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Synthesis, Characterization and Antimicrobial Studies of Cinnamaldehydebenzylamine Schiff base Metal ion Complexes

Author Affiliations

  • 1Department of Chemistry, Michael Okpara University of Agriculture Umudike, P.M.B 7267, Umuahia, NIGERIA
  • 2Department of Pure and Industrial Chemistry, University of Port Harcourt, P.M.B, 5323, Port Harcourt, NIGERIA
  • 3 Department of Microbiology, University of Port Harcourt, P.M.B 5323, Port Harcourt, NIGERIA

Res.J.chem.sci., Volume 5, Issue (3), Pages 14-22, March,18 (2015)

Abstract

The Schiff-base ligand cinnamaldehydebenzylamine was prepared via condensation reaction of Benzylamine ,Aminotolune) and Trans-cinnamaldehyde (3-phenylpropenal) in the presence of alcohol and an acid reagent, acetic acid. Using the salts of Fe2+, Ni2+, Cu2+ of the transition elements and the salts of Ce4+ and Gd3+ of the Lanthanide series, the corresponding complexes were prepared in the metal-ligand (M - L) ratio of 1 : 2.. Using the salts of Fe2+, Ni2+, Cu2+ of the transition elements and the salts of Ce4+ and Gd3+ of the Lanthanide series, the corresponding complexes were prepared in the metal-ligand (M - L) ratio of 1 : 2. The prepared complexes were then characterized using the following physical techniques: elemental analysis, melting point determination, Ultra-Violet (UV) spectra analysis, X-Ray Diffraction analysis, Molar conductivity measurement, infra-red (FTIR) spectral analysis and mass spectral studies. They were properly screened for their antimicrobial activity against four bacteria namely, gram positive (Bacillus subtilis, staphylococcus aureus), gram negative (Escherichia coli, salmonella typhii) and two fungal strains (Aspergillus niger and Candida albicans) by measuring the diameter of zone of inhibition. Experimental results show that the biological activity of the synthesized Schiff base increases significantly when the transition metal ions such as Fe2+, Ni2+, Cu2+ were complexed than when the lanthanides such as Ce4+ and Gd3+ were introduced through co-ordination, with the Ni2+ complex having more than 80% antimicrobial activity on tested organisms especially on E coli .

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