International E-publication: Publish Projects, Dissertation, Theses, Books, Souvenir, Conference Proceeding with ISBN.  International E-Bulletin: Information/News regarding: Academics and Research

Ultrasonic Insight into Substituted Thiazoles and its Biological Activity

Author Affiliations

  • 1Department of Chemistry, Vidya Bharti College Karanja (lad) Dist, Washim, M.S., INDIA

Res.J.chem.sci., Volume 5, Issue (3), Pages 69-76, March,18 (2015)


The heterocyclic compounds constitute the largest family of organic compounds. The most common heterocyclic compounds especially thiazole are very much interesting in the study of research area. It has been known to possess wide range of biological and pharmacological activities for long time. In recent year substituted thiazole have gained significant interest in the area of drug research and displayed broad range of biological activity such as anti-fungal, anti-bacterial, anti-inflammatory, anti-viral, anti-retroviral, anti-convulsant, anti-cancer, anti-neoplastics activities. So far modifications of substituted thiazole ring have proved highly effectiveness to improve potency and lesser toxicity. The literature survey shows that “The ultrasonic studies of very few thiazoles have been reported so far, hence it was thought to under taken such ultrasonic studies of some substituted thiazoles to obtain ultrasonic velocity data for ternary liquids mixtures. Since, acoustics parameter provides a better insight into molecular environment in liquid molecular interaction which motivates the author to carry out the present review. This review article highlights the recent accelerating rate of investigation in ultrasonic studies of some substituted thiazoles and covers the most active heterocyscles that have considerable important biological activities.


  1. Dua Rajiv., shrivastava Suman., Sonwane S.K. and Shrivastava S.K., Pharmacological significances of synthetic heterocyclic scaffold: A review, Advances in biological research, 5(3), 120-144 (2011)
  2. Geeta Mishra, Sing Arvind K. and Kshtiz Jyoti. R., 1, 3, 4-Thiadiazole derivatives and its pharmacological activity, Int. J. of chem. Tech. Research, 3(3), 1380-1390 (2011)
  3. Valverde, M G. and Torroba T., sulphur-nitrogen heterocycles, Molecules, 10, 318-320 (2005)
  4. Torroba T., Poly-sulphur-nitrogen heterocyclic via sulphur chloride and nitrogen reagent, J.Prakt.Chem.,341, 99-113 (1999)
  5. Young D.W., Heterocyclic chemistry, 1st ed. London: Long man group Ltd, (1975)
  6. Deosarkar S.D., Jahagirdar H.G. and Talwatkar V.B., Acoustical studies of some pyrazole in different percentage of Dioxane- water mixtures at 303, 15 K,. RASAYAN Journal. Chemistry, 3(4), 755-760 (2010)
  7. Campaigne E and Adrien Albert, Rationalization of heterocyclic chemistry, J. Chemical Education, 860(1986)
  8. Arora Pragi, Arora Varun , Lamba H.S. and Wadhwa Deepak., Importance of heterocyclic compounds: A Review, Int. Journal of Pharm. Science and Research., 3(9), 2947-2954 (2012)
  9. Gilchirst T.L, Heterocyclic chemistry, 3, 1 (1992)
  10. Foye W.O. and Thomos L., Foyes principles of medicinal chemistry, 6,754 (2007)
  11. Kunied T.K. and Mutsanga H., The chemistry of heterocyclic compounds, Palmer, 175, (2002)
  12. Eicher T and Hauptmann S., The chemistry of heterocyclic structure, Reaction, Synthesis and application, Wiley-VCH (2nd ed (2003)
  13. Bansal Raj K, Heterocyclic Chemistry, fourth ed, (1999)
  14. Chitamber C.R. and Wereley J.P., Journal of Bio. Chem., 272, 12151 (1997)
  15. Kant K., Singhal K., Shukla S.K., Chandrashekr K., Saxena A.K., Ranjan A. and Raj P., Phosphorus Sulfur and silicon, Bioactivity.,183, 2029 (2008)
  16. Gupta Vijayta. and Kant Vinay., A review on biological activity of imidazole and thiozole moieties and their derivatives, Science international 1(7), 253-260 (2013)
  17. Siddqui Nadeem., M.faiz, Arshad. W., Aquar Ahsan M. and Shamsher alam., Thiozole: A valuable insight into the recent advances and biological activities, Int. j. pharm. sci. drug. Res.,1(3), 136-143 (2009)
  18. Mehar Chaitanya prsad, A current Review on thiozole nucles and its derivatives, Pharma tutorPHARMA Tutor Art , 1(5),1931 (2013)
  19. Kashyap S.J., Sharma P.K., Garg V.K, Dudhe R and N Kumar., Review on synthesis and various biological potential of thiazole pyramidine derivative, Journal of. Adv. Sci. Res., 2, 18-24 (2011)
  20. Bishoyee A., Karmakler R.S., Kundu S.N. and Chatrjee M.,Vanadiam-mediatchemoprotection against chemical hepatocarcinogenesis in rats: haematolgical and histological characteristics, Euro J. Cancer Prev, 6, 58-70 (1997)
  21. Cruz T.F., Morgon A. and Min W., Synthesis and biological evaluation of some substituted amino-thiazole derivatives, Mol. Biochem.,153, 161 (1995)
  22. Hargrave K.D., Hess F.K. and Oliver J.T., N-(4-substituted thiazolyl) oxamic acidderivatives, new series of potent orally active anti-allergy agents, J. Medidicinal Chemistry, 26, 1158-1163 (1983)
  23. Patt W.C., Hamilton H.W., Taylor M.D., Ryan M.J. And Taylor D.G Jr., Structure- activity relationships of series of 2-Amino-4-Thiazole containing renin inhibitors, Journal of Medicinal Chemistry, 35(14),2562-2572 (1992)
  24. Sharma R.N., Xavier F.P., Vasu K.K., Chaturvedi S.C. and Pancholi S.S., Synthesis of 4- benzyl-1, 3-thiazole derivatives as potential anti-inflammatory agents: An analogue-based drug design approach. Journal Enzyme Inhibition Med. Chem.,24(3), 890-897(2009)
  25. Jean J.C., Wise L.D., Caprathe B.W., Tecle H and Bergmeier S., 4-(1,2,5,6-Tetrahydro-1-alkyl-3pyridinyl)-thiazolamines: A novel class of compounds with central dopamine agonist properties, J. Med. Chem., 33, 311-317 (1990)
  26. Bhattacharya P., Leonard J.T. and Roy K., Exploring QSAR of thiazole and thiadiazole derivatives as potent and selective human adenosis-A receptor antagonists using FA and GFA techniques, Bioorganic and medicinal chemistry,13(4), 1159-1165 (2005)
  27. Ergenc N.G., Capan N.S., Gunay S., Ozkirimli Gungor M., Ozbey S. and Kendi E., Synthesis and hypnotic activity of new 4-thiazolidinone and 2- thiaxo-4,5-imadizolidinedione derivatives, Arch. Pharm. Pharm. Med. Chem., 332, 343-347(1999)
  28. Cartner J.S., Kramer S., Talley J.J., Penning T and Collins P., Synthesis and activity of sulfonamide-substituted 4, 5-diaryl thiazoles as selective cyclo oxygenase-2 inhibitors, Bioorg. Med.Chem. Lett.,, 1171-1174 (1999)
  29. Badore A., Bordes M.F., de Cointet P., Savi P. and Bernat A. et. al., New orally active non-peptide fibrinogen receptor (GpIIb-IIIa) antagonists: Idenfictionofethy l3-(N-(4-(-Amino (ethoxycarbonyl)imino)methyl)phenyl)-1,3 thiazole-2-yl)-N-(1-ethoxycarbonyl) methyl)piperid-4-yl amino) propionate (SR121787) as potent and long acting antithrombotic agent, Journal of Med. Chemistry, 40, 3393-3401 (1997)
  30. Rudolph J., Theis H., Hanke R., Endermann R., Johannsen L. and Geschke F.U., Seco-cyclothialidines : New Concise synthesis. Inhibitory activity toward bacterial and human DNA topo-isomerases and anti-bacterial properties, J. Med. Chem.,44, 619-626 (2001)
  31. Rogers M.J., Cundliffe E. and Mccutchan T.F., Synthesis and biological evaluation of some substituted amino thiazole, Antimicrobial agents and chemotherapy, 42(3),715-716, (1966)
  32. Partan S.R., Dighe N.S., Nirmal S.A., Merekar A.N., Laware R.B., Shinde H.V. and Musmade D.S., Synthesis and biological evaluation of some substituted aminothiazole, Asian J. Research Chem., 2(2), 196 (2009)
  33. Argyropoulou I., Geronikaki A., Vicini P. and Zanib F, Synthesis and biological evaluation of sulphonamide thiazole and benzothiazole derivatives as antimicrobial agent, Arkivoc. VI, 89, 102S, (2009)
  34. Trautman H.D. and Longe L.M., The synthesis of 2, 3disubstituted-4-thiazolidones, J. Am. Chem. Soc.,70(10), 3436-3439 (1948)
  35. Surray A.R., 4-Thiazolidones.iv.The preparation of some 3-alkylaminoalkyl-2-aryl derivatives, J. Am. Chem. Soc., 71, 3354-56 (1949)
  36. Karade H.N., B.N Acharya B.N., Sathe M. and Kaushik M.P., Design, Synthesis and anti-malarial evaluation of thiazole-derived amino acids, Medicinal Chemistry Research, 17, 19-29 (2008)
  37. Narayana B., Vijaya Raj K K, Ashalata B.V., Kumari N.S. and Sarojini BK, Synthesis of some new 5-(2-substituted1, -3-thiazole -5-yl) -2-hydroxy benzamides and their 2-alkoxy derivatives as possible antifungal agents, Eur. J. Med. Chem., 39, 867-872 (2004)
  38. Mostafa M.S. and Abd N.M., EL-Salam, Synthesis and biological evaluation of 3-methyl –pyrazolin-5-one derivatives containing thiazole and indole moieties, Der. Pharma. Chemica.,5, 1-7 (2013)
  39. Clark RF, Zhang T, Wang X, Wang R, Zhang X, Camp HS, Beutel BA, Sham HL and Gu YJ., Phenoxy thiazole derivatives as potent and selective acetyl Co-A carboxylase-2 inhibitors: Modulation of isozyme selectivity by incorporation of phenyl ring substituent, Bioorg Med. Chem. Lett, 17, 1961-1965 (2007)
  40. Andreani A., Rambaldi M,,Mascellani G. and Rugarli P., Synthesis and diuretic activity of imidazol[2,1-b] thiazole acetohydrazones, Eur. J.Med. Chem.,22, 19-22 (1987)
  41. Koufaki M, Kiziridi C, Nikoludaki F and Alexis M.N., Design and synthesis of 1-2- dithiolane derivatives and evaluation of their neuroprotective activity, Bioorg. Med. Chem .Lett.,17, 4223-4227 (2007)
  42. Kannapan V., Xavier Jesu Raja and Jaya shanthi R.,Ultrasonics studies on molecular interaction of certain carbonyl compounds in n-hexane and chloroform solution, Ind, J, pure Appl. Phys.,41, 690 (2003)
  43. 3.Voleisiene B. and Voleisis A., Ultrasonic velocity measurement in liquid media Ultra Garsas(Ultrasound).,63(4), 9-10 (2008)
  44. Sunsilk K.S., homogeneous sonocheistry in ultrasound its chemical physical and biological effect VCH publishers Inc, New York 123-163, (1988)
  45. Mason T.J., An introduction to sonochemistry http; users. /-mason dr/sonochemistry, (2003)
  46. Kaatze V. et al, Ultrasonic velocity measurement in liquids with high resolution techniques selected application and perspectives, Means Science Technol.,/ EJ/., 19(6), 21 (2001)
  47. Sri Laxmi R.M., Ramesh R. Raju., Rambabu C., Ramarao G.V. and Narendra K., Study of molecular interaction in binary liquid mixtures containing higher alcohols at different temperatures, Res. and Rev. J. Chem., 2(1), 12-24 (2013)
  48. Shvekhgeimer G.A., Review: Use of ultrasound in heterocyclic chemistry, Chemistry of heterocyclic compounds, 30(6), 633-660 (1994)
  49. Rodrigo Cella and Hello A Stefani, Ultrasound in heterocyclic chemistry: Review article, Tetrahedron. 65(13), 2619-2641 (2009)
  50. Javad Safaei Ghomi and Mohammad Ali Ghasemzadeh, Ultrasound-assisted synthesis of dihydropyrimidine-2-thiones., Journal. Serb. Chem. Soc. 76(5), 679-684 (2011)
  51. Vibhu. I., Mishra A., Gupta M. and Shukla J.D., Ultrasonic and infrared Studies of molecular interaction in ternary mixtures of 1 and 2 naphthanol with 2-propane in benzene, Ind. J. Physics.,5, 1147-1105 (2004)
  52. Thoe T.B. and Aspinwall D.K., Wise MLH. Review on Ultrasonic machining, Int. J. mach Tools manufact.,38, 239-55 (1998)
  53. Gareth Thomos, Chemistry for pharmacy and the life sciences, Prentics Hall, London, Chapter-2, 15 and 24, (1996)
  54. Anas M., Ababneh Large C.C. and Georghiou S., Solvation of nucleosides in aqueous mixtures of organic solvents: Relevance to DNA open base pair., Bio phys. ournal, 85(2), 1111-1127 (2003)
  55. Robert E. Treybal mass transfer operations 3rded Singapore McGraw hill co; section (1981)
  56. Mason T.J., Lorimar J.P., Ultrasonic in sonochemistry; theory, application and uses of ultrasound in chemistry, Ellis Hordwoods publishers, chichester, 1-16 (1998)
  57. Gulwade Deepali P., Narwade M.N. and Wadodkar K.N., Ultrasonic behavior and study of molecular interaction of substituted azole in N,N -dimethyl formamide at different temperature, Ind. J. of Chemistry, (43A), 2012-2014 (2004)
  58. Talegaonkar R., Burghate A.S. and Wadal S.A., Studies of some acoustic properties of substituted thiazole Schiff’s bases in binary solvent mixtures at 30 ± 0.c RASAYAN J. Chemistry, 6(10), 7-11, (2013)
  59. Ikhe S.A. and Narwade M.L., Ultrasonic studies of substituted isothaizole and pyrazole in dioxane and dioxane water mixtures at different temperature, Indian J. of Chemistry,44(A), 1203-1205 (2005)
  60. Aly ashraf A., Ishak Esanm A., Moneim Amin Abd El, Alenezy Mohammed D.N.S. Abd El Aql and L. Abd El Latif, Ultrasonic studies on molecular interaction of substituted thiazoledines in acetone using pulse-echo techniques, J. Chemical and pharmaceutical Researc,5(11), 762-767 (2013)
  61. Baluja S., Talavaiya R. and Bhesaniya K., Acoustical studies of some benzo (d) thiazole deriviates in 1-4 Dioxane and N-N Dimethyl formamide at 303.50 K, J. Chem Bio. Phy. Sci. Sec. A, 3(4), 2438-2445 (2013)
  62. Vadamalar R., Mani D. and Balakrishnan R., Ultrasonic study of binary liquid mixtures of methyl methacrylatewith alcohols, Research Journal of chemical sciences,1(9), 79-82 (2011)
  63. Nath G., Sahu S and Paikaray R., studies on thermo acoustical parameters in binary liquid mixtures of MIBK with 1-propanol,1-butanol and 1-pentanol at303.15K, Research journal of chemical sciences,1(5), 6-13 (2011)