Canaj A.B., Nodaraki L.E., ´Slepokura K., Siczek M., Tzimopoulos D.I., Lis T. and Milios C.J., A family of polynuclear cobalt complexes upon employment of an indeno-quinoxaline based oxime ligand, RSC Adv, 23068 (2014)
  112. Chakraborty P., Mondal S., Das S., Jana A. D. and Das D., Dicyanamide mediated construction of 1D polymeric networks of quinoxaline with d10 metal ions: Synthesis, thermogravimetric analysis, photoluminescence and a theoretical investigation on the --- interactions, Polyhedron, 70, 11 (2014)
  113. Lizarazo-Jaimes E., Reis P. G., Bezerra F. M., Rodrigues B. L., Monte-Neto R. L., Melo M. N., Frézard F. and Demicheli C., Complexes of different nitrogen donor heterocyclic ligands with SbCl3 and PhSbCl2 as potential antileishmanial agents against SbIII-sensitive and resistant parasites, J Inorg Biochem, 132, 30 (2014)
  114. Nehru S., Arunachalam S., Arun R. and Premkumar K., Polymer–cobalt(III) complexes: structural analysis of metal chelates on DNA interaction and comparative cytotoxic activity, J Biomol Struct Dyn, 32, 1876 (2014)