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Ligand based Pharmacophore Modeling of some Angiotensin II Receptor Antagonist

Author Affiliations

  • 1Shri G.S. Institute of Technology and Science, 23 Park Road, Indore, INDIA

Res.J.chem.sci., Volume 5, Issue (3), Pages 57-62, March,18 (2015)

Abstract

Angiotensin receptor blockers (ARBs) are group of Antihypertensive drugs that act by blocking the effect of harmone Angiotensin II in the body there by lowering blood pressure. The discovery and development of ARBs is a demonstrative example of modern rational drug design. Major goal of modern drug design is identification and development of new ligands with high affinity of binding towards a given protein receptor .A very useful model for achieving this goal is pharmacophore . In the presented work, a 3 D pharmacophore has been developed in order to assist the discovery of some novel and potent angiotensin II receptor antagonist.Ligand based pharmacophore modelling has been done here, which is playing a key role for the identification of ligand features for the particular targets. Ligand Scout 3.00 has been used to predict the pharmacophoric features for Angiotensin II receptor antagonist. Result indicates that the in silico methods are useful in predicting the biological activity of the compound or compound library by screening it against a predicted pharmacophore.

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